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Items: 1 to 20 of 99

1.

Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease.

Huang N, Erie C, Lu ML, Wei J.

Mol Cell Neurosci. 2018 Apr;88:43-52. doi: 10.1016/j.mcn.2017.12.005. Epub 2017 Dec 12.

PMID:
29246658
2.

Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.

Lim J, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z.

PLoS Genet. 2015 Feb 27;11(2):e1004987. doi: 10.1371/journal.pgen.1004987. eCollection 2015.

3.

ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.

Lee H, Ahn HH, Lee W, Oh Y, Choi H, Shim SM, Shin J, Jung YK.

Mol Neurobiol. 2016 Dec;53(10):6620-6634. Epub 2015 Dec 5.

PMID:
26637326
4.

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.

Wold MS, Lim J, Lachance V, Deng Z, Yue Z.

Mol Neurodegener. 2016 Dec 9;11(1):76.

5.

Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

Myeku N, Figueiredo-Pereira ME.

J Biol Chem. 2011 Jun 24;286(25):22426-40. doi: 10.1074/jbc.M110.149252. Epub 2011 May 2.

6.

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14. Epub 2005 Nov 14.

7.

Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts.

Kato M, Ospelt C, Gay RE, Gay S, Klein K.

Arthritis Rheumatol. 2014 Jan;66(1):40-8. doi: 10.1002/art.38190.

8.

p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress.

Su H, Wang X.

Trends Cardiovasc Med. 2011 Nov;21(8):224-8. doi: 10.1016/j.tcm.2012.05.015. Review.

9.

Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite.

Lee H, Kim MN, Ryu KY.

Biochem Biophys Res Commun. 2017 May 6;486(3):839-844. doi: 10.1016/j.bbrc.2017.03.146. Epub 2017 Mar 28.

PMID:
28359760
10.

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.

Hum Mol Genet. 2012 Jan 1;21(1):101-14. doi: 10.1093/hmg/ddr445. Epub 2011 Sep 27.

PMID:
21954231
11.

SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.

Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW, Wooten MC.

PLoS One. 2013 Sep 27;8(9):e76016. doi: 10.1371/journal.pone.0076016. eCollection 2013.

12.

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K.

PLoS One. 2013 Jul 29;8(7):e69563. doi: 10.1371/journal.pone.0069563. Print 2013.

13.

Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62.

Nakashima H, Nguyen T, Goins WF, Chiocca EA.

J Biol Chem. 2015 Jan 16;290(3):1485-95. doi: 10.1074/jbc.M114.593871. Epub 2014 Nov 26.

14.

Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases.

Kurosawa M, Matsumoto G, Sumikura H, Hatsuta H, Murayama S, Sakurai T, Shimogori T, Hattori N, Nukina N.

Neurosci Res. 2016 Feb;103:64-70. doi: 10.1016/j.neures.2015.08.002. Epub 2015 Aug 21.

PMID:
26302676
15.

Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.

Xu Y, Zhang J, Tian C, Ren K, Yan YE, Wang K, Wang H, Chen C, Wang J, Shi Q, Dong XP.

Med Microbiol Immunol. 2014 Apr;203(2):73-84. doi: 10.1007/s00430-013-0316-z. Epub 2013 Nov 17.

PMID:
24240628
16.

SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity.

Demishtein A, Fraiberg M, Berko D, Tirosh B, Elazar Z, Navon A.

Autophagy. 2017 Oct 3;13(10):1697-1708. doi: 10.1080/15548627.2017.1356549. Epub 2017 Aug 9.

17.

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.

Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.

Hum Mol Genet. 2015 Feb 15;24(4):1092-105. doi: 10.1093/hmg/ddu522. Epub 2014 Oct 9.

PMID:
25305080
18.

Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease.

Erie C, Sacino M, Houle L, Lu ML, Wei J.

Eur J Neurosci. 2015 Aug;42(3):1941-51. doi: 10.1111/ejn.12957. Epub 2015 Jun 19.

19.

Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

Pankiv S, Lamark T, Bruun JA, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2010 Feb 19;285(8):5941-53. doi: 10.1074/jbc.M109.039925. Epub 2009 Dec 15.

20.

p62/SQSTM1 is involved in caspase-8 associated cell death induced by proteasome inhibitor MG132 in U87MG cells.

Zeng RX, Zhang YB, Fan Y, Wu GL.

Cell Biol Int. 2014 Oct;38(10):1221-6. doi: 10.1002/cbin.10311. Epub 2014 May 19.

PMID:
24805111

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