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Items: 1 to 20 of 113


Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model.

Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M.

J Biol Chem. 2017 Nov 24;292(47):19458-19468. doi: 10.1074/jbc.M117.808105. Epub 2017 Oct 2.


Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M.

Endocrinology. 2009 Aug;150(8):3465-74. doi: 10.1210/en.2008-1557. Epub 2009 Apr 30.


Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.

Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Madiraju SRM, Prentki M.

J Biol Chem. 2017 May 5;292(18):7407-7422. doi: 10.1074/jbc.M116.763060. Epub 2017 Mar 9.


A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.

Guay C, Joly E, Pepin E, Barbeau A, Hentsch L, Pineda M, Madiraju SR, Brunengraber H, Prentki M.

PLoS One. 2013 Oct 10;8(10):e77097. doi: 10.1371/journal.pone.0077097. eCollection 2013.


Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.

ElAzzouny MA, Evans CR, Burant CF, Kennedy RT.

PLoS One. 2015 Jun 24;10(6):e0129029. doi: 10.1371/journal.pone.0129029. eCollection 2015.


A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.

Guay C, Madiraju SR, Aumais A, Joly E, Prentki M.

J Biol Chem. 2007 Dec 7;282(49):35657-65. Epub 2007 Oct 10.


Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.

Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB.

J Biol Chem. 2002 Apr 5;277(14):11746-55. Epub 2002 Jan 30.


A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells.

De Marchi U, Hermant A, Thevenet J, Ratinaud Y, Santo-Domingo J, Barron D, Wiederkehr A.

J Cell Sci. 2017 Jun 1;130(11):1929-1939. doi: 10.1242/jcs.200741. Epub 2017 Apr 12.


Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.

Düfer M, Noack K, Krippeit-Drews P, Drews G.

Islets. 2010 May-Jun;2(3):156-63. doi: 10.4161/isl.2.3.11412.


Metabolome response to glucose in the β-cell line INS-1 832/13.

Lorenz MA, El Azzouny MA, Kennedy RT, Burant CF.

J Biol Chem. 2013 Apr 12;288(15):10923-35. doi: 10.1074/jbc.M112.414961. Epub 2013 Feb 20.


Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell.

MacDonald MJ, Smith AD 3rd, Hasan NM, Sabat G, Fahien LA.

J Biol Chem. 2007 Oct 19;282(42):30596-606. Epub 2007 Aug 27.


Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion.

Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe M, Oiso Y, Takenawa T, Seino S.

J Biol Chem. 2013 Sep 6;288(36):25851-64. doi: 10.1074/jbc.M113.464420. Epub 2013 Jul 18.


Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation.

Panten U, Willenborg M, Schumacher K, Hamada A, Ghaly H, Rustenbeck I.

Metabolism. 2013 Oct;62(10):1375-86. doi: 10.1016/j.metabol.2013.05.006. Epub 2013 Jun 18.


Mathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell line.

Salvucci M, Neufeld Z, Newsholme P.

PLoS One. 2013;8(3):e52611. doi: 10.1371/journal.pone.0052611. Epub 2013 Mar 8.


Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio.

Masini M, Anello M, Bugliani M, Marselli L, Filipponi F, Boggi U, Purrello F, Occhipinti M, Martino L, Marchetti P, De Tata V.

Diabetes Res Clin Pract. 2014 Apr;104(1):163-70. doi: 10.1016/j.diabres.2013.12.031. Epub 2014 Jan 3.


Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, Geibel JP, Fuerst J, Ritter M.

Cell Physiol Biochem. 2012;29(1-2):75-86. doi: 10.1159/000337589. Epub 2012 Mar 1.


Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

Malmgren S, Nicholls DG, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H, Sharoyko VV.

J Biol Chem. 2009 Nov 20;284(47):32395-404. doi: 10.1074/jbc.M109.026708. Epub 2009 Sep 21.


A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M.

Diabetes. 2004 Apr;53(4):1007-19.

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