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Items: 1 to 20 of 103

1.

Bridging Microscopic and Macroscopic Mechanisms of p53-MDM2 Binding with Kinetic Network Models.

Zhou G, Pantelopulos GA, Mukherjee S, Voelz VA.

Biophys J. 2017 Aug 22;113(4):785-793. doi: 10.1016/j.bpj.2017.07.009.

2.

Binding induced folding in p53-MDM2 complex.

Chen HF, Luo R.

J Am Chem Soc. 2007 Mar 14;129(10):2930-7. Epub 2007 Feb 16.

3.

Structural details on mdm2-p53 interaction.

Chi SW, Lee SH, Kim DH, Ahn MJ, Kim JS, Woo JY, Torizawa T, Kainosho M, Han KH.

J Biol Chem. 2005 Nov 18;280(46):38795-802. Epub 2005 Sep 13.

4.
5.

Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction.

Ciemny MP, Debinski A, Paczkowska M, Kolinski A, Kurcinski M, Kmiecik S.

Sci Rep. 2016 Dec 1;6:37532. doi: 10.1038/srep37532.

6.

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4665-70. doi: 10.1073/pnas.0900947106. Epub 2009 Mar 2.

7.

Efficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.

Zwier MC, Pratt AJ, Adelman JL, Kaus JW, Zuckerman DM, Chong LT.

J Phys Chem Lett. 2016 Sep 1;7(17):3440-5. doi: 10.1021/acs.jpclett.6b01502. Epub 2016 Aug 22.

8.

Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.

Lee HJ, Srinivasan D, Coomber D, Lane DP, Verma CS.

Cell Cycle. 2007 Nov 1;6(21):2604-11. Epub 2007 Aug 20.

PMID:
17957142
9.

The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans.

Zhan YA, Ytreberg FM.

Arch Biochem Biophys. 2015 Jun 1;575:22-9. doi: 10.1016/j.abb.2015.03.021. Epub 2015 Apr 1.

10.

Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.

Pantelopulos GA, Mukherjee S, Voelz VA.

Proteins. 2015 Sep;83(9):1665-76. doi: 10.1002/prot.24852. Epub 2015 Jul 21.

PMID:
26138282
11.

Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations.

Xiong K, Zwier MC, Myshakina NS, Burger VM, Asher SA, Chong LT.

J Phys Chem A. 2011 Sep 1;115(34):9520-7. doi: 10.1021/jp112235d. Epub 2011 Apr 29.

12.

Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53.

Lum JK, Neuweiler H, Fersht AR.

J Am Chem Soc. 2012 Jan 25;134(3):1617-22. doi: 10.1021/ja2078619. Epub 2012 Jan 12.

13.

Conformational changes of the p53-binding cleft of MDM2 revealed by molecular dynamics simulations.

Espinoza-Fonseca LM, Trujillo-Ferrara JG.

Biopolymers. 2006 Nov;83(4):365-73.

PMID:
16817233
14.

Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition.

Shin JS, Ha JH, Lee DH, Ryu KS, Bae KH, Park BC, Park SG, Yi GS, Chi SW.

Cell Cycle. 2015;14(4):533-43. doi: 10.1080/15384101.2014.998056.

15.

Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.

Zhan YA, Wu H, Powell AT, Daughdrill GW, Ytreberg FM.

Proteins. 2013 Oct;81(10):1738-47. doi: 10.1002/prot.24310. Epub 2013 Jul 22.

16.

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.

Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP.

Science. 1996 Nov 8;274(5289):948-53.

PMID:
8875929
17.

A computational analysis of binding modes and conformation changes of MDM2 induced by p53 and inhibitor bindings.

Chen J, Wang J, Zhu W, Li G.

J Comput Aided Mol Des. 2013 Nov;27(11):965-74. doi: 10.1007/s10822-013-9693-z. Epub 2013 Nov 22.

PMID:
24264557
18.

Dual-site regulation of MDM2 E3-ubiquitin ligase activity.

Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL.

Mol Cell. 2006 Jul 21;23(2):251-63.

19.

Design of a novel MDM2 binding peptide based on the p53 family.

Madhumalar A, Lee HJ, Brown CJ, Lane D, Verma C.

Cell Cycle. 2009 Sep 1;8(17):2828-36. Epub 2009 Sep 14.

PMID:
19713735
20.

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