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Items: 1 to 20 of 101


Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.

Jesse S, Bayer H, Alupei MC, Zügel M, Mulaw M, Tuorto F, Malmsheimer S, Singh K, Steinacker J, Schumann U, Ludolph AC, Scharffetter-Kochanek K, Witting A, Weydt P, Iben S.

Sci Rep. 2017 Aug 17;7(1):8513. doi: 10.1038/s41598-017-09148-7.


Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner.

Erlich AT, Brownlee DM, Beyfuss K, Hood DA.

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C62-C72. doi: 10.1152/ajpcell.00162.2017. Epub 2017 Oct 18.


Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes.

Yan Y, Yang X, Zhao T, Zou Y, Li R, Xu Y.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):436-441. doi: 10.1016/j.bbrc.2017.07.074. Epub 2017 Jul 13.


Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway.

Jiang S, Teague AM, Tryggestad JB, Chernausek SD.

Biochem Biophys Res Commun. 2017 Jun 3;487(3):607-612. doi: 10.1016/j.bbrc.2017.04.099. Epub 2017 Apr 19.


Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D.

Cell. 2006 Oct 6;127(1):59-69.


Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.

Martin E, Betuing S, Pagès C, Cambon K, Auregan G, Deglon N, Roze E, Caboche J.

Hum Mol Genet. 2011 Jun 15;20(12):2422-34. doi: 10.1093/hmg/ddr148. Epub 2011 Apr 14.


PGC-1α, mitochondrial dysfunction, and Huntington's disease.

Johri A, Chandra A, Flint Beal M.

Free Radic Biol Med. 2013 Sep;62:37-46. doi: 10.1016/j.freeradbiomed.2013.04.016. Epub 2013 Apr 19. Review.


Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y.

PLoS One. 2010 Jul 22;5(7):e11707. doi: 10.1371/journal.pone.0011707.


Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.

Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.


An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes.

Chang JS, Ha K.

J Biol Chem. 2017 Jun 16;292(24):9958-9966. doi: 10.1074/jbc.M117.778373. Epub 2017 May 4.


PGC-1α-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration.

Ma L, Niu W, Lv J, Jia J, Zhu M, Yang S.

Cell Mol Neurobiol. 2018 Nov;38(8):1529-1537. doi: 10.1007/s10571-018-0628-z. Epub 2018 Oct 12.


Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. Epub 2006 Sep 15.


Stimulatory effect of CSE-generated H2S on hepatic mitochondrial biogenesis and the underlying mechanisms.

Untereiner AA, Fu M, Módis K, Wang R, Ju Y, Wu L.

Nitric Oxide. 2016 Aug 31;58:67-76. doi: 10.1016/j.niox.2016.06.005. Epub 2016 Jun 27.


Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease.

Chen LW, Horng LY, Wu CL, Sung HC, Wu RT.

Neuropharmacology. 2012 Sep;63(4):719-32. doi: 10.1016/j.neuropharm.2012.05.019. Epub 2012 May 24.


PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR.

Sci Transl Med. 2012 Jul 11;4(142):142ra97. doi: 10.1126/scitranslmed.3003799.


MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis.

Koh E, Kim YK, Shin D, Kim KS.

Biochem J. 2018 May 18;475(10):1687-1699. doi: 10.1042/BCJ20170967.


Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.

Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X.

J Neurochem. 2012 Feb;120(3):419-29. doi: 10.1111/j.1471-4159.2011.07581.x. Epub 2011 Dec 8.


Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway.

Zhang CL, Feng H, Li L, Wang JY, Wu D, Hao YT, Wang Z, Zhang Y, Wu LL.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3085-3094. doi: 10.1016/j.bbagen.2016.10.022. Epub 2016 Oct 26.


Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/ NRF1/TFAM signaling pathway.

Chen Z, Tao S, Li X, Yao Q.

Biochem Biophys Res Commun. 2018 Sep 26;504(1):13-18. doi: 10.1016/j.bbrc.2018.08.027. Epub 2018 Aug 29.


Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

Safdar A, Little JP, Stokl AJ, Hettinga BP, Akhtar M, Tarnopolsky MA.

J Biol Chem. 2011 Mar 25;286(12):10605-17. doi: 10.1074/jbc.M110.211466. Epub 2011 Jan 18.

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