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Items: 1 to 20 of 95

1.

Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.

Angel PM, Narmoneva DA, Sewell-Loftin MK, Munjal C, Dupuis L, Landis BJ, Jegga A, Kern CB, Merryman WD, Baldwin HS, Bressan GM, Hinton RB.

Ann Biomed Eng. 2017 Nov;45(11):2548-2562. doi: 10.1007/s10439-017-1899-0. Epub 2017 Aug 15.

2.

TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.

Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB.

Dis Model Mech. 2014 Aug;7(8):987-96. doi: 10.1242/dmm.015255.

3.

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.

Munjal C, Jegga AG, Opoka AM, Stoilov I, Norris RA, Thomas CJ, Smith JM, Mecham RP, Bressan GM, Hinton RB.

Physiol Rep. 2017 Mar;5(5). pii: e13152. doi: 10.14814/phy2.13152.

4.

Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease.

Krishnamurthy VK, Opoka AM, Kern CB, Guilak F, Narmoneva DA, Hinton RB.

Matrix Biol. 2012 Apr;31(3):197-205. doi: 10.1016/j.matbio.2012.01.001. Epub 2012 Jan 12.

5.

Regional structure-function relationships in mouse aortic valve tissue.

Krishnamurthy VK, Guilak F, Narmoneva DA, Hinton RB.

J Biomech. 2011 Jan 4;44(1):77-83. doi: 10.1016/j.jbiomech.2010.08.026. Epub 2010 Sep 21.

6.

Dysregulation of hyaluronan homeostasis during aortic valve disease.

Krishnamurthy VK, Stout AJ, Sapp MC, Matuska B, Lauer ME, Grande-Allen KJ.

Matrix Biol. 2017 Oct;62:40-57. doi: 10.1016/j.matbio.2016.11.003. Epub 2016 Nov 15.

PMID:
27856308
7.

Elastin microfibril interface-located protein 1, transforming growth factor beta, and implications on cardiovascular complications.

Randell A, Daneshtalab N.

J Am Soc Hypertens. 2017 Jul;11(7):437-448. doi: 10.1016/j.jash.2017.04.010. Epub 2017 May 3. Review.

PMID:
28545768
8.

Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells.

Fang M, Alfieri CM, Hulin A, Conway SJ, Yutzey KE.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2601-8. doi: 10.1161/ATVBAHA.114.304579. Epub 2014 Oct 23.

9.

Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model.

Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Osinska H, Sakthivel B, James JF, Li DY, Narmoneva DA, Mecham RP, Benson DW.

Circ Res. 2010 Aug 20;107(4):549-57. doi: 10.1161/CIRCRESAHA.110.221358. Epub 2010 Jun 24.

10.

Progressive aortic valve calcification: three-dimensional visualization and biomechanical analysis.

Halevi R, Hamdan A, Marom G, Mega M, Raanani E, Haj-Ali R.

J Biomech. 2015 Feb 5;48(3):489-97. doi: 10.1016/j.jbiomech.2014.12.004. Epub 2014 Dec 18.

PMID:
25553668
11.

TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves.

Hagler MA, Hadley TM, Zhang H, Mehra K, Roos CM, Schaff HV, Suri RM, Miller JD.

Cardiovasc Res. 2013 Jul 1;99(1):175-84. doi: 10.1093/cvr/cvt083. Epub 2013 Apr 3.

12.

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.

Dupuis LE, Osinska H, Weinstein MB, Hinton RB, Kern CB.

J Mol Cell Cardiol. 2013 Jul;60:50-9. doi: 10.1016/j.yjmcc.2013.03.010. Epub 2013 Mar 24.

13.

Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase.

El Accaoui RN, Gould ST, Hajj GP, Chu Y, Davis MK, Kraft DC, Lund DD, Brooks RM, Doshi H, Zimmerman KA, Kutschke W, Anseth KS, Heistad DD, Weiss RM.

Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1302-13. doi: 10.1152/ajpheart.00392.2013. Epub 2014 Mar 7.

14.

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.

Huk DJ, Austin BF, Horne TE, Hinton RB, Ray WC, Heistad DD, Lincoln J.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):328-38. doi: 10.1161/ATVBAHA.115.306091. Epub 2015 Dec 3.

15.

Noticeable decreased expression of tenascin-X in calcific aortic valves.

Matsumoto K, Satoh K, Maniwa T, Araki A, Maruyama R, Oda T.

Connect Tissue Res. 2012;53(6):460-8. doi: 10.3109/03008207.2012.702818. Epub 2012 Jul 24.

PMID:
22827484
16.

Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-κB and ERK1/2 pathways.

Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X.

Int J Biol Sci. 2015 Mar 20;11(4):482-93. doi: 10.7150/ijbs.10905. eCollection 2015.

17.

β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells.

Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):590-7. doi: 10.1161/ATVBAHA.110.220061. Epub 2010 Dec 2.

PMID:
21127288
18.

Inhibitory role of Notch1 in calcific aortic valve disease.

Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, Garg V.

PLoS One. 2011;6(11):e27743. doi: 10.1371/journal.pone.0027743. Epub 2011 Nov 16.

19.

Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves.

Angel PM, Nusinow D, Brown CB, Violette K, Barnett JV, Zhang B, Baldwin HS, Caprioli RM.

J Proteome Res. 2011 Feb 4;10(2):812-23. doi: 10.1021/pr1009806. Epub 2010 Dec 22.

20.

Functional collagen fiber architecture of the pulmonary heart valve cusp.

Joyce EM, Liao J, Schoen FJ, Mayer JE Jr, Sacks MS.

Ann Thorac Surg. 2009 Apr;87(4):1240-9. doi: 10.1016/j.athoracsur.2008.12.049.

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