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Items: 1 to 20 of 137

1.

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.

Fazio EN, Young CC, Toma J, Levy M, Berger KR, Johnson CL, Mehmood R, Swan P, Chu A, Cregan SP, Dilworth FJ, Howlett CJ, Pin CL.

Mol Biol Cell. 2017 Sep 1;28(18):2347-2359. doi: 10.1091/mbc.E17-04-0254. Epub 2017 Jul 12.

2.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

3.

Epigenetic reprogramming in Mist1(-/-) mice predicts the molecular response to cerulein-induced pancreatitis.

Mehmood R, Varga G, Mohanty SQ, Laing SW, Lu Y, Johnson CL, Kharitonenkov A, Pin CL.

PLoS One. 2014 Jan 21;9(1):e84182. doi: 10.1371/journal.pone.0084182. eCollection 2014.

4.

Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer.

Wauters E, Sanchez-Arévalo Lobo VJ, Pinho AV, Mawson A, Herranz D, Wu J, Cowley MJ, Colvin EK, Njicop EN, Sutherland RL, Liu T, Serrano M, Bouwens L, Real FX, Biankin AV, Rooman I.

Cancer Res. 2013 Apr 1;73(7):2357-67. doi: 10.1158/0008-5472.CAN-12-3359. Epub 2013 Jan 31.

5.

Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6.

Prévot PP, Augereau C, Simion A, Van den Steen G, Dauguet N, Lemaigre FP, Jacquemin P.

Gastroenterology. 2013 Sep;145(3):668-78.e3. doi: 10.1053/j.gastro.2013.05.016. Epub 2013 May 16.

PMID:
23684747
6.

Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.

Cendrowski J, Lobo VJ, Sendler M, Salas A, Kühn JP, Molero X, Fukunaga R, Mayerle J, Lerch MM, Real FX.

Gut. 2015 Jun;64(6):937-47. doi: 10.1136/gutjnl-2013-306068. Epub 2014 Jul 18.

PMID:
25037190
7.

Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.

Grabliauskaite K, Saponara E, Reding T, Bombardo M, Seleznik GM, Malagola E, Zabel A, Faso C, Sonda S, Graf R.

J Pathol. 2016 Feb;238(3):434-45. doi: 10.1002/path.4666. Epub 2015 Nov 28.

PMID:
26510396
8.

p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.

Grabliauskaite K, Hehl AB, Seleznik GM, Saponara E, Schlesinger K, Zuellig RA, Dittmann A, Bain M, Reding T, Sonda S, Graf R.

J Pathol. 2015 Feb;235(3):502-14. doi: 10.1002/path.4440. Epub 2014 Nov 6.

9.

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model.

Hidalgo-Sastre A, Brodylo RL, Lubeseder-Martellato C, Sipos B, Steiger K, Lee M, von Figura G, Grünwald B, Zhong S, Trajkovic-Arsic M, Neff F, Schmid RM, Siveke JT.

Am J Pathol. 2016 Nov;186(11):2934-2944. doi: 10.1016/j.ajpath.2016.07.025. Epub 2016 Sep 14.

PMID:
27639167
10.

Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1.

Johnson CL, Mehmood R, Laing SW, Stepniak CV, Kharitonenkov A, Pin CL.

Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E916-28. doi: 10.1152/ajpendo.00559.2013. Epub 2014 Feb 18.

11.

Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis.

Kowalik AS, Johnson CL, Chadi SA, Weston JY, Fazio EN, Pin CL.

Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1123-32. Epub 2006 Dec 14.

12.

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD.

J Pathol. 2017 Sep;243(1):65-77. doi: 10.1002/path.4928. Epub 2017 Jul 27.

13.

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I.

J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.

PMID:
19585519
14.

Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.

Johnson CL, Peat JM, Volante SN, Wang R, McLean CA, Pin CL.

J Pathol. 2012 Nov;228(3):351-65. doi: 10.1002/path.4015. Epub 2012 May 2.

PMID:
22374815
15.

Snail1 is required for the maintenance of the pancreatic acinar phenotype.

Loubat-Casanovas J, Peña R, Gonzàlez N, Alba-Castellón L, Rosell S, Francí C, Navarro P, García de Herreros A.

Oncotarget. 2016 Jan 26;7(4):4468-82. doi: 10.18632/oncotarget.6785.

16.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

17.

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.

Gruber R, Panayiotou R, Nye E, Spencer-Dene B, Stamp G, Behrens A.

Gastroenterology. 2016 Sep;151(3):526-39. doi: 10.1053/j.gastro.2016.05.006. Epub 2016 May 20.

18.

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Martinelli P, Madriles F, Cañamero M, Pau EC, Pozo ND, Guerra C, Real FX.

Gut. 2016 Mar;65(3):476-86. doi: 10.1136/gutjnl-2014-308042. Epub 2015 Jan 16.

PMID:
25596178
19.

Bmi1 is required for regeneration of the exocrine pancreas in mice.

Fukuda A, Morris JP 4th, Hebrok M.

Gastroenterology. 2012 Sep;143(3):821-831.e2. doi: 10.1053/j.gastro.2012.05.009. Epub 2012 May 17.

20.

Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.

Bombardo M, Malagola E, Chen R, Rudnicka A, Graf R, Sonda S.

Br J Pharmacol. 2018 Jan;175(2):335-347. doi: 10.1111/bph.13867. Epub 2017 Jun 16.

PMID:
28542719

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