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Items: 1 to 20 of 127

1.

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD.

J Pathol. 2017 Sep;243(1):65-77. doi: 10.1002/path.4928. Epub 2017 Jul 27.

2.

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.

He P, Yang JW, Yang VW, Bialkowska AB.

Gastroenterology. 2018 Apr;154(5):1494-1508.e13. doi: 10.1053/j.gastro.2017.12.005. Epub 2017 Dec 15.

PMID:
29248441
3.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

4.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.

Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF.

Oncogene. 2013 Apr 11;32(15):1950-8. doi: 10.1038/onc.2012.210. Epub 2012 Jun 4.

5.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

6.

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.

7.

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model.

Hidalgo-Sastre A, Brodylo RL, Lubeseder-Martellato C, Sipos B, Steiger K, Lee M, von Figura G, Grünwald B, Zhong S, Trajkovic-Arsic M, Neff F, Schmid RM, Siveke JT.

Am J Pathol. 2016 Nov;186(11):2934-2944. doi: 10.1016/j.ajpath.2016.07.025. Epub 2016 Sep 14.

PMID:
27639167
8.

Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia.

Ebine K, Chow CR, DeCant BT, Hattaway HZ, Grippo PJ, Kumar K, Munshi HG.

Sci Rep. 2016 Jul 1;6:29133. doi: 10.1038/srep29133.

9.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

10.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
12.

Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma.

Avila JL, Troutman S, Durham A, Kissil JL.

PLoS One. 2012;7(12):e52133. doi: 10.1371/journal.pone.0052133. Epub 2012 Dec 19.

13.

Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice.

Bai H, Li H, Zhang W, Matkowskyj KA, Liao J, Srivastava SK, Yang GY.

Carcinogenesis. 2011 Nov;32(11):1689-96. doi: 10.1093/carcin/bgr191. Epub 2011 Aug 22.

14.

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.

Lubeseder-Martellato C, Alexandrow K, Hidalgo-Sastre A, Heid I, Boos SL, Briel T, Schmid RM, Siveke JT.

EBioMedicine. 2017 Feb;15:90-99. doi: 10.1016/j.ebiom.2016.12.013. Epub 2016 Dec 24.

15.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
16.

p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.

Grabliauskaite K, Hehl AB, Seleznik GM, Saponara E, Schlesinger K, Zuellig RA, Dittmann A, Bain M, Reding T, Sonda S, Graf R.

J Pathol. 2015 Feb;235(3):502-14. doi: 10.1002/path.4440. Epub 2014 Nov 6.

17.

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.

Gruber R, Panayiotou R, Nye E, Spencer-Dene B, Stamp G, Behrens A.

Gastroenterology. 2016 Sep;151(3):526-39. doi: 10.1053/j.gastro.2016.05.006. Epub 2016 May 20.

18.

Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.

Grabliauskaite K, Saponara E, Reding T, Bombardo M, Seleznik GM, Malagola E, Zabel A, Faso C, Sonda S, Graf R.

J Pathol. 2016 Feb;238(3):434-45. doi: 10.1002/path.4666. Epub 2015 Nov 28.

PMID:
26510396
19.

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4020-E4029. doi: 10.1073/pnas.1616060114. Epub 2017 May 1.

20.

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006.

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