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Items: 1 to 20 of 90

1.

Cannabidiol Reduces Leukemic Cell Size - But Is It Important?

Kalenderoglou N, Macpherson T, Wright KL.

Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.

2.

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ.

Cancer Res. 1999 Feb 15;59(4):886-94.

3.

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.

McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M.

Mol Pharmacol. 2006 Sep;70(3):897-908. Epub 2006 Jun 5.

4.

Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells.

Spampatti M, Vlotides G, Spöttl G, Maurer J, Göke B, Auernhammer CJ.

World J Gastroenterol. 2014 Aug 7;20(29):10038-49. doi: 10.3748/wjg.v20.i29.10038.

5.
6.

Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis.

Giacoppo S, Pollastro F, Grassi G, Bramanti P, Mazzon E.

Fitoterapia. 2017 Jan;116:77-84. doi: 10.1016/j.fitote.2016.11.010. Epub 2016 Nov 25.

PMID:
27890794
7.

Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors.

Batista A, Barata JT, Raderschall E, Sallan SE, Carlesso N, Nadler LM, Cardoso AA.

Exp Hematol. 2011 Apr;39(4):457-472.e3. doi: 10.1016/j.exphem.2011.01.005. Epub 2011 Jan 26.

PMID:
21277936
8.

Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis.

Fumarola C, La Monica S, Alfieri RR, Borra E, Guidotti GG.

Cell Death Differ. 2005 Oct;12(10):1344-57.

9.

Cannabinoid receptor 1 and acute resistance exercise--In vivo and in vitro studies in human skeletal muscle.

Pekkala S, Wiklund P, Hulmi JJ, Pöllänen E, Marjomäki V, Munukka E, Pierre P, Mouly V, Mero A, Alén M, Cheng S.

Peptides. 2015 May;67:55-63. doi: 10.1016/j.peptides.2015.03.007. Epub 2015 Mar 18.

PMID:
25796352
11.

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.

Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A.

Mol Cancer Ther. 2011 Jul;10(7):1161-72. doi: 10.1158/1535-7163.MCT-10-1100. Epub 2011 May 12.

12.

Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro.

Gorshtein A, Rubinfeld H, Kendler E, Theodoropoulou M, Cerovac V, Stalla GK, Cohen ZR, Hadani M, Shimon I.

Endocr Relat Cancer. 2009 Sep;16(3):1017-27. doi: 10.1677/ERC-08-0269. Epub 2009 Jun 9.

PMID:
19509067
13.

Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival.

Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL, Desprez PY, McAllister SD.

Mol Cancer Ther. 2010 Jan;9(1):180-9. doi: 10.1158/1535-7163.MCT-09-0407. Epub 2010 Jan 6.

14.

Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.

Jia W, Hegde VL, Singh NP, Sisco D, Grant S, Nagarkatti M, Nagarkatti PS.

Mol Cancer Res. 2006 Aug;4(8):549-62.

15.

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.

Clin Cancer Res. 2004 Dec 1;10(23):8059-67.

16.

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.

McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, Almanza C, Pakdel A, Lee J, Limbad C, Liu Y, Debs RJ, Moore DH, Desprez PY.

Breast Cancer Res Treat. 2011 Aug;129(1):37-47. doi: 10.1007/s10549-010-1177-4. Epub 2010 Sep 22. Erratum in: Breast Cancer Res Treat. 2012 May;133(1):401-4.

17.

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells.

Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA.

J Neurochem. 2004 Apr;89(1):134-41.

18.

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.

Chiarini F, Falà F, Tazzari PL, Ricci F, Astolfi A, Pession A, Pagliaro P, McCubrey JA, Martelli AM.

Cancer Res. 2009 Apr 15;69(8):3520-8. doi: 10.1158/0008-5472.CAN-08-4884. Epub 2009 Apr 7.

19.

Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma.

Peponi E, Drakos E, Reyes G, Leventaki V, Rassidakis GZ, Medeiros LJ.

Am J Pathol. 2006 Dec;169(6):2171-80.

20.

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.

Ramer R, Merkord J, Rohde H, Hinz B.

Biochem Pharmacol. 2010 Apr 1;79(7):955-66. doi: 10.1016/j.bcp.2009.11.007. Epub 2009 Nov 13.

PMID:
19914218

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