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The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from mitochondrial connexin 43.

Boengler K, Bulic M, Schreckenberg R, Schlüter KD, Schulz R.

Br J Pharmacol. 2017 Jul;174(13):2060-2073. doi: 10.1111/bph.13804. Epub 2017 May 10.


The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent.

Srisakuldee W, Makazan Z, Nickel BE, Zhang F, Thliveris JA, Pasumarthi KB, Kardami E.

Cardiovasc Res. 2014 Jul 1;103(1):72-80. doi: 10.1093/cvr/cvu066. Epub 2014 Mar 20.


The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs.

Skyschally A, Walter B, Schultz Hansen R, Heusch G.

Naunyn Schmiedebergs Arch Pharmacol. 2013 May;386(5):383-91. doi: 10.1007/s00210-013-0840-9. Epub 2013 Feb 9.


Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria.

Boengler K, Stahlhofen S, van de Sand A, Gres P, Ruiz-Meana M, Garcia-Dorado D, Heusch G, Schulz R.

Basic Res Cardiol. 2009 Mar;104(2):141-7. doi: 10.1007/s00395-009-0007-5. Epub 2009 Feb 26.


S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function.

Soetkamp D, Nguyen TT, Menazza S, Hirschhäuser C, Hendgen-Cotta UB, Rassaf T, Schlüter KD, Boengler K, Murphy E, Schulz R.

Basic Res Cardiol. 2014;109(5):433. doi: 10.1007/s00395-014-0433-x. Epub 2014 Aug 13.


Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption.

Boengler K, Ruiz-Meana M, Gent S, Ungefug E, Soetkamp D, Miro-Casas E, Cabestrero A, Fernandez-Sanz C, Semenzato M, Di Lisa F, Rohrbach S, Garcia-Dorado D, Heusch G, Schulz R.

J Cell Mol Med. 2012 Aug;16(8):1649-55. doi: 10.1111/j.1582-4934.2011.01516.x.


ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design.

DeLalio LJ, Isakson BE.

Br J Pharmacol. 2017 Aug;174(15):2606-2607. doi: 10.1111/bph.13891. Epub 2017 Jul 9.


Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury.

Ruiz-Meana M, Rodríguez-Sinovas A, Cabestrero A, Boengler K, Heusch G, Garcia-Dorado D.

Cardiovasc Res. 2008 Jan 15;77(2):325-33. Epub 2007 Nov 9.


Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion.

Chen Q, Moghaddas S, Hoppel CL, Lesnefsky EJ.

J Pharmacol Exp Ther. 2006 Dec;319(3):1405-12. Epub 2006 Sep 21.


Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.

Chen Q, Moghaddas S, Hoppel CL, Lesnefsky EJ.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C460-6. Epub 2007 Dec 12.


Rat cardiac mitochondrial sub-populations show distinct features of oxidative phosphorylation during ischemia, reperfusion and ischemic preconditioning.

Kurian GA, Berenshtein E, Saada A, Chevion M.

Cell Physiol Biochem. 2012;30(1):83-94. doi: 10.1159/000339043. Epub 2012 Jun 8.


Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

Wang N, De Vuyst E, Ponsaerts R, Boengler K, Palacios-Prado N, Wauman J, Lai CP, De Bock M, Decrock E, Bol M, Vinken M, Rogiers V, Tavernier J, Evans WH, Naus CC, Bukauskas FF, Sipido KR, Heusch G, Schulz R, Bultynck G, Leybaert L.

Basic Res Cardiol. 2013 Jan;108(1):309. doi: 10.1007/s00395-012-0309-x. Epub 2012 Nov 8.


Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl2-induced apoptotic response in a chemical model of hypoxia.

Pecoraro M, Pinto A, Popolo A.

Toxicol In Vitro. 2018 Mar;47:120-128. doi: 10.1016/j.tiv.2017.11.004. Epub 2017 Nov 16.


Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels.

Rottlaender D, Boengler K, Wolny M, Schwaiger A, Motloch LJ, Ovize M, Schulz R, Heusch G, Hoppe UC.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E242-51. doi: 10.1073/pnas.1107479109. Epub 2012 Jan 11. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13131. Retraction in: Rottlaender D, Boengler K, Wolny M, Schwaiger A, Motloch LJ, Ovize M, Schulz R, Heusch G, Hoppe UC. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21552.


Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury.

Banu SA, Ravindran S, Kurian GA.

Cell Stress Chaperones. 2016 Jul;21(4):571-82. doi: 10.1007/s12192-016-0682-8. Epub 2016 Mar 7.


Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice.

Heinzel FR, Luo Y, Li X, Boengler K, Buechert A, García-Dorado D, Di Lisa F, Schulz R, Heusch G.

Circ Res. 2005 Sep 16;97(6):583-6. Epub 2005 Aug 11.


Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes.

Martins-Marques T, Catarino S, Zuzarte M, Marques C, Matafome P, Pereira P, Girão H.

Biochem J. 2015 Apr 15;467(2):231-45. doi: 10.1042/BJ20141370.


Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43.

Boengler K, Konietzka I, Buechert A, Heinen Y, Garcia-Dorado D, Heusch G, Schulz R.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1764-9. Epub 2006 Dec 1.


Connexin 43 and Mitochondria in Cardiovascular Health and Disease.

Boengler K, Schulz R.

Adv Exp Med Biol. 2017;982:227-246. doi: 10.1007/978-3-319-55330-6_12. Review.


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