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Items: 1 to 20 of 101

1.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5202-5207. doi: 10.1002/anie.201611750. Epub 2017 Mar 23.

PMID:
28334491
2.

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7389.

PMID:
24446188
3.

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.

Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.

Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260.

PMID:
28934390
4.

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.

Chaibva M, Jawahery S, Pilkington AW 4th, Arndt JR, Sarver O, Valentine S, Matysiak S, Legleiter J.

Biophys J. 2016 Jul 26;111(2):349-362. doi: 10.1016/j.bpj.2016.06.018.

5.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

DeGuire SM, Ruggeri FS, Fares MB, Chiki A, Cendrowska U, Dietler G, Lashuel HA.

J Biol Chem. 2018 Nov 30;293(48):18540-18558. doi: 10.1074/jbc.RA118.004621. Epub 2018 Sep 5.

6.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818. doi: 10.1073/pnas.1705372114. Epub 2017 Nov 21.

7.

Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.

Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB.

Biochemistry. 2017 Jul 18;56(28):3579-3586. doi: 10.1021/acs.biochem.7b00138. Epub 2017 Jul 7.

8.

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy.

Reif A, Chiki A, Ricci J, Lashuel HA.

J Vis Exp. 2018 Jun 27;(136). doi: 10.3791/57506.

9.

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms.

Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R.

J Biol Chem. 2018 Feb 16;293(7):2597-2605. doi: 10.1074/jbc.M117.813667. Epub 2017 Dec 27.

PMID:
29282287
10.

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.

Arndt JR, Chaibva M, Legleiter J.

Biomol Concepts. 2015 Mar;6(1):33-46. doi: 10.1515/bmc-2015-0001. Review.

11.

Calmidazolium Chloride and Its Complex with Serum Albumin Prevent Huntingtin Exon1 Aggregation.

Singh V, Deepak RNVK, Sengupta B, Joshi AS, Fan H, Sen P, Thakur AK.

Mol Pharm. 2018 Aug 6;15(8):3356-3368. doi: 10.1021/acs.molpharmaceut.8b00380. Epub 2018 Jul 19.

PMID:
29979597
12.

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM.

Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23.

PMID:
28743452
13.

Gpd1 Regulates the Activity of Tcp-1 and Heat Shock Response in Yeast Cells: Effect on Aggregation of Mutant Huntingtin.

Bhadra AK, Roy I.

Mol Neurobiol. 2016 Aug;53(6):3900-3913. doi: 10.1007/s12035-015-9329-5. Epub 2015 Jul 12.

PMID:
26164272
14.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett TR, Rau F, O'Driscoll J, Patani R, Lowe AR, Saibil HR.

Mol Cell. 2018 May 17;70(4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. Epub 2018 May 10.

15.

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.

Arbez N, Ratovitski T, Roby E, Chighladze E, Stewart JC, Ren M, Wang X, Lavery DJ, Ross CA.

J Biol Chem. 2017 Nov 24;292(47):19238-19249. doi: 10.1074/jbc.M117.782300. Epub 2017 Sep 27.

16.

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA.

Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462.

17.

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.

18.

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

Mishra R, Hoop CL, Kodali R, Sahoo B, van der Wel PC, Wetzel R.

J Mol Biol. 2012 Nov 23;424(1-2):1-14. doi: 10.1016/j.jmb.2012.09.011. Epub 2012 Sep 18.

19.

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.

Büning S, Sharma A, Vachharajani S, Newcombe E, Ormsby A, Gao M, Gnutt D, Vöpel T, Hatters DM, Ebbinghaus S.

Phys Chem Chem Phys. 2017 May 3;19(17):10738-10747. doi: 10.1039/c6cp08167c.

PMID:
28094373

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