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Items: 1 to 20 of 95

1.

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C.

Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063.

2.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.

Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF.

Sci Adv. 2016 Sep 2;2(9):e1601167. doi: 10.1126/sciadv.1601167. eCollection 2016 Sep.

3.

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.

Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F.

Acta Neuropathol Commun. 2016 May 18;4(1):51. doi: 10.1186/s40478-016-0324-5.

4.

Multifaceted role of SMCR8 as autophagy regulator.

Jung J, Behrends C.

Small GTPases. 2017 Jul 11:1-9. doi: 10.1080/21541248.2017.1346553. [Epub ahead of print]

PMID:
28696821
5.

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ.

EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22.

6.

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.

Park JM, Jung CH, Seo M, Otto NM, Grunwald D, Kim KH, Moriarity B, Kim YM, Starker C, Nho RS, Voytas D, Kim DH.

Autophagy. 2016;12(3):547-64. doi: 10.1080/15548627.2016.1140293.

7.

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K.

Genes Dev. 2018 Jul 1;32(13-14):929-943. doi: 10.1101/gad.313932.118. Epub 2018 Jun 27.

8.

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.

Webster CP, Smith EF, Grierson AJ, De Vos KJ.

Small GTPases. 2018 Sep 3;9(5):399-408. doi: 10.1080/21541248.2016.1240495. Epub 2016 Oct 21. Review.

9.

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.

Kraft C, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, Stoffel I, Brezovich A, Verma M, Hansmann I, Ammerer G, Hofmann K, Tooze S, Peter M.

EMBO J. 2012 Sep 12;31(18):3691-703. doi: 10.1038/emboj.2012.225. Epub 2012 Aug 10.

10.

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy.

Wang C, Wang H, Zhang D, Luo W, Liu R, Xu D, Diao L, Liao L, Liu Z.

Nat Commun. 2018 Aug 28;9(1):3492. doi: 10.1038/s41467-018-05449-1.

11.

Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex.

Papinski D, Kraft C.

J Mol Biol. 2016 May 8;428(9 Pt A):1725-41. doi: 10.1016/j.jmb.2016.03.030. Epub 2016 Apr 6. Review.

12.

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.

Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA.

J Cell Biol. 2012 May 28;197(5):659-75. doi: 10.1083/jcb.201111079. Epub 2012 May 21.

13.

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.

Ugolino J, Ji YJ, Conchina K, Chu J, Nirujogi RS, Pandey A, Brady NR, Hamacher-Brady A, Wang J.

PLoS Genet. 2016 Nov 22;12(11):e1006443. doi: 10.1371/journal.pgen.1006443. eCollection 2016 Nov.

14.

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.

Wold MS, Lim J, Lachance V, Deng Z, Yue Z.

Mol Neurodegener. 2016 Dec 9;11(1):76.

15.

Study of ULK1 Catalytic Activity and Its Regulation.

Stork B, Dengjel J.

Methods Enzymol. 2017;587:391-404. doi: 10.1016/bs.mie.2016.09.067. Epub 2016 Nov 18.

PMID:
28253968
16.

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

Orsi A, Razi M, Dooley HC, Robinson D, Weston AE, Collinson LM, Tooze SA.

Mol Biol Cell. 2012 May;23(10):1860-73. doi: 10.1091/mbc.E11-09-0746. Epub 2012 Mar 28.

17.

Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation.

Allavena G, Boyd C, Oo KS, Maellaro E, Zhivotovsky B, Kaminskyy VO.

Autophagy. 2016 Nov;12(11):2085-2097. Epub 2016 Sep 14.

18.

Downregulation of ULK1 by microRNA-372 inhibits the survival of human pancreatic adenocarcinoma cells.

Chen H, Zhang Z, Lu Y, Song K, Liu X, Xia F, Sun W.

Cancer Sci. 2017 Sep;108(9):1811-1819. doi: 10.1111/cas.13315. Epub 2017 Aug 10.

19.

The association of AMPK with ULK1 regulates autophagy.

Lee JW, Park S, Takahashi Y, Wang HG.

PLoS One. 2010 Nov 3;5(11):e15394. doi: 10.1371/journal.pone.0015394.

20.

Mechanisms of Autophagy Initiation.

Hurley JH, Young LN.

Annu Rev Biochem. 2017 Jun 20;86:225-244. doi: 10.1146/annurev-biochem-061516-044820. Epub 2017 Mar 15. Review.

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