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Items: 1 to 20 of 96

1.

A water-mediated allosteric network governs activation of Aurora kinase A.

Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM.

Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6.

2.

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2.

Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ, Kern D.

Elife. 2014 May 27;3:e02667. doi: 10.7554/eLife.02667.

3.

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM.

Elife. 2018 Feb 21;7. pii: e32766. doi: 10.7554/eLife.32766.

5.

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG.

ACS Chem Biol. 2016 Dec 16;11(12):3383-3390. Epub 2016 Nov 1.

6.

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R.

Open Biol. 2016 Jul;6(7). pii: 160089. doi: 10.1098/rsob.160089.

7.

Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.

Chen H, Mohan P, Jiang J, Nemirovsky O, He D, Fleisch MC, Niederacher D, Pilarski LM, Lim CJ, Maxwell CA.

Cell Cycle. 2014;13(14):2248-61. doi: 10.4161/cc.29270. Epub 2014 May 29.

8.

A novel mechanism for activation of the protein kinase Aurora A.

Eyers PA, Erikson E, Chen LG, Maller JL.

Curr Biol. 2003 Apr 15;13(8):691-7.

9.

Issues in interpreting the in vivo activity of Aurora-A.

Shagisultanova E, Dunbrack RL Jr, Golemis EA.

Expert Opin Ther Targets. 2015 Feb;19(2):187-200. doi: 10.1517/14728222.2014.981154. Epub 2014 Nov 11. Review.

10.

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Ruan Z, Katiyar S, Kannan N.

Biochemistry. 2017 Jan 10;56(1):22-32. doi: 10.1021/acs.biochem.6b00572. Epub 2016 Dec 22.

11.

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.

Bayliss R, Sardon T, Vernos I, Conti E.

Mol Cell. 2003 Oct;12(4):851-62.

12.

Allosteric inhibition of c-Met kinase in sub-microsecond molecular dynamics simulations induced by its inhibitor, tivantinib.

Yan M, Wang H, Wang Q, Zhang Z, Zhang C.

Phys Chem Chem Phys. 2016 Apr 21;18(15):10367-74. doi: 10.1039/c5cp07001e. Epub 2016 Mar 31.

PMID:
27029952
13.

Evidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle.

Kang Q, Srividhya J, Ipe J, Pomerening JR.

J Biol Chem. 2014 Jun 20;289(25):17480-96. doi: 10.1074/jbc.M113.527622. Epub 2014 May 13.

14.

A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.

Bertolin G, Sizaire F, Herbomel G, Reboutier D, Prigent C, Tramier M.

Nat Commun. 2016 Sep 14;7:12674. doi: 10.1038/ncomms12674.

15.

Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic.

Dodson CA, Bayliss R.

J Biol Chem. 2012 Jan 6;287(2):1150-7. doi: 10.1074/jbc.M111.312090. Epub 2011 Nov 16.

16.

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Zeng K, Bastos RN, Barr FA, Gruneberg U.

J Cell Biol. 2010 Dec 27;191(7):1315-32. doi: 10.1083/jcb.201008106.

17.

A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.

Mahankali M, Henkels KM, Speranza F, Gomez-Cambronero J.

J Cell Sci. 2015 Feb 1;128(3):516-26.

18.

Insights into Aurora-A kinase activation using unnatural amino acids incorporated by chemical modification.

Rowan FC, Richards M, Bibby RA, Thompson A, Bayliss R, Blagg J.

ACS Chem Biol. 2013 Oct 18;8(10):2184-91. doi: 10.1021/cb400425t. Epub 2013 Aug 7.

19.

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.

Eyers PA, Churchill ME, Maller JL.

Cell Cycle. 2005 Jun;4(6):784-9. Epub 2005 Jun 7.

PMID:
15908779
20.

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E.

ACS Chem Biol. 2012 Apr 20;7(4):698-706. doi: 10.1021/cb200508b. Epub 2012 Jan 27.

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