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Items: 1 to 20 of 100

1.

The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.

Huang ZN, Her LS.

Mol Neurobiol. 2017 Nov;54(9):7382-7400. doi: 10.1007/s12035-016-0247-y. Epub 2016 Nov 5.

PMID:
27815841
2.

Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.

Huang ZN, Chung HM, Fang SC, Her LS.

Int J Biol Sci. 2017 Nov 1;13(11):1420-1437. doi: 10.7150/ijbs.20742. eCollection 2017.

3.

Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.

Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S.

Hum Mol Genet. 2010 Jun 15;19(12):2445-55. doi: 10.1093/hmg/ddq127. Epub 2010 Mar 30.

4.

Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.

Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D, Korhonen L.

Hum Mol Genet. 2014 Nov 15;23(22):5928-39. doi: 10.1093/hmg/ddu317. Epub 2014 Jun 20.

PMID:
24951540
5.

Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.

Lin L, Jin Z, Tan H, Xu Q, Peng T, Li H.

Brain Res. 2016 Jul 15;1643:103-12. doi: 10.1016/j.brainres.2016.03.027. Epub 2016 Apr 21.

PMID:
27107943
6.

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ.

J Cell Biol. 2008 Mar 24;180(6):1177-89. doi: 10.1083/jcb.200709080.

7.

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

Chow WN, Luk HW, Chan HY, Lau KF.

Biochem J. 2012 May 1;443(3):681-9. doi: 10.1042/BJ20112175.

PMID:
22352297
8.

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain.

Díaz-Hernández M, Valera AG, Morán MA, Gómez-Ramos P, Alvarez-Castelao B, Castaño JG, Hernández F, Lucas JJ.

J Neurochem. 2006 Sep;98(5):1585-96. Epub 2006 Jun 19.

9.

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models.

Her LS, Lin JY, Fu MH, Chang YF, Li CL, Tang TY, Jhang YL, Chang CY, Shih MC, Cheng PH, Yang SH.

Brain Pathol. 2015 Jul;25(4):481-90. doi: 10.1111/bpa.12191. Epub 2014 Nov 6.

PMID:
25178567
10.

Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease.

Hunter JM, Lesort M, Johnson GV.

J Neurosci Res. 2007 Jun;85(8):1774-88.

PMID:
17455294
11.

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.

Tydlacka S, Wang CE, Wang X, Li S, Li XJ.

J Neurosci. 2008 Dec 3;28(49):13285-95. doi: 10.1523/JNEUROSCI.4393-08.2008.

12.

Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones.

Luo H, Cao L, Liang X, Du A, Peng T, Li H.

Mol Neurobiol. 2018 Oct;55(10):7652-7668. doi: 10.1007/s12035-018-0900-8. Epub 2018 Feb 12.

PMID:
29430620
13.

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.

Chiang MC, Chen HM, Lai HL, Chen HW, Chou SY, Chen CM, Tsai FJ, Chern Y.

Hum Mol Genet. 2009 Aug 15;18(16):2929-42. doi: 10.1093/hmg/ddp230. Epub 2009 May 14.

PMID:
19443488
14.
15.

Clearance of mutant huntingtin.

Li XJ, Li H, Li S.

Autophagy. 2010 Jul;6(5):663-4. doi: 10.4161/auto.6.5.12336.

16.

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.

van Hagen M, Piebes DGE, de Leeuw WC, Vuist IM, van Roon-Mom WMC, Moerland PD, Verschure PJ.

BMC Genomics. 2017 May 12;18(1):373. doi: 10.1186/s12864-017-3745-z.

18.
19.

Global changes to the ubiquitin system in Huntington's disease.

Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR.

Nature. 2007 Aug 9;448(7154):704-8.

PMID:
17687326
20.

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.

Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Díaz-Hernández M, Brundin P, Overkleeft HS, Li JY, Lucas JJ, Dantuma NP.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13986-91. doi: 10.1073/pnas.0906463106. Epub 2009 Jul 30.

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