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Items: 1 to 20 of 109

1.
2.
3.

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

Showalter SA, Bruschweiler-Li L, Johnson E, Zhang F, Br├╝schweiler R.

J Am Chem Soc. 2008 May 21;130(20):6472-8. doi: 10.1021/ja800201j. Epub 2008 Apr 25.

PMID:
18435534
4.

Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.

Pantelopulos GA, Mukherjee S, Voelz VA.

Proteins. 2015 Sep;83(9):1665-76. doi: 10.1002/prot.24852. Epub 2015 Jul 21.

PMID:
26138282
5.

Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction.

Ciemny MP, Debinski A, Paczkowska M, Kolinski A, Kurcinski M, Kmiecik S.

Sci Rep. 2016 Dec 1;6:37532. doi: 10.1038/srep37532.

6.

Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2.

Bueren-Calabuig JA, Michel J.

PLoS Comput Biol. 2015 Jun 5;11(6):e1004282. doi: 10.1371/journal.pcbi.1004282. eCollection 2015 Jun.

7.

Binding induced folding in p53-MDM2 complex.

Chen HF, Luo R.

J Am Chem Soc. 2007 Mar 14;129(10):2930-7. Epub 2007 Feb 16.

8.

Bridging Microscopic and Macroscopic Mechanisms of p53-MDM2 Binding with Kinetic Network Models.

Zhou G, Pantelopulos GA, Mukherjee S, Voelz VA.

Biophys J. 2017 Aug 22;113(4):785-793. doi: 10.1016/j.bpj.2017.07.009.

9.

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100.

Dastidar SG, Lane DP, Verma CS.

BMC Bioinformatics. 2009 Dec 3;10 Suppl 15:S6. doi: 10.1186/1471-2105-10-S15-S6.

10.

Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations.

Xiong K, Zwier MC, Myshakina NS, Burger VM, Asher SA, Chong LT.

J Phys Chem A. 2011 Sep 1;115(34):9520-7. doi: 10.1021/jp112235d. Epub 2011 Apr 29.

11.

Conformational changes of the p53-binding cleft of MDM2 revealed by molecular dynamics simulations.

Espinoza-Fonseca LM, Trujillo-Ferrara JG.

Biopolymers. 2006 Nov;83(4):365-73.

PMID:
16817233
12.

Impact of Ser17 Phosphorylation on the Conformational Dynamics of the Oncoprotein MDM2.

Bueren-Calabuig JA, Michel J.

Biochemistry. 2016 May 3;55(17):2500-9. doi: 10.1021/acs.biochem.6b00127. Epub 2016 Apr 18.

PMID:
27050388
13.

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2.

Dastidar SG, Lane DP, Verma CS.

J Am Chem Soc. 2008 Oct 15;130(41):13514-5. doi: 10.1021/ja804289g. Epub 2008 Sep 19.

PMID:
18800837
14.

Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation.

Dastidar SG, Raghunathan D, Nicholson J, Hupp TR, Lane DP, Verma CS.

Cell Cycle. 2011 Jan 1;10(1):82-9. Epub 2011 Jan 1.

PMID:
21191186
15.

C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms.

Brown CJ, Dastidar SG, Quah ST, Lim A, Chia B, Verma CS.

PLoS One. 2011;6(8):e24122. doi: 10.1371/journal.pone.0024122. Epub 2011 Aug 31.

16.

Anchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein.

Huang Y, Liu Z.

Int J Mol Sci. 2011 Feb 23;12(2):1410-30. doi: 10.3390/ijms12021410.

17.

Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study.

Patil SP, Pacitti MF, Gilroy KS, Ruggiero JC, Griffin JD, Butera JJ, Notarfrancesco JM, Tran S, Stoddart JW.

J Comput Aided Mol Des. 2015 Feb;29(2):155-63. doi: 10.1007/s10822-014-9811-6. Epub 2014 Nov 7.

PMID:
25377899
18.

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4665-70. doi: 10.1073/pnas.0900947106. Epub 2009 Mar 2.

19.

Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.

Lee HJ, Srinivasan D, Coomber D, Lane DP, Verma CS.

Cell Cycle. 2007 Nov 1;6(21):2604-11. Epub 2007 Aug 20.

PMID:
17957142
20.

The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.

Worrall EG, Worrall L, Blackburn E, Walkinshaw M, Hupp TR.

J Mol Biol. 2010 May 7;398(3):414-28. doi: 10.1016/j.jmb.2010.03.023. Epub 2010 Mar 19.

PMID:
20303977

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