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Items: 1 to 20 of 101

1.

Metabolic signatures of Huntington's disease (HD): (1)H NMR analysis of the polar metabolome in post-mortem human brain.

Graham SF, Kumar PK, Bjorndahl T, Han B, Yilmaz A, Sherman E, Bahado-Singh RO, Wishart D, Mann D, Green BD.

Biochim Biophys Acta. 2016 Sep;1862(9):1675-84. doi: 10.1016/j.bbadis.2016.06.007. Epub 2016 Jun 8.

2.

Novel Metabolite Biomarkers of Huntington's Disease As Detected by High-Resolution Mass Spectrometry.

Graham SF, Kumar P, Bahado-Singh RO, Robinson A, Mann D, Green BD.

J Proteome Res. 2016 May 6;15(5):1592-601. doi: 10.1021/acs.jproteome.6b00049. Epub 2016 Mar 28.

PMID:
27018767
3.

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.

4.

Targeted biochemical profiling of brain from Huntington's disease patients reveals novel metabolic pathways of interest.

Graham SF, Pan X, Yilmaz A, Macias S, Robinson A, Mann D, Green BD.

Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2430-2437. doi: 10.1016/j.bbadis.2018.04.012. Epub 2018 Apr 21.

PMID:
29684586
5.

Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11.

6.

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

Carroll JB, Deik A, Fossale E, Weston RM, Guide JR, Arjomand J, Kwak S, Clish CB, MacDonald ME.

PLoS One. 2015 Aug 21;10(8):e0134465. doi: 10.1371/journal.pone.0134465. eCollection 2015.

7.

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.

P├ępin J, Francelle L, Carrillo-de Sauvage MA, de Longprez L, Gipchtein P, Cambon K, Valette J, Brouillet E, Flament J.

Neuroimage. 2016 Oct 1;139:53-64. doi: 10.1016/j.neuroimage.2016.06.023. Epub 2016 Jun 16.

8.

NMR Spectroscopy-based Metabolomics of Drosophila Model of Huntington's Disease Suggests Altered Cell Energetics.

Singh V, Sharma RK, Athilingam T, Sinha P, Sinha N, Thakur AK.

J Proteome Res. 2017 Oct 6;16(10):3863-3872. doi: 10.1021/acs.jproteome.7b00491. Epub 2017 Sep 26.

PMID:
28871787
9.

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.

Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR.

Mov Disord. 2015 Mar;30(3):393-401. doi: 10.1002/mds.26118. Epub 2015 Feb 18.

PMID:
25690257
10.

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers.

Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ.

Neurology. 1998 May;50(5):1357-65.

PMID:
9595987
11.
12.

Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy.

Tkac I, Dubinsky JM, Keene CD, Gruetter R, Low WC.

J Neurochem. 2007 Mar;100(5):1397-406. Epub 2007 Jan 8.

13.

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Patassini S, Begley P, Reid SJ, Xu J, Church SJ, Curtis M, Dragunow M, Waldvogel HJ, Unwin RD, Snell RG, Faull RL, Cooper GJ.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):161-6. doi: 10.1016/j.bbrc.2015.10.140. Epub 2015 Oct 30.

PMID:
26522227
14.

Reduced striatal [3H]inositol 1,4,5-trisphosphate binding in Huntington's disease.

Warsh JJ, Politsky JM, Li PP, Kish SJ, Hornykiewicz O.

J Neurochem. 1991 Apr;56(4):1417-22.

PMID:
1825844
15.
16.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

17.

Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.

Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ.

Neuroscience. 2006 Aug 25;141(2):569-84. Epub 2006 May 22.

PMID:
16716524
18.

Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease.

Louis Sam Titus ASC, Yusuff T, Cassar M, Thomas E, Kretzschmar D, D'Mello SR.

J Neurosci. 2017 Jul 5;37(27):6575-6587. doi: 10.1523/JNEUROSCI.3612-16.2017. Epub 2017 May 26.

19.

Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.

Vodicka P, Mo S, Tousley A, Green KM, Sapp E, Iuliano M, Sadri-Vakili G, Shaffer SA, Aronin N, DiFiglia M, Kegel-Gleason KB.

J Huntingtons Dis. 2015;4(2):187-201. doi: 10.3233/JHD-150149.

PMID:
26397899
20.

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