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Items: 1 to 20 of 162

1.

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.

Jung J, Genau HM, Behrends C.

Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11.

2.

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM.

Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7.

3.

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G.

Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7.

4.

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

Shen K, Sabatini DM.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9545-9550. doi: 10.1073/pnas.1811727115. Epub 2018 Sep 4.

PMID:
30181260
5.

The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.

Jin M, Klionsky DJ.

Autophagy. 2015;11(10):1709-10. doi: 10.1080/15548627.2015.1084461.

6.

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.

7.

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Oshiro N, Rapley J, Avruch J.

J Biol Chem. 2014 Jan 31;289(5):2658-74. doi: 10.1074/jbc.M113.528505. Epub 2013 Dec 11.

8.

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.

Cell. 2017 Oct 19;171(3):642-654.e12. doi: 10.1016/j.cell.2017.09.046.

9.

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Ögmundsdóttir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, Shaw MK, Goberdhan DC.

PLoS One. 2012;7(5):e36616. doi: 10.1371/journal.pone.0036616. Epub 2012 May 4.

10.

Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.

PMID:
23863162
11.

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.

Rebsamen M, Superti-Furga G.

Autophagy. 2016 Jun 2;12(6):1061-2. doi: 10.1080/15548627.2015.1091143. Epub 2015 Oct 2.

12.

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R.

Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417.

13.

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

14.

Rag GTPase in amino acid signaling.

Kim J, Kim E.

Amino Acids. 2016 Apr;48(4):915-28. doi: 10.1007/s00726-016-2171-x. Epub 2016 Jan 18. Review.

PMID:
26781224
15.

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).

Shibutani S, Okazaki H, Iwata H.

J Biol Chem. 2017 Nov 3;292(44):18052-18061. doi: 10.1074/jbc.M117.776443. Epub 2017 Aug 14.

16.

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.

17.

Key mediators of intracellular amino acids signaling to mTORC1 activation.

Duan Y, Li F, Tan K, Liu H, Li Y, Liu Y, Kong X, Tang Y, Wu G, Yin Y.

Amino Acids. 2015 May;47(5):857-67. doi: 10.1007/s00726-015-1937-x. Epub 2015 Feb 21. Review.

PMID:
25701492
18.

Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.

J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22.

19.

Amino acid signalling upstream of mTOR.

Jewell JL, Russell RC, Guan KL.

Nat Rev Mol Cell Biol. 2013 Mar;14(3):133-9. doi: 10.1038/nrm3522. Epub 2013 Jan 30. Review.

20.

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.

PMID:
24793303

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