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Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding.

Kavian N, Marut W, Servettaz A, Nicco C, Chéreau C, Lemaréchal H, Guilpain P, Chimini G, Galland F, Weill B, Naquet P, Batteux F.

Arthritis Rheumatol. 2015 Jul;67(7):1881-90. doi: 10.1002/art.39121.


The organotelluride catalyst (PHTE)₂NQ prevents HOCl-induced systemic sclerosis in mouse.

Marut WK, Kavian N, Servettaz A, Nicco C, Ba LA, Doering M, Chéreau C, Jacob C, Weill B, Batteux F.

J Invest Dermatol. 2012 Apr;132(4):1125-32. doi: 10.1038/jid.2011.455. Epub 2012 Jan 26.


Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade.

Marut W, Kavian N, Servettaz A, Hua-Huy T, Nicco C, Chéreau C, Weill B, Dinh-Xuan AT, Batteux F.

Arthritis Rheum. 2013 May;65(5):1367-77. doi: 10.1002/art.37873.


Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis.

Akamata K, Asano Y, Taniguchi T, Yamashita T, Saigusa R, Nakamura K, Noda S, Aozasa N, Toyama T, Takahashi T, Ichimura Y, Sumida H, Tada Y, Sugaya M, Kadono T, Sato S.

Rheumatology (Oxford). 2015 Jul;54(7):1308-16. doi: 10.1093/rheumatology/keu479. Epub 2014 Dec 23.


Protection against cerebral malaria by the low-molecular-weight thiol pantethine.

Penet MF, Abou-Hamdan M, Coltel N, Cornille E, Grau GE, de Reggi M, Gharib B.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1321-6. doi: 10.1073/pnas.0706867105. Epub 2008 Jan 14.


Amelioration of tissue fibrosis by toll-like receptor 4 knockout in murine models of systemic sclerosis.

Takahashi T, Asano Y, Ichimura Y, Toyama T, Taniguchi T, Noda S, Akamata K, Tada Y, Sugaya M, Kadono T, Sato S.

Arthritis Rheumatol. 2015 Jan;67(1):254-65. doi: 10.1002/art.38901.


The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse.

Marut W, Jamier V, Kavian N, Servettaz A, Winyard PG, Eggleton P, Anwar A, Nicco C, Jacob C, Chéreau C, Weill B, Batteux F.

Arthritis Res Ther. 2013 Oct 28;15(5):R167. doi: 10.1186/ar4351.


Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development.

Lambrecht S, Smith V, De Wilde K, Coudenys J, Decuman S, Deforce D, De Keyser F, Elewaut D.

Arthritis Rheumatol. 2014 Feb;66(2):418-27. doi: 10.1002/art.38241.


Reactive oxygen species-mediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a murine model of systemic sclerosis.

Kavian N, Marut W, Servettaz A, Nicco C, Chéreau C, Lemaréchal H, Borderie D, Dupin N, Weill B, Batteux F.

Arthritis Rheum. 2012 Oct;64(10):3430-40. doi: 10.1002/art.34534.


RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.

Bei Y, Hua-Huy T, Nicco C, Duong-Quy S, Le-Dong NN, Tiev KP, Chéreau C, Batteux F, Dinh-Xuan AT.

Exp Lung Res. 2016;42(1):44-55. doi: 10.3109/01902148.2016.1141263.


Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis.

Bagnato G, Bitto A, Irrera N, Pizzino G, Sangari D, Cinquegrani M, Roberts W, Atteritano M, Altavilla D, Squadrito F, Bagnato G, Saitta A.

Arthritis Res Ther. 2013 Sep 16;15(5):R120. doi: 10.1186/ar4300. Erratum in: Arthritis Res Ther. 2014;16(2):406.


Therapeutic potential of human-induced pluripotent stem cell-derived endothelial cells in a bleomycin-induced scleroderma mouse model.

Azhdari M, Baghaban-Eslaminejad M, Baharvand H, Aghdami N.

Stem Cell Res. 2013 May;10(3):288-300. doi: 10.1016/j.scr.2012.12.004. Epub 2012 Dec 21.


2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation.

Zhu L, Song Y, Li M.

J Dermatol Sci. 2015 Jan;77(1):63-70. doi: 10.1016/j.jdermsci.2014.10.007. Epub 2014 Nov 3.


Bone Marrow-Derived Mesenchymal Stem Cells Expressing Thioredoxin 1 Attenuate Bleomycin-Induced Skin Fibrosis and Oxidative Stress in Scleroderma.

Jiang M, Yu Y, Luo J, Gao Q, Zhang L, Wang Q, Zhao J.

J Invest Dermatol. 2017 Jun;137(6):1223-1233. doi: 10.1016/j.jid.2017.01.011. Epub 2017 Jan 26.


Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Avouac J, Palumbo K, Tomcik M, Zerr P, Dees C, Horn A, Maurer B, Akhmetshina A, Beyer C, Sadowski A, Schneider H, Shiozawa S, Distler O, Schett G, Allanore Y, Distler JH.

Arthritis Rheum. 2012 May;64(5):1642-52. doi: 10.1002/art.33501.


Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice.

Song Y, Zhu L, Li M.

Clinics (Sao Paulo). 2013 Oct;68(10):1350-7. doi: 10.6061/clinics/2013(10)10.


Propylthiouracil modulates aortic vasculopathy in the oxidative stress model of systemic sclerosis.

Bagnato G, Bitto A, Pizzino G, Roberts WN, Squadrito F, Altavilla D, Bagnato G, Saitta A.

Vascul Pharmacol. 2015 Aug;71:79-83. doi: 10.1016/j.vph.2014.12.006. Epub 2015 Apr 11.


Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.

Kavian N, Mehlal S, Marut W, Servettaz A, Giessner C, Bourges C, Nicco C, Chéreau C, Lemaréchal H, Dutilh MF, Cerles O, Guilpain P, Vuiblet V, Chouzenoux S, Galland F, Quere I, Weill B, Naquet P, Batteux F.

J Immunol. 2016 Oct 15;197(8):3326-3335. Epub 2016 Sep 19.


Leflunomide prevents ROS-induced systemic fibrosis in mice.

Morin F, Kavian N, Chouzenoux S, Cerles O, Nicco C, Chéreau C, Batteux F.

Free Radic Biol Med. 2017 Jul;108:192-203. doi: 10.1016/j.freeradbiomed.2017.03.035. Epub 2017 Mar 30.


The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor β and contributes to the development of experimental dermal fibrosis.

Avouac J, Palumbo-Zerr K, Ruzehaji N, Tomcik M, Zerr P, Dees C, Distler A, Beyer C, Schneider H, Distler O, Schett G, Allanore Y, Distler JH.

Arthritis Rheumatol. 2014 Nov;66(11):3140-50. doi: 10.1002/art.38819.

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