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Items: 1 to 20 of 290

1.

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.

McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I.

Mol Cell. 2015 Jan 8;57(1):39-54. doi: 10.1016/j.molcel.2014.11.006. Epub 2014 Dec 11.

2.

PLEKHM1: Adapting to life at the lysosome.

McEwan DG, Dikic I.

Autophagy. 2015 Apr 3;11(4):720-2. doi: 10.1080/15548627.2015.1034419.

3.

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

Marwaha R, Arya SB, Jagga D, Kaur H, Tuli A, Sharma M.

J Cell Biol. 2017 Apr 3;216(4):1051-1070. doi: 10.1083/jcb.201607085. Epub 2017 Mar 21.

4.

PLEKHM1: a multiprotein adaptor for the endolysosomal system.

Rawet-Slobodkin M, Elazar Z.

Mol Cell. 2015 Jan 8;57(1):1-3. doi: 10.1016/j.molcel.2014.12.022.

5.

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I.

Mol Cell Biol. 2012 May;32(9):1733-44. doi: 10.1128/MCB.06717-11. Epub 2012 Feb 21.

6.

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes.

Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, Zhang G, Chen Y, Feng D, Hu J, Zhang H.

Mol Cell. 2016 Sep 1;63(5):781-95. doi: 10.1016/j.molcel.2016.08.021.

7.

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

Nguyen TN, Padman BS, Usher J, Oorschot V, Ramm G, Lazarou M.

J Cell Biol. 2016 Dec 19;215(6):857-874. Epub 2016 Nov 18.

8.

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N.

Mol Biol Cell. 2014 Apr;25(8):1327-37. doi: 10.1091/mbc.E13-08-0447. Epub 2014 Feb 19.

9.

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J.

Nat Commun. 2016 Jun 10;7:11808. doi: 10.1038/ncomms11808.

10.

Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.

Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T.

Mol Biol Cell. 2010 Dec;21(23):4162-72. doi: 10.1091/mbc.E10-06-0495. Epub 2010 Oct 13.

11.

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila.

Takáts S, Pircs K, Nagy P, Varga Á, Kárpáti M, Hegedűs K, Kramer H, Kovács AL, Sass M, Juhász G.

Mol Biol Cell. 2014 Apr;25(8):1338-54. doi: 10.1091/mbc.E13-08-0449. Epub 2014 Feb 19.

12.

Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.

Amaya C, Militello RD, Calligaris SD, Colombo MI.

Traffic. 2016 Nov;17(11):1181-1196. doi: 10.1111/tra.12431. Epub 2016 Oct 3.

13.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27. Erratum in: EMBO Rep. 2018 Dec;19(12):.

14.

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU.

Nat Cell Biol. 2008 Jul;10(7):776-87. doi: 10.1038/ncb1740. Epub 2008 Jun 15.

15.

Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.

Lee YK, Jun YW, Choi HE, Huh YH, Kaang BK, Jang DJ, Lee JA.

EMBO J. 2017 Apr 13;36(8):1100-1116. doi: 10.15252/embj.201696315. Epub 2017 Mar 20.

16.

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

Wartosch L, Günesdogan U, Graham SC, Luzio JP.

Traffic. 2015 Jul;16(7):727-42. doi: 10.1111/tra.12283. Epub 2015 Apr 30.

17.

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion.

Wang H, Sun HQ, Zhu X, Zhang L, Albanesi J, Levine B, Yin H.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7015-20. doi: 10.1073/pnas.1507263112. Epub 2015 May 18.

18.

Early endosomes and endosomal coatomer are required for autophagy.

Razi M, Chan EY, Tooze SA.

J Cell Biol. 2009 Apr 20;185(2):305-21. doi: 10.1083/jcb.200810098. Epub 2009 Apr 13.

19.

Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant.

Jenzer C, Manil-Ségalen M, Lefebvre C, Largeau C, Glatigny A, Legouis R.

Autophagy. 2014 Oct 1;10(10):1868-72. doi: 10.4161/auto.29745. Epub 2014 Jul 23.

20.

Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.

Zhen Y, Li W.

Autophagy. 2015;11(9):1608-22. doi: 10.1080/15548627.2015.1072669.

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