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Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J.

Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.


The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15.


Chaperone-assisted selective autophagy is essential for muscle maintenance.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J.

Curr Biol. 2010 Jan 26;20(2):143-8. doi: 10.1016/j.cub.2009.11.022. Epub 2010 Jan 7.


Tension-induced autophagy: may the chaperone be with you.

Ulbricht A, Höhfeld J.

Autophagy. 2013 Jun 1;9(6):920-2. doi: 10.4161/auto.24213. Epub 2013 Mar 21.


Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells.

Ulbricht A, Arndt V, Höhfeld J.

Commun Integr Biol. 2013 Jul 1;6(4):e24925. doi: 10.4161/cib.24925. Epub 2013 Jun 11.


Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.

Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J.

Autophagy. 2015;11(3):538-46. doi: 10.1080/15548627.2015.1017186.


BAG3 and friends: co-chaperones in selective autophagy during aging and disease.

Behl C.

Autophagy. 2011 Jul;7(7):795-8. doi: 10.4161/auto.7.7.15844.


HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.

Carra S, Seguin SJ, Landry J.

Autophagy. 2008 Feb;4(2):237-9. Epub 2007 Dec 11. Review.


Transcriptional upregulation of Bag3, a chaperone-assisted selective autophagy factor, in animal models of KY-deficient hereditary myopathy.

Jokl EJ, Hughes GL, Cracknell T, Pownall ME, Blanco G.

Dis Model Mech. 2018 Jul 6;11(7). pii: dmm033225. doi: 10.1242/dmm.033225.


WW domain of BAG3 is required for the induction of autophagy in glioma cells.

Merabova N, Sariyer IK, Saribas AS, Knezevic T, Gordon J, Turco MC, Rosati A, Weaver M, Landry J, Khalili K.

J Cell Physiol. 2015 Apr;230(4):831-41. doi: 10.1002/jcp.24811.


Chaperone-assisted selective autophagy in healthy and papillomavirus-associated neoplastic urothelium of cattle.

Roperto S, Russo V, Rosati A, Ceccarelli DM, Munday JS, Turco MC, Roperto F.

Vet Microbiol. 2018 Jul;221:134-142. doi: 10.1016/j.vetmic.2018.06.013. Epub 2018 Jun 18.


A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

Fuchs M, Luthold C, Guilbert SM, Varlet AA, Lambert H, Jetté A, Elowe S, Landry J, Lavoie JN.

PLoS Genet. 2015 Oct 23;11(10):e1005582. doi: 10.1371/journal.pgen.1005582. eCollection 2015 Oct.


BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.

Hishiya A, Kitazawa T, Takayama S.

Circ Res. 2010 Nov 12;107(10):1220-31. doi: 10.1161/CIRCRESAHA.110.225649. Epub 2010 Sep 30.


HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

Carra S, Seguin SJ, Lambert H, Landry J.

J Biol Chem. 2008 Jan 18;283(3):1437-44. Epub 2007 Nov 15.


Cardioprotection of exercise preconditioning involving heat shock protein 70 and concurrent autophagy: a potential chaperone-assisted selective macroautophagy effect.

Yuan Y, Pan SS, Shen YJ.

J Physiol Sci. 2018 Jan;68(1):55-67. doi: 10.1007/s12576-016-0507-7. Epub 2016 Dec 7.


Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division.

Varlet AA, Fuchs M, Luthold C, Lambert H, Landry J, Lavoie JN.

Cell Stress Chaperones. 2017 Jul;22(4):553-567. doi: 10.1007/s12192-017-0780-2. Epub 2017 Mar 8.


HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation.

Carra S, Brunsting JF, Lambert H, Landry J, Kampinga HH.

J Biol Chem. 2009 Feb 27;284(9):5523-32. doi: 10.1074/jbc.M807440200. Epub 2008 Dec 29.


Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.

Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C.

EMBO J. 2009 Apr 8;28(7):889-901. doi: 10.1038/emboj.2009.29. Epub 2009 Feb 19.


BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

Minoia M, Boncoraglio A, Vinet J, Morelli FF, Brunsting JF, Poletti A, Krom S, Reits E, Kampinga HH, Carra S.

Autophagy. 2014 Sep;10(9):1603-21. doi: 10.4161/auto.29409. Epub 2014 Jul 10.

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