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Items: 1 to 20 of 76


The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

Dhagat U, Hercus TR, Broughton SE, Nero TL, Cheung Tung Shing KS, Barry EF, Thomson CA, Bryson S, Pai EF, McClure BJ, Schrader JW, Lopez AF, Parker MW.

MAbs. 2018 Oct;10(7):1018-1029. doi: 10.1080/19420862.2018.1494107. Epub 2018 Sep 12.


Multispecificity of a recombinant anti-ras monoclonal antibody.

Schrader JW, McLean GR.

J Mol Recognit. 2018 Feb;31(2). doi: 10.1002/jmr.2683. Epub 2017 Nov 8.


Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.

Bryson S, Thomson CA, Risnes LF, Dasgupta S, Smith K, Schrader JW, Pai EF.

J Immunol. 2016 Jun 1;196(11):4723-30. doi: 10.4049/jimmunol.1402890. Epub 2016 Apr 29.


Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.

Ehrhardt A, Wang B, Yung AC, Wang Y, Kozlowski P, van Breemen C, Schrader JW.

PLoS One. 2015 Oct 30;10(10):e0141493. doi: 10.1371/journal.pone.0141493. eCollection 2015.


Absence of M-Ras modulates social behavior in mice.

Ehrhardt A, Wang B, Leung MJ, Schrader JW.

BMC Neurosci. 2015 Oct 21;16:68. doi: 10.1186/s12868-015-0209-8.


Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.

Wang Y, Thomson CA, Allan LL, Jackson LM, Olson M, Hercus TR, Nero TL, Turner A, Parker MW, Lopez AL, Waddell TK, Anderson GP, Hamilton JA, Schrader JW.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7832-7. doi: 10.1073/pnas.1216011110. Epub 2013 Apr 25.


A simplified method for the efficient refolding and purification of recombinant human GM-CSF.

Thomson CA, Olson M, Jackson LM, Schrader JW.

PLoS One. 2012;7(11):e49891. doi: 10.1371/journal.pone.0049891. Epub 2012 Nov 14.


Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem.

Thomson CA, Wang Y, Jackson LM, Olson M, Wang W, Liavonchanka A, Keleta L, Silva V, Diederich S, Jones RB, Gubbay J, Pasick J, Petric M, Jean F, Allen VG, Brown EG, Rini JM, Schrader JW.

Front Immunol. 2012 May 8;3:87. doi: 10.3389/fimmu.2012.00087. eCollection 2012.


Somatic diversity in CDR3 loops allows single V-genes to encode innate immunological memories for multiple pathogens.

Thomson CA, Little KQ, Reason DC, Schrader JW.

J Immunol. 2011 Feb 15;186(4):2291-8. doi: 10.4049/jimmunol.0904092. Epub 2011 Jan 12.


Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.

Thomson CA, Bryson S, McLean GR, Creagh AL, Pai EF, Schrader JW.

EMBO J. 2008 Oct 8;27(19):2592-602. doi: 10.1038/emboj.2008.179. Epub 2008 Sep 4.


RIVETS: the recombinant immunoglobulin and viral epitope tag system.

McLean GR, Cho CW, Trotter B, Schrader JW.

J Immunol Methods. 2006 Aug 31;315(1-2):208-13. Epub 2006 Aug 2.


Autoreactivity of primary human immunoglobulins ancestral to hypermutated human antibodies that neutralize HCMV.

McLean GR, Cho CW, Schrader JW.

Mol Immunol. 2006 May;43(12):2012-22. Epub 2006 Jan 19.


Absence of caprin-1 results in defects in cellular proliferation.

Wang B, David MD, Schrader JW.

J Immunol. 2005 Oct 1;175(7):4274-82.


A point mutation in the Ch3 domain of human IgG3 inhibits antibody secretion without affecting antigen specificity.

McLean GR, Torres M, Trotter B, Noseda M, Bryson S, Pai EF, Schrader JW, Casadevall A.

Mol Immunol. 2005 May;42(9):1111-9. Epub 2005 Jan 4.


Recognition of human cytomegalovirus by human primary immunoglobulins identifies an innate foundation to an adaptive immune response.

McLean GR, Olsen OA, Watt IN, Rathanaswami P, Leslie KB, Babcook JS, Schrader JW.

J Immunol. 2005 Apr 15;174(8):4768-78.


Biased immunoglobulin G (IgG) subclass production in a case of hyper-IgM syndrome.

McLean GR, Miller KK, Schrader JW, Junker AK.

Clin Diagn Lab Immunol. 2004 Nov;11(6):1192-3.

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