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Items: 1 to 20 of 157


Terminal uridylyltransferases target RNA viruses as part of the innate immune system.

Le Pen J, Jiang H, Di Domenico T, Kneuss E, Kosałka J, Leung C, Morgan M, Much C, Rudolph KLM, Enright AJ, O'Carroll D, Wang D, Miska EA.

Nat Struct Mol Biol. 2018 Sep;25(9):778-786. doi: 10.1038/s41594-018-0106-9. Epub 2018 Aug 13.


Cellular and epigenetic drivers of stem cell ageing.

Ermolaeva M, Neri F, Ori A, Rudolph KL.

Nat Rev Mol Cell Biol. 2018 Sep;19(9):594-610. doi: 10.1038/s41580-018-0020-3. Review.


Telomeres in cancer.

Gunes C, Avila AI, Rudolph KL.

Differentiation. 2018 Jan - Feb;99:41-50. doi: 10.1016/j.diff.2017.12.004. Epub 2017 Dec 21. Review.


Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.

Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL.

Leukemia. 2017 Dec;31(12):2853. doi: 10.1038/leu.2017.224. Epub 2017 Nov 10.


Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, Fagagna FDD, Günes C, Rudolph KL.

EMBO J. 2017 Oct 2;36(19):2922-2924. doi: 10.15252/embj.201797470. No abstract available.


Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.

Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M, Rudolph KL.

EMBO J. 2017 Oct 2;36(19):2920-2921. doi: 10.15252/embj.201797813. No abstract available.


The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.

Akay A, Di Domenico T, Suen KM, Nabih A, Parada GE, Larance M, Medhi R, Berkyurek AC, Zhang X, Wedeles CJ, Rudolph KLM, Engelhardt J, Hemberg M, Ma P, Lamond AI, Claycomb JM, Miska EA.

Dev Cell. 2017 Aug 7;42(3):241-255.e6. doi: 10.1016/j.devcel.2017.07.002.


The Profile and Dynamics of RNA Modifications in Animals.

van Delft P, Akay A, Huber SM, Bueschl C, Rudolph KLM, Di Domenico T, Schuhmacher R, Miska EA, Balasubramanian S.

Chembiochem. 2017 Jun 1;18(11):979-984. doi: 10.1002/cbic.201700093. Epub 2017 Apr 27.


The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P.

PLoS One. 2017 Feb 15;12(2):e0166875. doi: 10.1371/journal.pone.0166875. eCollection 2017.


Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.

Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J, Tümpel S, Rudolph KL.

Nature. 2016 Dec 15;540(7633):428-432. doi: 10.1038/nature20603. Epub 2016 Nov 30.


Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.

Scheffold A, Holtman IR, Dieni S, Brouwer N, Katz SF, Jebaraj BM, Kahle PJ, Hengerer B, Lechel A, Stilgenbauer S, Boddeke EW, Eggen BJ, Rudolph KL, Biber K.

Acta Neuropathol Commun. 2016 Aug 22;4(1):87. doi: 10.1186/s40478-016-0364-x.


p21 shapes cancer evolution.

Romanov VS, Rudolph KL.

Nat Cell Biol. 2016 Jun 28;18(7):722-4. doi: 10.1038/ncb3382.


Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.

Rudolph KL, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT.

PLoS Genet. 2016 May 11;12(5):e1006024. doi: 10.1371/journal.pgen.1006024. eCollection 2016 May.


Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.

Wang J, Morita Y, Han B, Niemann S, Löffler B, Rudolph KL.

Nat Cell Biol. 2016 May;18(5):480-90. doi: 10.1038/ncb3342. Epub 2016 Apr 18.


SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.

Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z.

Cell Stem Cell. 2016 Apr 7;18(4):495-507. doi: 10.1016/j.stem.2016.03.005.


Telomere shortening leads to earlier age of onset in ALS mice.

Linkus B, Wiesner D, Meßner M, Karabatsiakis A, Scheffold A, Rudolph KL, Thal DR, Weishaupt JH, Ludolph AC, Danzer KM.

Aging (Albany NY). 2016 Feb;8(2):382-93.


Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.

Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL.

J Exp Med. 2016 Apr 4;213(4):535-53. doi: 10.1084/jem.20151100. Epub 2016 Mar 7.


Identification of ageing-associated naturally occurring peptides in human urine.

Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H.

Oncotarget. 2015 Oct 27;6(33):34106-17. doi: 10.18632/oncotarget.5896.


Telomere Dysfunction, Chromosomal Instability and Cancer.

Meena J, Rudolph KL, Günes C.

Recent Results Cancer Res. 2015;200:61-79. doi: 10.1007/978-3-319-20291-4_3. Review.


Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo.

Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig A, Bauer M, Traeger A, Schubert US.

J Control Release. 2015 Oct 28;216:158-68. doi: 10.1016/j.jconrel.2015.08.008. Epub 2015 Aug 12.


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