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Items: 1 to 20 of 261

1.

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.

Yoo YD, Mun SR, Ji CH, Sung KW, Kang KY, Heo AJ, Lee SH, An JY, Hwang J, Xie XQ, Ciechanover A, Kim BY, Kwon YT.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2716-E2724. doi: 10.1073/pnas.1719110115. Epub 2018 Mar 5.

PMID:
29507222
2.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

3.

The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.

Shim SM, Choi HR, Sung KW, Lee YJ, Kim ST, Kim D, Mun SR, Hwang J, Cha-Molstad H, Ciechanover A, Kim BY, Kwon YT.

Sci Signal. 2018 Jan 2;11(511). pii: eaan0630. doi: 10.1126/scisignal.aan0630.

PMID:
29295953
4.

Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway.

Cha-Molstad H, Lee SH, Kim JG, Sung KW, Hwang J, Shim SM, Ganipisetti S, McGuire T, Mook-Jung I, Ciechanover A, Xie XQ, Kim BY, Kwon YT.

Autophagy. 2018;14(2):359-361. doi: 10.1080/15548627.2017.1415190. Epub 2018 Jan 29.

PMID:
29261001
5.

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

Ciechanover A.

Best Pract Res Clin Haematol. 2017 Dec;30(4):341-355. doi: 10.1016/j.beha.2017.09.001. Epub 2017 Sep 22. Review.

PMID:
29156207
6.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

7.

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.

Kwon YT, Ciechanover A.

Trends Biochem Sci. 2017 Nov;42(11):873-886. doi: 10.1016/j.tibs.2017.09.002. Epub 2017 Sep 22. Review.

PMID:
28947091
8.

Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

Yoo YD, Lee DH, Cha-Molstad H, Kim H, Mun SR, Ji C, Park SH, Sung KS, Choi SA, Hwang J, Park DM, Kim SK, Park KJ, Kang SH, Oh SC, Ciechanover A, Lee YJ, Kim BY, Kwon YT.

EMBO Rep. 2017 Sep;18(9):1671. doi: 10.15252/embr.201744761. No abstract available.

9.

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY.

Nat Commun. 2017 Jul 24;8(1):102. doi: 10.1038/s41467-017-00085-7.

10.

Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal.

Livneh I, Kravtsova-Ivantsiv Y, Braten O, Kwon YT, Ciechanover A.

Bioessays. 2017 Jun;39(6). doi: 10.1002/bies.201700027. Epub 2017 May 11. Review.

PMID:
28493408
11.

Protein Quality Control by Molecular Chaperones in Neurodegeneration.

Ciechanover A, Kwon YT.

Front Neurosci. 2017 Apr 6;11:185. doi: 10.3389/fnins.2017.00185. eCollection 2017. Review.

12.

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.

Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu S, Nelson N, Kravtsova-Ivantsiv Y, Mills GB, Davies MA, Hoon DSB.

Clin Cancer Res. 2017 Aug 15;23(16):4831-4842. doi: 10.1158/1078-0432.CCR-17-0146. Epub 2017 Apr 7.

PMID:
28389511
13.

The ubiquitin-proteasome system: A potential therapeutic target for heart failure.

Barac YD, Emrich F, Krutzwakd-Josefson E, Schrepfer S, Sampaio LC, Willerson JT, Robbins RC, Ciechanover A, Mohr FW, Aravot D, Taylor DA.

J Heart Lung Transplant. 2017 Jul;36(7):708-714. doi: 10.1016/j.healun.2017.02.012. Epub 2017 Feb 20. Review.

PMID:
28341100
14.

Immune defects caused by mutations in the ubiquitin system.

Etzioni A, Ciechanover A, Pikarsky E.

J Allergy Clin Immunol. 2017 Mar;139(3):743-753. doi: 10.1016/j.jaci.2016.11.031. Review.

PMID:
28270366
15.

Stress-induced polyubiquitination of proteasomal ubiquitin receptors targets the proteolytic complex for autophagic degradation.

Cohen-Kaplan V, Ciechanover A, Livneh I.

Autophagy. 2017 Apr 3;13(4):759-760. doi: 10.1080/15548627.2016.1278327. Epub 2017 Jan 25.

16.

Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria.

Lehmann G, Udasin RG, Livneh I, Ciechanover A.

Biochem Biophys Res Commun. 2017 Feb 12;483(3):946-950. doi: 10.1016/j.bbrc.2017.01.037. Epub 2017 Jan 10.

PMID:
28087277
17.

Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

Yoo YD, Lee DH, Cha-Molstad H, Kim H, Mun SR, Ji C, Park SH, Sung KS, Choi SA, Hwang J, Park DM, Kim SK, Park KJ, Kang SH, Oh SC, Ciechanover A, Lee YJ, Kim BY, Kwon YT.

EMBO Rep. 2017 Jan;18(1):150-168. doi: 10.15252/embr.201642360. Epub 2016 Dec 19. Erratum in: EMBO Rep. 2017 Sep;18(9):1671.

18.

p62 at the crossroad of the ubiquitin-proteasome system and autophagy.

Cohen-Kaplan V, Ciechanover A, Livneh I.

Oncotarget. 2016 Dec 20;7(51):83833-83834. doi: 10.18632/oncotarget.13805. No abstract available.

19.

The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2.

Lahav-Baratz S, Kravtsova-Ivantsiv Y, Golan S, Ciechanover A.

Biochem Biophys Res Commun. 2017 Jan 1;482(1):106-111. doi: 10.1016/j.bbrc.2016.10.135. Epub 2016 Oct 31.

PMID:
27810359
20.

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

Cohen-Kaplan V, Livneh I, Avni N, Fabre B, Ziv T, Kwon YT, Ciechanover A.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7490-E7499. Epub 2016 Oct 17.

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