Format

Send to

Choose Destination
Sci China C Life Sci. 2009 Jun;52(6):501-5. doi: 10.1007/s11427-009-0074-8. Epub 2009 Jun 26.

Glutathione exhibits antibacterial activity and increases tetracycline efficacy against Pseudomonas aeruginosa.

Author information

1
Molecular Microbiology Laboratory, the College of Life Sciences, Northwest University, Xi'an 710069, China.

Abstract

Glutathione (GSH) plays important roles in pulmonary diseases, and inhaled GSH therapy has been used to treat cystic fibrosis (CF) patients in clinical trials. The results in this report revealed that GSH altered the sensitivity of Pseudomonas aeruginosa to different antibiotics through pathways unrelated to the oxidative stress as generally perceived. In addition, GSH and its oxidized form inhibited the growth of P. aeruginosa.

PMID:
19557326
DOI:
10.1007/s11427-009-0074-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center