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Vertex. 2006 May-Jun;17(67):165-71.

[The relationship between the Wnt signaling and the psychiatric diseases].

[Article in Spanish]

Author information

1
Instituto de Investigaci├│n farmacol├│gico, Conicet, Argentina. aferrero@ffyb.uba.ar

Abstract

It has been demonstrated that the neuronal plasticity and resilience could participate in the pathophysiology of neurodegenerative diseases such as Alzheimer and others like depression and schizophrenia. Recently, it has been proposed a new intracellular pathway, known as Wnt pathway, which could be related to the induction of the plastic changes mentioned above. The glycogen synthase kinase-3beta (GSK-3beta), one of the main enzymes of the Wnt signaling, has been associated to Alzheimer;s and schizophrenia diseases etiology. Furthermore, the mood stabilizing agents;s action mechanism, like lithium and valproic acid, implies the inhibition of this protein. The issue of this work is to describe the proteins that are recruited when this pathway is activated and the GSK-3beta role in the pathologies mentioned.

PMID:
16847474
[Indexed for MEDLINE]

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