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Items: 1 to 20 of 62


Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?

Asaro RJ, Zhu Q, Cabrales P, Carruthers A.

Biophys J. 2018 Mar 27;114(6):1440-1454. doi: 10.1016/j.bpj.2018.01.041.


Kinetic Basis of Cis- and Trans-Allostery in GLUT1-Mediated Sugar Transport.

Lloyd KP, Ojelabi OA, Simon AH, De Zutter JK, Carruthers A.

J Membr Biol. 2018 Feb;251(1):131-152. doi: 10.1007/s00232-017-0006-7. Epub 2017 Dec 5.


Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters.

Lloyd KP, Ojelabi OA, De Zutter JK, Carruthers A.

J Biol Chem. 2017 Dec 22;292(51):21035-21046. doi: 10.1074/jbc.M117.815589. Epub 2017 Oct 24.


WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site.

Ojelabi OA, Lloyd KP, Simon AH, De Zutter JK, Carruthers A.

J Biol Chem. 2016 Dec 23;291(52):26762-26772. doi: 10.1074/jbc.M116.759175. Epub 2016 Nov 11.


Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.

Sage JM, Cura AJ, Lloyd KP, Carruthers A.

Am J Physiol Cell Physiol. 2015 May 15;308(10):C827-34. doi: 10.1152/ajpcell.00001.2015. Epub 2015 Feb 25.


A novel model for brain iron uptake: introducing the concept of regulation.

Simpson IA, Ponnuru P, Klinger ME, Myers RL, Devraj K, Coe CL, Lubach GR, Carruthers A, Connor JR.

J Cereb Blood Flow Metab. 2015 Jan;35(1):48-57. doi: 10.1038/jcbfm.2014.168. Epub 2014 Oct 15.


Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex.

Sage JM, Carruthers A.

Am J Physiol Cell Physiol. 2014 May 15;306(10):C910-7. doi: 10.1152/ajpcell.00044.2014. Epub 2014 Mar 5.


Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis.

De Zutter JK, Levine KB, Deng D, Carruthers A.

J Biol Chem. 2013 Jul 12;288(28):20734-44. doi: 10.1074/jbc.M113.469023. Epub 2013 May 29.


Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesis.

Vollers SS, Carruthers A.

J Biol Chem. 2012 Dec 14;287(51):42533-44. doi: 10.1074/jbc.M112.369587. Epub 2012 Oct 23.


AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress.

Cura AJ, Carruthers A.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C806-14. doi: 10.1152/ajpcell.00437.2011. Epub 2012 Jul 3.


Response to 'comment on recent modeling studies of astrocyte-neuron metabolic interactions': much ado about nothing.

Mangia S, DiNuzzo M, Giove F, Carruthers A, Simpson IA, Vannucci SJ.

J Cereb Blood Flow Metab. 2011 Jun;31(6):1346-53. doi: 10.1038/jcbfm.2011.29. Epub 2011 Mar 23. Review.


Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial site.

Robichaud T, Appleyard AN, Herbert RB, Henderson PJ, Carruthers A.

Biochemistry. 2011 Apr 19;50(15):3137-48. doi: 10.1021/bi1020327. Epub 2011 Mar 25.


Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway.

Cura AJ, Carruthers A.

J Biol Chem. 2010 May 14;285(20):15430-9. doi: 10.1074/jbc.M110.110593. Epub 2010 Mar 15.


Will the original glucose transporter isoform please stand up!

Carruthers A, DeZutter J, Ganguly A, Devaskar SU.

Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E836-48. doi: 10.1152/ajpendo.00496.2009. Epub 2009 Aug 18. Review.


The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation.

Mangia S, Simpson IA, Vannucci SJ, Carruthers A.

J Neurochem. 2009 May;109 Suppl 1:55-62. doi: 10.1111/j.1471-4159.2009.06003.x.


alpha- and beta-monosaccharide transport in human erythrocytes.

Leitch JM, Carruthers A.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C151-61. doi: 10.1152/ajpcell.00359.2008. Epub 2008 Nov 5.


Analysis of glucose transporter topology and structural dynamics.

Blodgett DM, Graybill C, Carruthers A.

J Biol Chem. 2008 Dec 26;283(52):36416-24. doi: 10.1074/jbc.M804802200. Epub 2008 Nov 3.


Structural basis of GLUT1 inhibition by cytoplasmic ATP.

Blodgett DM, De Zutter JK, Levine KB, Karim P, Carruthers A.

J Gen Physiol. 2007 Aug;130(2):157-68. Epub 2007 Jul 16.


Supply and demand in cerebral energy metabolism: the role of nutrient transporters.

Simpson IA, Carruthers A, Vannucci SJ.

J Cereb Blood Flow Metab. 2007 Nov;27(11):1766-91. Epub 2007 Jun 20. Review.

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