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Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs.

Dreier C, Resa-Infante P, Thiele S, Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Preuss A, Müller Z, Klenk HD, Stech J, Gabriel G.

Emerg Microbes Infect. 2019;8(1):1324-1336. doi: 10.1080/22221751.2019.1663131.


Double-attenuated influenza virus elicits broad protection against challenge viruses with different serotypes in swine.

Mamerow S, Scheffter R, Röhrs S, Stech O, Blohm U, Schwaiger T, Schröder C, Ulrich R, Schinköthe J, Beer M, Mettenleiter TC, Stech J.

Vet Microbiol. 2019 Apr;231:160-168. doi: 10.1016/j.vetmic.2019.03.013. Epub 2019 Mar 12.


A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle.

Martin S, Chiramel AI, Schmidt ML, Chen YC, Whitt N, Watt A, Dunham EC, Shifflett K, Traeger S, Leske A, Buehler E, Martellaro C, Brandt J, Wendt L, Müller A, Peitsch S, Best SM, Stech J, Finke S, Römer-Oberdörfer A, Groseth A, Feldmann H, Hoenen T.

Genome Med. 2018 Aug 7;10(1):58. doi: 10.1186/s13073-018-0570-1.


A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence.

Wessels U, Abdelwhab EM, Veits J, Hoffmann D, Mamerow S, Stech O, Hellert J, Beer M, Mettenleiter TC, Stech J.

J Virol. 2018 Aug 16;92(17). pii: e00778-18. doi: 10.1128/JVI.00778-18. Print 2018 Sep 1.


Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells.

Yang W, Lambertz RLO, Punyadarsaniya D, Leist SR, Stech J, Schughart K, Herrler G, Wu NH, Meng F.

Vet Microbiol. 2017 Nov;211:129-134. doi: 10.1016/j.vetmic.2017.10.015. Epub 2017 Oct 16.


Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.

Yang W, Punyadarsaniya D, Lambertz RLO, Lee DCC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F, Herrler G.

J Virol. 2017 Mar 29;91(8). pii: e02125-16. doi: 10.1128/JVI.02125-16. Print 2017 Apr 15.


Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift.

Abdelwhab EM, Veits J, Tauscher K, Ziller M, Grund C, Hassan MK, Shaheen M, Harder TC, Teifke J, Stech J, Mettenleiter TC.

J Gen Virol. 2016 Dec;97(12):3193-3204. doi: 10.1099/jgv.0.000648. Epub 2016 Oct 28.


Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens.

Abdelwhab el-SM, Veits J, Breithaupt A, Gohrbandt S, Ziller M, Teifke JP, Stech J, Mettenleiter TC.

Virulence. 2016 Jul 3;7(5):546-57. doi: 10.1080/21505594.2016.1159367. Epub 2016 Mar 16.


A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens.

Abdelwhab el-SM, Veits J, Tauscher K, Ziller M, Teifke JP, Stech J, Mettenleiter TC.

J Virol. 2015 Oct 21;90(1):400-11. doi: 10.1128/JVI.02082-15. Print 2016 Jan 1.


Pathogenicity evaluation of neuraminidase-negative H5 and H7 viruses in day-old chicks and adult chicken.

Hoffmann D, Röhrs S, Rahn J, Stech J, Beer M.

Vaccine. 2015 Dec 8;33(49):6997-7001. doi: 10.1016/j.vaccine.2015.09.106. Epub 2015 Oct 21.


Improved universal cloning of influenza A virus genes by LacZα-mediated blue/white selection.

Wessels U, Stech O, Abdelwhab el-SM, Judel A, Mettenleiter TC, Stech J.

J Virol Methods. 2015 Dec 1;225:87-9. doi: 10.1016/j.jviromet.2015.09.009. Epub 2015 Sep 25.


The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken.

Stech O, Veits J, Abdelwhab EM, Wessels U, Mettenleiter TC, Stech J.

Sci Rep. 2015 Aug 26;5:13493. doi: 10.1038/srep13493.


Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

Sauer AK, Liang CH, Stech J, Peeters B, Quéré P, Schwegmann-Wessels C, Wu CY, Wong CH, Herrler G.

PLoS One. 2014 Feb 21;9(2):e89529. doi: 10.1371/journal.pone.0089529. eCollection 2014.


Avian influenza virus h3 hemagglutinin may enable high fitness of novel human virus reassortants.

Kreibich A, Stech O, Hundt J, Ziller M, Mettenleiter TC, Stech J.

PLoS One. 2013 Nov 12;8(11):e79165. doi: 10.1371/journal.pone.0079165. eCollection 2013.


Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses.

Kalthoff D, Röhrs S, Höper D, Hoffmann B, Bogs J, Stech J, Beer M.

J Virol. 2013 Dec;87(24):13556-68. doi: 10.1128/JVI.02244-13. Epub 2013 Oct 9.


Can high-pathogenic avian influenza viruses with novel hemagglutinin serotypes other than H5 or H7 emerge?

Stech J, Mettenleiter TC.

Virulence. 2012 Jul 1;3(4):418-9. doi: 10.4161/viru.20974. Epub 2012 Jun 22. No abstract available.


Diversifying evolution of highly pathogenic H5N1 avian influenza virus in Egypt from 2006 to 2011.

Abdelwhab EM, Arafa AS, Stech J, Grund C, Stech O, Graeber-Gerberding M, Beer M, Hassan MK, Aly MM, Harder TC, Hafez HM.

Virus Genes. 2012 Aug;45(1):14-23. doi: 10.1007/s11262-012-0758-1. Epub 2012 Jun 5.


Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells.

Ocaña-Macchi M, Ricklin ME, Python S, Monika GA, Stech J, Stech O, Summerfield A.

Virology. 2012 May 25;427(1):1-9. doi: 10.1016/j.virol.2012.01.037. Epub 2012 Feb 23.


Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype.

Veits J, Weber S, Stech O, Breithaupt A, Gräber M, Gohrbandt S, Bogs J, Hundt J, Teifke JP, Mettenleiter TC, Stech J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2579-84. doi: 10.1073/pnas.1109397109. Epub 2012 Jan 30.


Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine.

Stech J, Garn H, Herwig A, Stech O, Dauber B, Wolff T, Mettenleiter TC, Klenk HD.

J Infect Dis. 2011 Nov 15;204(10):1483-90. doi: 10.1093/infdis/jir613. Epub 2011 Sep 14.


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