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Items: 1 to 50 of 62

1.

The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML.

Biomedicines. 2018 Mar 19;6(1). pii: E36. doi: 10.3390/biomedicines6010036. Review.

2.

COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JH, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B.

Circ Res. 2018 Mar 15. pii: CIRCRESAHA.117.312004. doi: 10.1161/CIRCRESAHA.117.312004. [Epub ahead of print]

PMID:
29545368
3.

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaam8574. doi: 10.1126/scitranslmed.aam8574.

PMID:
29118264
4.

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B.

Biochim Biophys Acta. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16.

PMID:
28723419
5.

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel.

Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano AL.

Eur Heart J. 2017 Aug 21;38(32):2459-2472. doi: 10.1093/eurheartj/ehx144.

6.

News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.

van de Sluis B, Wijers M, Herz J.

Curr Opin Lipidol. 2017 Jun;28(3):241-247. doi: 10.1097/MOL.0000000000000411. Review.

7.

A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis.

Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J.

Hepatology. 2017 Sep;66(3):794-808. doi: 10.1002/hep.29034. Epub 2017 Jul 18.

PMID:
28073183
8.

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.

Fedoseienko A, Wieringa HW, Wisman GB, Duiker E, Reyners AK, Hofker MH, van der Zee AG, van de Sluis B, van Vugt MA.

PLoS One. 2016 Oct 27;11(10):e0165385. doi: 10.1371/journal.pone.0165385. eCollection 2016.

9.

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Booij HG, Yu H, De Boer RA, van de Kolk CW, van de Sluis B, Van Deursen JM, Van Gilst WH, Silljé HH, Westenbrink BD.

Cardiovasc Res. 2016 Aug 1;111(3):217-26. doi: 10.1093/cvr/cvw161. Epub 2016 Jun 14.

PMID:
27302402
10.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MA, Kloosterhuis NJ, Melki R, van Cruchten RT, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TP, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 12. pii: S1097-2765(16)00227-6. doi: 10.1016/j.molcel.2016.03.017. [Epub ahead of print]

11.

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B.

Nat Commun. 2016 Mar 11;7:10961. doi: 10.1038/ncomms10961.

12.

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.

Fieten H, Gill Y, Martin AJ, Concilli M, Dirksen K, van Steenbeek FG, Spee B, van den Ingh TS, Martens EC, Festa P, Chesi G, van de Sluis B, Houwen RH, Watson AL, Aulchenko YS, Hodgkinson VL, Zhu S, Petris MJ, Polishchuk RS, Leegwater PA, Rothuizen J.

Dis Model Mech. 2016 Jan;9(1):25-38. doi: 10.1242/dmm.020263.

13.

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.

Chesi G, Hegde RN, Iacobacci S, Concilli M, Parashuraman S, Festa BP, Polishchuk EV, Di Tullio G, Carissimo A, Montefusco S, Canetti D, Monti M, Amoresano A, Pucci P, van de Sluis B, Lutsenko S, Luini A, Polishchuk RS.

Hepatology. 2016 Jun;63(6):1842-59. doi: 10.1002/hep.28398. Epub 2016 Jan 25.

14.

In-vivo genome editing using CRISPR-Cas9 to study lipid metabolism.

van de Sluis B.

Curr Opin Lipidol. 2016 Feb;27(1):92-3. doi: 10.1097/MOL.0000000000000264. No abstract available.

PMID:
26655294
15.

Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.

Pulskens WP, Verkaik M, Sheedfar F, van Loon EP, van de Sluis B, Vervloet MG, Hoenderop JG, Bindels RJ; NIGRAM Consortium.

PLoS One. 2015 Nov 13;10(11):e0142510. doi: 10.1371/journal.pone.0142510. eCollection 2015.

16.

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E.

J Cell Biol. 2015 Nov 9;211(3):605-17. doi: 10.1083/jcb.201505108.

17.

The NADPH oxidase Nox4 has anti-atherosclerotic functions.

Schürmann C, Rezende F, Kruse C, Yasar Y, Löwe O, Fork C, van de Sluis B, Bremer R, Weissmann N, Shah AM, Jo H, Brandes RP, Schröder K.

Eur Heart J. 2015 Dec 21;36(48):3447-56. doi: 10.1093/eurheartj/ehv460. Epub 2015 Sep 17.

18.

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.

Smeets CJ, Jezierska J, Watanabe H, Duarri A, Fokkens MR, Meijer M, Zhou Q, Yakovleva T, Boddeke E, den Dunnen W, van Deursen J, Bakalkin G, Kampinga HH, van de Sluis B, Verbeek DS.

Brain. 2015 Sep;138(Pt 9):2537-52. doi: 10.1093/brain/awv195. Epub 2015 Jul 12.

PMID:
26169942
19.

Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice.

Gruben N, Funke A, Kloosterhuis NJ, Schreurs M, Sheedfar F, Havinga R, Houten SM, Shiri-Sverdlov R, van de Sluis B, Kuivenhoven JA, Koonen DP, Hofker MH.

J Diabetes Res. 2015;2015:956854. doi: 10.1155/2015/956854. Epub 2015 Feb 28.

20.

The life cycle of the low-density lipoprotein receptor: insights from cellular and in-vivo studies.

Wijers M, Kuivenhoven JA, van de Sluis B.

Curr Opin Lipidol. 2015 Apr;26(2):82-7. doi: 10.1097/MOL.0000000000000157. Review.

PMID:
25692346
21.

A cell-type-specific role for murine Commd1 in liver inflammation.

Bartuzi P, Wijshake T, Dekker DC, Fedoseienko A, Kloosterhuis NJ, Youssef SA, Li H, Shiri-Sverdlov R, Kuivenhoven JA, de Bruin A, Burstein E, Hofker MH, van de Sluis B.

Biochim Biophys Acta. 2014 Nov;1842(11):2257-65. doi: 10.1016/j.bbadis.2014.06.035. Epub 2014 Jul 27.

22.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.

23.

Endonucleases: new tools to edit the mouse genome.

Wijshake T, Baker DJ, van de Sluis B.

Biochim Biophys Acta. 2014 Oct;1842(10):1942-1950. doi: 10.1016/j.bbadis.2014.04.020. Epub 2014 Apr 30. Review.

24.

Chemokine-like receptor 1 deficiency does not affect the development of insulin resistance and nonalcoholic fatty liver disease in mice.

Gruben N, Aparicio Vergara M, Kloosterhuis NJ, van der Molen H, Stoelwinder S, Youssef S, de Bruin A, Delsing DJ, Kuivenhoven JA, van de Sluis B, Hofker MH, Koonen DP.

PLoS One. 2014 Apr 29;9(4):e96345. doi: 10.1371/journal.pone.0096345. eCollection 2014.

25.

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.

Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.

Gastroenterology. 2014 Jul;147(1):184-195.e3. doi: 10.1053/j.gastro.2014.04.007. Epub 2014 Apr 13.

26.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Fedoseienko A, Bartuzi P, van de Sluis B.

Ann N Y Acad Sci. 2014 May;1314:6-14. doi: 10.1111/nyas.12353. Epub 2014 Feb 12. Review.

PMID:
24697840
27.

The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner.

Vonk WI, Kakkar V, Bartuzi P, Jaarsma D, Berger R, Hofker MH, Klomp LW, Wijmenga C, Kampinga HH, van de Sluis B.

PLoS One. 2014 Apr 1;9(4):e92408. doi: 10.1371/journal.pone.0092408. eCollection 2014.

28.

Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor.

Mahmud H, Candido WM, van Genne L, Vreeswijk-Baudoin I, Yu H, van de Sluis B, van Deursen J, van Gilst WH, Silljé HH, de Boer RA.

PLoS One. 2014 Feb 25;9(2):e89929. doi: 10.1371/journal.pone.0089929. eCollection 2014.

29.

Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice.

Funke A, Schreurs M, Aparicio-Vergara M, Sheedfar F, Gruben N, Kloosterhuis NJ, Shiri-Sverdlov R, Groen AK, van de Sluis B, Hofker MH, Koonen DP.

Atherosclerosis. 2014 Feb;232(2):390-6. doi: 10.1016/j.atherosclerosis.2013.11.074. Epub 2013 Dec 18.

30.

Tuning NF-κB activity: a touch of COMMD proteins.

Bartuzi P, Hofker MH, van de Sluis B.

Biochim Biophys Acta. 2013 Dec;1832(12):2315-21. doi: 10.1016/j.bbadis.2013.09.014. Epub 2013 Sep 29. Review.

31.

News on the genetics of lipoprotein metabolism and cardiovascular disease.

van de Sluis B, Kuivenhoven JA.

Curr Opin Lipidol. 2013 Apr;24(2):185-6. doi: 10.1097/MOL.0b013e32835ec621. No abstract available.

PMID:
23481232
32.

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM.

PLoS Genet. 2012;8(12):e1003138. doi: 10.1371/journal.pgen.1003138. Epub 2012 Dec 27.

33.

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM.

Nat Cell Biol. 2013 Jan;15(1):96-102. doi: 10.1038/ncb2643. Epub 2012 Dec 16.

34.

Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model.

Aparicio-Vergara M, Hommelberg PP, Schreurs M, Gruben N, Stienstra R, Shiri-Sverdlov R, Kloosterhuis NJ, de Bruin A, van de Sluis B, Koonen DP, Hofker MH.

Hepatology. 2013 Feb;57(2):566-76. doi: 10.1002/hep.26046. Epub 2013 Jan 10.

PMID:
22941955
35.

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner.

Maleszewska M, Moonen JR, Huijkman N, van de Sluis B, Krenning G, Harmsen MC.

Immunobiology. 2013 Apr;218(4):443-54. doi: 10.1016/j.imbio.2012.05.026. Epub 2012 Jun 6.

PMID:
22739237
36.

Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation.

Vonk WI, Bartuzi P, de Bie P, Kloosterhuis N, Wichers CG, Berger R, Haywood S, Klomp LW, Wijmenga C, van de Sluis B.

PLoS One. 2011;6(12):e29183. doi: 10.1371/journal.pone.0029183. Epub 2011 Dec 22.

37.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM.

Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600.

38.

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.

Vonk WI, de Bie P, Wichers CG, van den Berghe PV, van der Plaats R, Berger R, Wijmenga C, Klomp LW, van de Sluis B.

Cell Mol Life Sci. 2012 Jan;69(1):149-63. doi: 10.1007/s00018-011-0743-1. Epub 2011 Jun 11.

39.

Transgene design.

van de Sluis B, Voncken JW.

Methods Mol Biol. 2011;693:89-101. doi: 10.1007/978-1-60761-974-1_6.

PMID:
21080276
40.

Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1.

Vonk WI, Wijmenga C, Berger R, van de Sluis B, Klomp LW.

J Biol Chem. 2010 Sep 10;285(37):28991-9000. doi: 10.1074/jbc.M110.101477. Epub 2010 Jul 1.

41.

COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.

van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E.

J Clin Invest. 2010 Jun;120(6):2119-30. doi: 10.1172/JCI40583. Epub 2010 May 10.

42.

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.

van de Sluis B, Groot AJ, Vermeulen J, van der Wall E, van Diest PJ, Wijmenga C, Klomp LW, Vooijs M.

PLoS One. 2009 Oct 5;4(10):e7332. doi: 10.1371/journal.pone.0007332.

43.

Nuclear-cytosolic transport of COMMD1 regulates NF-kappaB and HIF-1 activity.

Muller PA, van de Sluis B, Groot AJ, Verbeek D, Vonk WI, Maine GN, Burstein E, Wijmenga C, Vooijs M, Reits E, Klomp LW.

Traffic. 2009 May;10(5):514-27. doi: 10.1111/j.1600-0854.2009.00892.x. Epub 2009 Feb 11.

44.

Relevance of animal models for understanding mammalian copper homeostasis.

Vonk WI, Wijmenga C, van de Sluis B.

Am J Clin Nutr. 2008 Sep;88(3):840S-5S. Review.

PMID:
18779305
45.

Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.

de Bie P, van de Sluis B, Burstein E, van de Berghe PV, Muller P, Berger R, Gitlin JD, Wijmenga C, Klomp LW.

Gastroenterology. 2007 Oct;133(4):1316-26. Epub 2007 Jul 25.

46.

COMMD1: a novel protein involved in the proteolysis of proteins.

van de Sluis B, Groot AJ, Wijmenga C, Vooijs M, Klomp LW.

Cell Cycle. 2007 Sep 1;6(17):2091-8. Epub 2007 Jun 22.

PMID:
17786049
47.

Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.

van den Berghe PV, Folmer DE, Malingré HE, van Beurden E, Klomp AE, van de Sluis B, Merkx M, Berger R, Klomp LW.

Biochem J. 2007 Oct 1;407(1):49-59.

48.

Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.

van de Sluis B, Muller P, Duran K, Chen A, Groot AJ, Klomp LW, Liu PP, Wijmenga C.

Mol Cell Biol. 2007 Jun;27(11):4142-56. Epub 2007 Mar 19.

49.

Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes.

Muller P, van Bakel H, van de Sluis B, Holstege F, Wijmenga C, Klomp LW.

J Biol Inorg Chem. 2007 May;12(4):495-507. Epub 2007 Jan 9.

PMID:
17211630
50.

Characterization of COMMD protein-protein interactions in NF-kappaB signalling.

de Bie P, van de Sluis B, Burstein E, Duran KJ, Berger R, Duckett CS, Wijmenga C, Klomp LW.

Biochem J. 2006 Aug 15;398(1):63-71.

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