Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 47

1.

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression.

Hornsveld M, Smits LMM, Meerlo M, van Amersfoort M, Groot Koerkamp MJA, van Leenen D, Kloet DEA, Holstege FCP, Derksen PWB, Burgering BMT, Dansen TB.

Cancer Res. 2018 Feb 12. doi: 10.1158/0008-5472.CAN-17-2511. [Epub ahead of print]

PMID:
29440168
2.

Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation.

Teunissen M, Riemers FM, van Leenen D, Groot Koerkamp MJA, Meij BP, Alblas J, Penning LC, Miranda-Bedate A, Tryfonidou MA.

J Orthop Res. 2018 Jan;36(1):138-148. doi: 10.1002/jor.23647. Epub 2017 Aug 14.

3.

EBV MicroRNA BART16 Suppresses Type I IFN Signaling.

Hooykaas MJG, van Gent M, Soppe JA, Kruse E, Boer IGJ, van Leenen D, Groot Koerkamp MJA, Holstege FCP, Ressing ME, Wiertz EJHJ, Lebbink RJ.

J Immunol. 2017 May 15;198(10):4062-4073. doi: 10.4049/jimmunol.1501605. Epub 2017 Apr 17.

PMID:
28416598
4.

Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters.

de Jonge WJ, O'Duibhir E, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Kemmeren P, Holstege FC.

EMBO J. 2017 Feb 1;36(3):274-290. doi: 10.15252/embj.201695621. Epub 2016 Dec 15.

5.

An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF.

Koot YE, van Hooff SR, Boomsma CM, van Leenen D, Groot Koerkamp MJ, Goddijn M, Eijkemans MJ, Fauser BC, Holstege FC, Macklon NS.

Sci Rep. 2016 Jan 22;6:19411. doi: 10.1038/srep19411.

6.

A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.

Sameith K, Amini S, Groot Koerkamp MJ, van Leenen D, Brok M, Brabers N, Lijnzaad P, van Hooff SR, Benschop JJ, Lenstra TL, Apweiler E, van Wageningen S, Snel B, Holstege FC, Kemmeren P.

BMC Biol. 2015 Dec 23;13:112. doi: 10.1186/s12915-015-0222-5.

7.

FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).

Kloet DE, Polderman PE, Eijkelenboom A, Smits LM, van Triest MH, van den Berg MC, Groot Koerkamp MJ, van Leenen D, Lijnzaad P, Holstege FC, Burgering BM.

Biochem J. 2015 Jul 15;469(2):289-98. doi: 10.1042/BJ20140831. Epub 2015 May 20.

8.

Cell cycle population effects in perturbation studies.

O'Duibhir E, Lijnzaad P, Benschop JJ, Lenstra TL, van Leenen D, Groot Koerkamp MJ, Margaritis T, Brok MO, Kemmeren P, Holstege FC.

Mol Syst Biol. 2014 Jun 21;10:732. doi: 10.15252/msb.20145172.

9.

The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression.

Boerkamp KM, van Steenbeek FG, Penning LC, Groot Koerkamp MJ, van Leenen D, Vos-Loohuis M, Grinwis GC, Rutteman GR.

PLoS One. 2014 Jun 2;9(6):e98258. doi: 10.1371/journal.pone.0098258. eCollection 2014.

10.

Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.

Kemmeren P, Sameith K, van de Pasch LA, Benschop JJ, Lenstra TL, Margaritis T, O'Duibhir E, Apweiler E, van Wageningen S, Ko CW, van Heesch S, Kashani MM, Ampatziadis-Michailidis G, Brok MO, Brabers NA, Miles AJ, Bouwmeester D, van Hooff SR, van Bakel H, Sluiters E, Bakker LV, Snel B, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Holstege FC.

Cell. 2014 Apr 24;157(3):740-52. doi: 10.1016/j.cell.2014.02.054.

11.

The role of Ctk1 kinase in termination of small non-coding RNAs.

Lenstra TL, Tudek A, Clauder S, Xu Z, Pachis ST, van Leenen D, Kemmeren P, Steinmetz LM, Libri D, Holstege FC.

PLoS One. 2013 Dec 4;8(12):e80495. doi: 10.1371/journal.pone.0080495. eCollection 2013.

12.

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E.

Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656.

PMID:
24141283
13.

Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog.

Boerkamp KM, van der Kooij M, van Steenbeek FG, van Wolferen ME, Groot Koerkamp MJ, van Leenen D, Grinwis GC, Penning LC, Wiemer EA, Rutteman GR.

PLoS One. 2013 Aug 1;8(8):e71094. doi: 10.1371/journal.pone.0071094. Print 2013.

14.

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

van de Pasch LA, Miles AJ, Nijenhuis W, Brabers NA, van Leenen D, Lijnzaad P, Brown MK, Ouellet J, Barral Y, Kops GJ, Holstege FC.

PLoS One. 2013 Jun 13;8(6):e65628. doi: 10.1371/journal.pone.0065628. Print 2013.

15.

Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.

Outchkourov NS, Muiño JM, Kaufmann K, van Ijcken WF, Groot Koerkamp MJ, van Leenen D, de Graaf P, Holstege FC, Grosveld FG, Timmers HT.

Cell Rep. 2013 Apr 25;3(4):1071-9. doi: 10.1016/j.celrep.2013.02.030. Epub 2013 Mar 28.

16.

Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.

van Steenbeek FG, Spee B, Penning LC, Kummeling A, van Gils IH, Grinwis GC, Van Leenen D, Holstege FC, Vos-Loohuis M, Rothuizen J, Leegwater PA.

PLoS One. 2013;8(3):e57973. doi: 10.1371/journal.pone.0057973. Epub 2013 Mar 5.

17.

Aberrant gene expression in dogs with portosystemic shunts.

van Steenbeek FG, Van den Bossche L, Grinwis GC, Kummeling A, van Gils IH, Koerkamp MJ, van Leenen D, Holstege FC, Penning LC, Rothuizen J, Leegwater PA, Spee B.

PLoS One. 2013;8(2):e57662. doi: 10.1371/journal.pone.0057662. Epub 2013 Feb 25. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5cccaae3-f06c-413f-857e-46546e87fce1.

18.

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.

Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GC, Houweling M, Groot Koerkamp MJ, van Leenen D, Holstege FC, Hazewinkel HA, Creemers LB, Penning LC, Tryfonidou MA.

Arthritis Res Ther. 2013 Jan 29;15(1):R23. doi: 10.1186/ar4157.

19.

Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases.

Snoeren N, van Hooff SR, Adam R, van Hillegersberg R, Voest EE, Guettier C, van Diest PJ, Nijkamp MW, Brok MO, van Leenen D, Koerkamp MJ, Holstege FC, Rinkes IH.

PLoS One. 2012;7(11):e49442. doi: 10.1371/journal.pone.0049442. Epub 2012 Nov 21.

20.

Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription.

Margaritis T, Oreal V, Brabers N, Maestroni L, Vitaliano-Prunier A, Benschop JJ, van Hooff S, van Leenen D, Dargemont C, Géli V, Holstege FC.

PLoS Genet. 2012 Sep;8(9):e1002952. doi: 10.1371/journal.pgen.1002952. Epub 2012 Sep 20.

21.

Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis.

Apweiler E, Sameith K, Margaritis T, Brabers N, van de Pasch L, Bakker LV, van Leenen D, Holstege FC, Kemmeren P.

BMC Genomics. 2012 Jun 14;13:239. doi: 10.1186/1471-2164-13-239.

22.

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.

Jacobs FM, Veenvliet JV, Almirza WH, Hoekstra EJ, von Oerthel L, van der Linden AJ, Neijts R, Koerkamp MG, van Leenen D, Holstege FC, Burbach JP, Smidt MP.

Development. 2011 Dec;138(23):5213-22. doi: 10.1242/dev.071704.

23.

The specificity and topology of chromatin interaction pathways in yeast.

Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC.

Mol Cell. 2011 May 20;42(4):536-49. doi: 10.1016/j.molcel.2011.03.026.

24.

Functional overlap and regulatory links shape genetic interactions between signaling pathways.

van Wageningen S, Kemmeren P, Lijnzaad P, Margaritis T, Benschop JJ, de Castro IJ, van Leenen D, Groot Koerkamp MJ, Ko CW, Miles AJ, Brabers N, Brok MO, Lenstra TL, Fiedler D, Fokkens L, Aldecoa R, Apweiler E, Taliadouros V, Sameith K, van de Pasch LA, van Hooff SR, Bakker LV, Krogan NJ, Snel B, Holstege FC.

Cell. 2010 Dec 10;143(6):991-1004. doi: 10.1016/j.cell.2010.11.021.

25.

A consensus of core protein complex compositions for Saccharomyces cerevisiae.

Benschop JJ, Brabers N, van Leenen D, Bakker LV, van Deutekom HW, van Berkum NL, Apweiler E, Lijnzaad P, Holstege FC, Kemmeren P.

Mol Cell. 2010 Jun 25;38(6):916-28. doi: 10.1016/j.molcel.2010.06.002.

26.

Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system.

Reemers SS, van Leenen D, Koerkamp MJ, van Haarlem D, van de Haar P, van Eden W, Vervelde L.

Mol Immunol. 2010 May;47(9):1675-85. doi: 10.1016/j.molimm.2010.03.008. Epub 2010 Apr 10.

PMID:
20382427
27.

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.

Dansen TB, Smits LM, van Triest MH, de Keizer PL, van Leenen D, Koerkamp MG, Szypowska A, Meppelink A, Brenkman AB, Yodoi J, Holstege FC, Burgering BM.

Nat Chem Biol. 2009 Sep;5(9):664-72. doi: 10.1038/nchembio.194. Epub 2009 Aug 2.

PMID:
19648934
28.

Adaptable gene-specific dye bias correction for two-channel DNA microarrays.

Margaritis T, Lijnzaad P, van Leenen D, Bouwmeester D, Kemmeren P, van Hooff SR, Holstege FC.

Mol Syst Biol. 2009;5:266. doi: 10.1038/msb.2009.21. Epub 2009 Apr 28.

29.

cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype.

Rao NA, van Wolferen ME, van den Ham R, van Leenen D, Groot Koerkamp MJ, Holstege FC, Mol JA.

Anim Genet. 2008 Aug;39(4):333-45. doi: 10.1111/j.1365-2052.2008.01733.x. Epub 2008 May 6.

PMID:
18462483
30.

Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification.

van Bakel H, van Werven FJ, Radonjic M, Brok MO, van Leenen D, Holstege FC, Timmers HT.

Nucleic Acids Res. 2008 Mar;36(4):e21. doi: 10.1093/nar/gkm1144. Epub 2008 Jan 7.

31.

Dissection of a metastatic gene expression signature into distinct components.

Roepman P, de Koning E, van Leenen D, de Weger RA, Kummer JA, Slootweg PJ, Holstege FC.

Genome Biol. 2006;7(12):R117.

32.

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

van de Peppel J, Kettelarij N, van Bakel H, Kockelkorn TT, van Leenen D, Holstege FC.

Mol Cell. 2005 Aug 19;19(4):511-22.

33.

Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit.

Radonjic M, Andrau JC, Lijnzaad P, Kemmeren P, Kockelkorn TT, van Leenen D, van Berkum NL, Holstege FC.

Mol Cell. 2005 Apr 15;18(2):171-83.

34.

Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment.

Chon H, Gaillard CA, van der Meijden BB, Dijstelbloem HM, Kraaijenhagen RJ, van Leenen D, Holstege FC, Joles JA, Bluyssen HA, Koomans HA, Braam B.

Hypertension. 2004 May;43(5):947-51. Epub 2004 Mar 8.

35.

Twenty-two novel mutations in the lysosomal alpha-glucosidase gene (GAA) underscore the genotype-phenotype correlation in glycogen storage disease type II.

Hermans MM, van Leenen D, Kroos MA, Beesley CE, Van Der Ploeg AT, Sakuraba H, Wevers R, Kleijer W, Michelakakis H, Kirk EP, Fletcher J, Bosshard N, Basel-Vanagaite L, Besley G, Reuser AJ.

Hum Mutat. 2004 Jan;23(1):47-56.

PMID:
14695532
36.

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H, van Leenen D, Holstege FC, Brummelkamp TR, Agami R, Clevers H.

EMBO Rep. 2003 Jun;4(6):609-15.

37.

Monitoring global messenger RNA changes in externally controlled microarray experiments.

van de Peppel J, Kemmeren P, van Bakel H, Radonjic M, van Leenen D, Holstege FC.

EMBO Rep. 2003 Apr;4(4):387-93.

38.

A Low-Cost Computerized System to Monitor Running Performance and Circadian Rhythms of Twenty Mice Simultaneously.

Van Leenen D, Bijvoet AG, Visser P, Heuvelsland GF, Verkerk A, Van Der Horst GT, Reuser AJ.

Contemp Top Lab Anim Sci. 1999 Nov;38(6):29-32.

PMID:
12086444
39.

Significantly higher number of fetal cells in the maternal circulation of women with pre-eclampsia.

Jansen MW, Korver-Hakkennes K, van Leenen D, Visser W, in 't Veld PA, de Groot CJ, Wladimiroff JW.

Prenat Diagn. 2001 Dec;21(12):1022-6.

PMID:
11746158
40.

How useful is the in vitro expansion of fetal CD34+ progenitor cells from maternal blood samples for diagnostic purposes?

Jansen MW, Korver-Hakkennes K, van Leenen D, Brandenburg H, Wildschut HI, Wladimiroff JW, Ploemacher RE.

Prenat Diagn. 2000 Sep;20(9):725-31.

PMID:
11015701
41.

Pathological features of glycogen storage disease type II highlighted in the knockout mouse model.

Bijvoet AG, Van Hirtum H, Vermey M, Van Leenen D, Van Der Ploeg AT, Mooi WJ, Reuser AJ.

J Pathol. 1999 Nov;189(3):416-24.

PMID:
10547605
42.

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.

van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A.

Nature. 1999 Apr 15;398(6728):627-30.

PMID:
10217146
43.
44.

Mutation detection in glycogen storage-disease type II by RT-PCR and automated sequencing.

Hermans MM, van Leenen D, Kroos MA, Reuser AJ.

Biochem Biophys Res Commun. 1997 Dec 18;241(2):414-8.

PMID:
9425285
45.

[Warning: sedatives for pets, effect on their master].

van Leenen D, Meenhorst PL, Beijnen JH.

Tijdschr Diergeneeskd. 1994 Dec 15;119(24):768. Dutch. No abstract available.

PMID:
7801313
46.

Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia.

van der Poll T, Jansen J, van Leenen D, von der Möhlen M, Levi M, ten Cate H, Gallati H, ten Cate JW, van Deventer SJ.

J Infect Dis. 1993 Oct;168(4):955-60.

PMID:
8397270
47.

Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.

van Leenen D, van der Poll T, Levi M, ten Cate H, van Deventer SJ, Hack CE, Aarden LA, ten Cate JW.

J Immunol. 1993 Aug 15;151(4):2318-25.

PMID:
8345209

Supplemental Content

Loading ...
Support Center