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Items: 1 to 50 of 237

1.

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming.

van Dinther D, Veninga H, Iborra S, Borg EGF, Hoogterp L, Olesek K, Beijer MR, Schetters STT, Kalay H, Garcia-Vallejo JJ, Franken KL, Cham LB, Lang KS, van Kooyk Y, Sancho D, Crocker PR, den Haan JMM.

Cell Rep. 2018 Feb 6;22(6):1484-1495. doi: 10.1016/j.celrep.2018.01.021.

2.

Neuroinflammation: Microglia and T Cells Get Ready to Tango.

Schetters STT, Gomez-Nicola D, Garcia-Vallejo JJ, Van Kooyk Y.

Front Immunol. 2018 Jan 25;8:1905. doi: 10.3389/fimmu.2017.01905. eCollection 2017.

3.

The tumour glyco-code as a novel immune checkpoint for immunotherapy.

RodrÍguez E, Schetters STT, van Kooyk Y.

Nat Rev Immunol. 2018 Feb 5. doi: 10.1038/nri.2018.3. [Epub ahead of print] Review.

PMID:
29398707
4.

Using the glycan toolbox for pathogenic interventions and glycan immunotherapy.

Li RE, van Vliet SJ, van Kooyk Y.

Curr Opin Biotechnol. 2017 Nov 22;51:24-31. doi: 10.1016/j.copbio.2017.11.003. [Epub ahead of print] Review.

PMID:
29175707
5.

Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy.

Machado Y, Duinkerken S, Hoepflinger V, Mayr M, Korotchenko E, Kurtaj A, Pablos I, Steiner M, Stoecklinger A, Lübbers J, Schmid M, Ritter U, Scheiblhofer S, Ablinger M, Wally V, Hochmann S, Raninger AM, Strunk D, van Kooyk Y, Thalhamer J, Weiss R.

J Control Release. 2017 Nov 28;266:87-99. doi: 10.1016/j.jconrel.2017.09.020. Epub 2017 Sep 14.

PMID:
28919557
6.

Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines.

van Dinther D, Stolk DA, van de Ven R, van Kooyk Y, de Gruijl TD, den Haan JMM.

J Leukoc Biol. 2017 Oct;102(4):1017-1034. doi: 10.1189/jlb.5MR0217-059RR. Epub 2017 Jul 20. Review.

7.

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.

Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T.

Angiogenesis. 2017 Nov;20(4):533-546. doi: 10.1007/s10456-017-9565-6. Epub 2017 Jul 11.

8.

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy.

Rodríguez E, Kalay H, Noya V, Brossard N, Giacomini C, van Kooyk Y, García-Vallejo JJ, Freire T.

Sci Rep. 2017 Apr 24;7:46748. doi: 10.1038/srep46748.

9.

Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin.

Rodríguez E, Carasi P, Frigerio S, da Costa V, van Vliet S, Noya V, Brossard N, van Kooyk Y, García-Vallejo JJ, Freire T.

Front Immunol. 2017 Mar 15;8:264. doi: 10.3389/fimmu.2017.00264. eCollection 2017.

10.

Improved cancer specificity in PSA assay using Aleuria aurantia lectin coated Eu-nanoparticles for detection.

Kekki H, Peltola M, van Vliet S, Bangma C, van Kooyk Y, Pettersson K.

Clin Biochem. 2017 Jan;50(1-2):54-61. doi: 10.1016/j.clinbiochem.2016.06.015. Epub 2016 Nov 4.

PMID:
27818346
11.

Human cytomegalovirus-based immunotherapy to treat glioblastoma: Into the future.

Duinkerken S, van Kooyk Y, Garcia-Vallejo JJ.

Oncoimmunology. 2016 Jul 25;5(9):e1214791. eCollection 2016.

12.

New roles for CD14 and IL-β linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cells.

Ilarregui JM, van Beelen AJ, Fehres CM, Bruijns SC, García-Vallejo JJ, van Kooyk Y.

Immunol Cell Biol. 2016 Nov;94(10):907-916. doi: 10.1038/icb.2016.66. Epub 2016 Aug 23.

PMID:
27550748
13.

A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources.

Gidwani K, Huhtinen K, Kekki H, van Vliet S, Hynninen J, Koivuviita N, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmäki U, Carpen O, van Kooyk Y, Pettersson K.

Clin Chem. 2016 Oct;62(10):1390-400. doi: 10.1373/clinchem.2016.257691. Epub 2016 Aug 18.

14.

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW.

Elife. 2016 Jun 23;5. pii: e13149. doi: 10.7554/eLife.13149.

15.

Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses.

Silva M, Silva Z, Marques G, Ferro T, Gonçalves M, Monteiro M, van Vliet SJ, Mohr E, Lino AC, Fernandes AR, Lima FA, van Kooyk Y, Matos T, Tadokoro CE, Videira PA.

Oncotarget. 2016 Jul 5;7(27):41053-41066. doi: 10.18632/oncotarget.9419.

16.

The Human Glycoprotein Salivary Agglutinin Inhibits the Interaction of DC-SIGN and Langerin with Oral Micro-Organisms.

Boks MA, Gunput ST, Kosten I, Gibbs S, van Vliet SJ, Ligtenberg AJ, van Kooyk Y.

J Innate Immun. 2016;8(4):350-61. doi: 10.1159/000443016. Epub 2016 Apr 16.

17.

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.

Streng-Ouwehand I, Ho NI, Litjens M, Kalay H, Boks MA, Cornelissen LA, Kaur Singh S, Saeland E, Garcia-Vallejo JJ, Ossendorp FA, Unger WW, van Kooyk Y.

Elife. 2016 Mar 21;5. pii: e11765. doi: 10.7554/eLife.11765.

18.

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells.

Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LA, Schetters ST, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WW.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3329-34. doi: 10.1073/pnas.1507706113. Epub 2016 Mar 3.

19.

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells.

Perdicchio M, Cornelissen LA, Streng-Ouwehand I, Engels S, Verstege MI, Boon L, Geerts D, van Kooyk Y, Unger WW.

Oncotarget. 2016 Feb 23;7(8):8771-82. doi: 10.18632/oncotarget.6822.

20.

Apoptotic vesicles as tumor vaccine.

Horrevorts SK, Garcia-Vallejo JJ, van Vliet SJ, van de Loosdrecht AA, van Kooyk Y, de Gruijl TD.

Immunotherapy. 2016;8(1):5-8. doi: 10.2217/imt.15.96. Epub 2015 Dec 7. No abstract available.

PMID:
26641072
21.

Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells.

Fehres CM, Bruijns SC, Sotthewes BN, Kalay H, Schaffer L, Head SR, de Gruijl TD, Garcia-Vallejo JJ, van Kooyk Y.

PLoS One. 2015 Nov 25;10(11):e0143519. doi: 10.1371/journal.pone.0143519. eCollection 2015.

22.

Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells.

Fehres CM, Duinkerken S, Bruijns SC, Kalay H, van Vliet SJ, Ambrosini M, de Gruijl TD, Unger WW, Garcia-Vallejo JJ, van Kooyk Y.

Cell Mol Immunol. 2017 Apr;14(4):360-370. doi: 10.1038/cmi.2015.87. Epub 2015 Oct 12.

PMID:
26456691
23.

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.

Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y.

Oncoimmunology. 2014 Oct 31;4(8):e970462. eCollection 2015 Aug.

24.

Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms.

Poncini CV, Ilarregui JM, Batalla EI, Engels S, Cerliani JP, Cucher MA, van Kooyk Y, González-Cappa SM, Rabinovich GA.

J Immunol. 2015 Oct 1;195(7):3311-24. doi: 10.4049/jimmunol.1403019. Epub 2015 Aug 31.

25.

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.

Lenos K, Goos JA, Vuist IM, den Uil SH, Delis-van Diemen PM, Belt EJ, Stockmann HB, Bril H, de Wit M, Carvalho B, Giblett S, Pritchard CA, Meijer GA, van Kooyk Y, Fijneman RJ, van Vliet SJ.

Oncotarget. 2015 Sep 22;6(28):26278-90. doi: 10.18632/oncotarget.4495.

26.

MPLA incorporation into DC-targeting glycoliposomes favours anti-tumour T cell responses.

Boks MA, Ambrosini M, Bruijns SC, Kalay H, van Bloois L, Storm G, Garcia-Vallejo JJ, van Kooyk Y.

J Control Release. 2015 Oct 28;216:37-46. doi: 10.1016/j.jconrel.2015.06.033. Epub 2015 Jul 4.

PMID:
26151293
27.

A new cellular target for Yersinia pestis.

Garcia-Vallejo JJ, van Kooyk Y.

Immunol Cell Biol. 2015 Oct;93(9):769-70. doi: 10.1038/icb.2015.60. Epub 2015 Jun 30. No abstract available.

PMID:
26124192
28.

DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde.

Garcia-Vallejo JJ, van Kooyk Y.

Immunity. 2015 Jun 16;42(6):983-5. doi: 10.1016/j.immuni.2015.05.021.

29.

In situ Delivery of Tumor Antigen- and Adjuvant-Loaded Liposomes Boosts Antigen-Specific T-Cell Responses by Human Dermal Dendritic Cells.

Boks MA, Bruijns SCM, Ambrosini M, Kalay H, van Bloois L, Storm G, Gruijl T, van Kooyk Y.

J Invest Dermatol. 2015 Nov;135(11):2697-2704. doi: 10.1038/jid.2015.226. Epub 2015 Jun 17.

30.

The primate autoimmune encephalomyelitis model; a bridge between mouse and man.

't Hart BA, van Kooyk Y, Geurts JJ, Gran B.

Ann Clin Transl Neurol. 2015 May;2(5):581-93. doi: 10.1002/acn3.194. Epub 2015 Mar 18. Review.

31.

Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1.

Koning N, Kessen SF, Van Der Voorn JP, Appelmelk BJ, Jeurink PV, Knippels LM, Garssen J, Van Kooyk Y.

Front Immunol. 2015 Mar 13;6:112. doi: 10.3389/fimmu.2015.00112. eCollection 2015.

32.

The Consequences of Multiple Simultaneous C-Type Lectin-Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN.

García-Vallejo JJ, Bloem K, Knippels LM, Garssen J, van Vliet SJ, van Kooyk Y.

Front Immunol. 2015 Mar 10;6:87. doi: 10.3389/fimmu.2015.00087. eCollection 2015.

33.

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens.

Fehres CM, Kalay H, Bruijns SC, Musaafir SA, Ambrosini M, van Bloois L, van Vliet SJ, Storm G, Garcia-Vallejo JJ, van Kooyk Y.

J Control Release. 2015 Apr 10;203:67-76. doi: 10.1016/j.jconrel.2015.01.040. Epub 2015 Feb 2.

PMID:
25656175
34.

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

Bakema JE, Tuk CW, van Vliet SJ, Bruijns SC, Vos JB, Letsiou S, Dijkstra CD, van Kooyk Y, Brenkman AB, van Egmond M.

J Immunol. 2015 Feb 15;194(4):1856-66. doi: 10.4049/jimmunol.1303126. Epub 2015 Jan 12.

35.

Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses.

Veninga H, Borg EG, Vreeman K, Taylor PR, Kalay H, van Kooyk Y, Kraal G, Martinez-Pomares L, den Haan JM.

Eur J Immunol. 2015 Mar;45(3):747-57. doi: 10.1002/eji.201444983. Epub 2015 Jan 14. Erratum in: Eur J Immunol. 2016 Feb;46(2):493.

36.

Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL.

van Kooyk Y, Ilarregui JM, van Vliet SJ.

Immunobiology. 2015 Feb;220(2):185-92. doi: 10.1016/j.imbio.2014.10.002. Epub 2014 Oct 14. Review.

PMID:
25454488
37.

Effective targeting of DC-SIGN by α-fucosylamide functionalized gold nanoparticles.

Arosio D, Chiodo F, Reina JJ, Marelli M, Penadés S, van Kooyk Y, Garcia-Vallejo JJ, Bernardi A.

Bioconjug Chem. 2014 Dec 17;25(12):2244-51. doi: 10.1021/bc500467u. Epub 2014 Nov 24.

PMID:
25379972
38.

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG.

García-Vallejo JJ, Ilarregui JM, Kalay H, Chamorro S, Koning N, Unger WW, Ambrosini M, Montserrat V, Fernandes RJ, Bruijns SC, van Weering JR, Paauw NJ, O'Toole T, van Horssen J, van der Valk P, Nazmi K, Bolscher JG, Bajramovic J, Dijkstra CD, 't Hart BA, van Kooyk Y.

J Exp Med. 2014 Jun 30;211(7):1465-83. doi: 10.1084/jem.20122192. Epub 2014 Jun 16.

39.

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming.

Fehres CM, Bruijns SC, van Beelen AJ, Kalay H, Ambrosini M, Hooijberg E, Unger WW, de Gruijl TD, van Kooyk Y.

Eur J Immunol. 2014 Aug;44(8):2415-24. doi: 10.1002/eji.201344094. Epub 2014 Jun 24.

40.

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer.

Fehres CM, Unger WW, Garcia-Vallejo JJ, van Kooyk Y.

Front Immunol. 2014 Apr 8;5:149. doi: 10.3389/fimmu.2014.00149. eCollection 2014. Review.

41.

Analytical tools for the study of cellular glycosylation in the immune system.

van Kooyk Y, Kalay H, Garcia-Vallejo JJ.

Front Immunol. 2013 Dec 11;4:451. doi: 10.3389/fimmu.2013.00451. Review.

42.

DCIR interacts with ligands from both endogenous and pathogenic origin.

Bloem K, Vuist IM, van den Berk M, Klaver EJ, van Die I, Knippels LM, Garssen J, García-Vallejo JJ, van Vliet SJ, van Kooyk Y.

Immunol Lett. 2014 Mar-Apr;158(1-2):33-41. doi: 10.1016/j.imlet.2013.11.007. Epub 2013 Nov 14.

PMID:
24239607
43.

Effects of antigen-expressing immunostimulatory liposomes on chemotaxis and maturation of dendritic cells in vitro and in human skin explants.

Lanzi A, Fehres CM, de Gruijl TD, van Kooyk Y, Mastrobattista E.

Pharm Res. 2014 Feb;31(2):516-26. doi: 10.1007/s11095-013-1179-0. Epub 2013 Sep 26.

PMID:
24072262
44.

Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).

van Vliet SJ, Vuist IM, Lenos K, Tefsen B, Kalay H, García-Vallejo JJ, van Kooyk Y.

J Biol Chem. 2013 Sep 20;288(38):27519-32. doi: 10.1074/jbc.M113.471045. Epub 2013 Aug 5.

45.

Enhanced glycan nanoprofiling by weak anion exchange preparative chromatography, mild acid desialylation, and nanoliquid chromatography-mass spectrometry with nanofluorescence detection.

Kalay H, Ambrosini M, Chiodo F, van Kooyk Y, García-Vallejo JJ.

Electrophoresis. 2013 Aug;34(16):2350-6. doi: 10.1002/elps.201200657. Epub 2013 Jul 26.

PMID:
23893432
46.

Skin-resident antigen-presenting cells: instruction manual for vaccine development.

Fehres CM, Garcia-Vallejo JJ, Unger WW, van Kooyk Y.

Front Immunol. 2013 Jun 20;4:157. doi: 10.3389/fimmu.2013.00157. eCollection 2013.

47.

In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunity.

Hesse C, Ginter W, Förg T, Mayer CT, Baru AM, Arnold-Schrauf C, Unger WW, Kalay H, van Kooyk Y, Berod L, Sparwasser T.

Eur J Immunol. 2013 Oct;43(10):2543-53. doi: 10.1002/eji.201343429. Epub 2013 Jul 22.

48.

Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain.

Bloem K, Vuist IM, van der Plas AJ, Knippels LM, Garssen J, García-Vallejo JJ, van Vliet SJ, van Kooyk Y.

PLoS One. 2013 Jun 11;8(6):e66266. doi: 10.1371/journal.pone.0066266. Print 2013.

49.

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion.

van Vliet SJ, Bay S, Vuist IM, Kalay H, García-Vallejo JJ, Leclerc C, van Kooyk Y.

J Leukoc Biol. 2013 Aug;94(2):315-23. doi: 10.1189/jlb.1012520. Epub 2013 Jun 6.

PMID:
23744646
50.

Intestinal epithelium-derived galectin-9 is involved in the immunomodulating effects of nondigestible oligosaccharides.

de Kivit S, Kraneveld AD, Knippels LM, van Kooyk Y, Garssen J, Willemsen LE.

J Innate Immun. 2013;5(6):625-38. doi: 10.1159/000350515. Epub 2013 May 28.

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