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Items: 1 to 50 of 123

1.

Senescent cells: a therapeutic target for cardiovascular disease.

Childs BG, Li H, van Deursen JM.

J Clin Invest. 2018 Apr 2;128(4):1217-1228. doi: 10.1172/JCI95146. Epub 2018 Apr 2.

2.

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.

Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z.

Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26.

PMID:
29581593
3.

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaam8574. doi: 10.1126/scitranslmed.aam8574.

PMID:
29118264
4.

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

El Yakoubi W, Buffin E, Cladière D, Gryaznova Y, Berenguer I, Touati SA, Gómez R, Suja JA, van Deursen JM, Wassmann K.

Nat Commun. 2017 Sep 25;8(1):694. doi: 10.1038/s41467-017-00774-3.

5.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT.

Cancer Cell. 2017 Sep 11;32(3):310-323.e5. doi: 10.1016/j.ccell.2017.08.002. Epub 2017 Aug 31.

PMID:
28867147
6.

Senescent cells: an emerging target for diseases of ageing.

Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM.

Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21. Review.

PMID:
28729727
7.

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.

8.

Oncogenic senescence: a multi-functional perspective.

Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J.

Oncotarget. 2017 Apr 18;8(16):27661-27672. doi: 10.18632/oncotarget.15742.

9.

Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH.

Aging Cell. 2017 Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6.

10.

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.

Choi KM, Hong SJ, van Deursen JM, Kim S, Kim KH, Lee CK.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):29-38. doi: 10.1093/gerona/glx024.

PMID:
28329151
11.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.

Nucleic Acids Res. 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107.

12.

Singling Out Chromosome Gains in Tumor Evolution.

Naylor RM, van Deursen JM.

Cancer Cell. 2017 Feb 13;31(2):165-166. doi: 10.1016/j.ccell.2017.01.011.

13.

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK.

Gastroenterology. 2017 Apr;152(5):1126-1138.e6. doi: 10.1053/j.gastro.2016.12.037. Epub 2017 Jan 5.

PMID:
28065787
14.

Cellular senescence in renal ageing and disease.

Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM.

Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Review.

PMID:
28029153
15.

The progeroid gene BubR1 regulates axon myelination and motor function.

Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH.

Aging (Albany NY). 2016 Sep 12;8(11):2667-2688. doi: 10.18632/aging.101032.

16.

Aneuploidy in Cancer and Aging.

Naylor RM, van Deursen JM.

Annu Rev Genet. 2016 Nov 23;50:45-66. Review.

17.

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.

18.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

19.

Deciphering the tumor suppressive mechanisms of Pten.

van Ree JH, van Deursen JM.

Cell Cycle. 2016 Dec 16;15(24):3329-3330. doi: 10.1080/15384101.2016.1229011. Epub 2016 Aug 30. No abstract available.

20.

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.

21.

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Booij HG, Yu H, De Boer RA, van de Kolk CW, van de Sluis B, Van Deursen JM, Van Gilst WH, Silljé HH, Westenbrink BD.

Cardiovasc Res. 2016 Aug 1;111(3):217-26. doi: 10.1093/cvr/cvw161. Epub 2016 Jun 14.

PMID:
27302402
22.

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.

Nat Cell Biol. 2016 Jul;18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.

23.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MA, Kloosterhuis NJ, Melki R, van Cruchten RT, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TP, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 12. pii: S1097-2765(16)00227-6. doi: 10.1016/j.molcel.2016.03.017. [Epub ahead of print]

24.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

25.

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T.

Stroke. 2016 Apr;47(4):1068-77. doi: 10.1161/STROKEAHA.115.010835. Epub 2016 Feb 16.

26.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

27.

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.

Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R.

J Clin Invest. 2016 Feb;126(2):706-20. doi: 10.1172/JCI78132. Epub 2016 Jan 5.

28.

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.

Naylor RM, Jeganathan KB, Cao X, van Deursen JM.

J Clin Invest. 2016 Feb;126(2):543-59. doi: 10.1172/JCI82277. Epub 2016 Jan 5.

29.

Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Childs BG, Durik M, Baker DJ, van Deursen JM.

Nat Med. 2015 Dec;21(12):1424-35. doi: 10.1038/nm.4000. Review.

30.

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.

van Ree JH, Nam HJ, van Deursen JM.

Chromosome Res. 2016 Jan;24(1):67-76. doi: 10.1007/s10577-015-9501-9. Review.

31.

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E.

J Cell Biol. 2015 Nov 9;211(3):605-17. doi: 10.1083/jcb.201505108.

32.

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z.

Mol Cell. 2015 Oct 1;60(1):21-34. doi: 10.1016/j.molcel.2015.08.011. Epub 2015 Sep 17.

33.

B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.

Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L.

PLoS One. 2015 Jun 11;10(6):e0130126. doi: 10.1371/journal.pone.0130126. eCollection 2015.

34.

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest.

Touati SA, Buffin E, Cladière D, Hached K, Rachez C, van Deursen JM, Wassmann K.

Nat Commun. 2015 Apr 21;6:6946. doi: 10.1038/ncomms7946.

35.

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ.

Oncogene. 2016 Jan 21;35(3):279-89. doi: 10.1038/onc.2015.92. Epub 2015 Apr 20.

36.

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma.

Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-Zapico ME, Roberts LR.

Hepatology. 2015 Apr;61(4):1269-83. doi: 10.1002/hep.27658. Epub 2015 Feb 13.

37.

Spartan deficiency causes genomic instability and progeroid phenotypes.

Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ.

Nat Commun. 2014 Dec 11;5:5744. doi: 10.1038/ncomms6744.

38.

Centrosome dynamics as a source of chromosomal instability.

Nam HJ, Naylor RM, van Deursen JM.

Trends Cell Biol. 2015 Feb;25(2):65-73. doi: 10.1016/j.tcb.2014.10.002. Epub 2014 Nov 7. Review.

39.

Senescence and apoptosis: dueling or complementary cell fates?

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM.

EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. Review.

40.

The role of senescent cells in ageing.

van Deursen JM.

Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193. Review.

41.

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.

EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12.

42.

Cyclin B2 and p53 control proper timing of centrosome separation.

Nam HJ, van Deursen JM.

Nat Cell Biol. 2014 Jun;16(6):538-49. doi: 10.1038/ncb2952. Epub 2014 Apr 28. Erratum in: Nat Cell Biol. 2014 Oct;16(10):1027.

43.

Impact of genomic damage and ageing on stem cell function.

Behrens A, van Deursen JM, Rudolph KL, Schumacher B.

Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928. Review.

44.

Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

Sedivy JM, van Deursen JM.

Longev Healthspan. 2013 Apr 22;2(1):7. doi: 10.1186/2046-2395-2-7.

45.

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.

Baker DJ, Weaver RL, van Deursen JM.

Cell Rep. 2013 Apr 25;3(4):1164-74. doi: 10.1016/j.celrep.2013.03.028. Epub 2013 Apr 18.

46.

Aneuploidy in health, disease, and aging.

Ricke RM, van Deursen JM.

J Cell Biol. 2013 Apr 1;201(1):11-21. doi: 10.1083/jcb.201301061. Review.

47.

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M.

Cell Rep. 2013 Feb 21;3(2):552-66. doi: 10.1016/j.celrep.2013.01.003. Epub 2013 Jan 31.

48.

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM.

PLoS Genet. 2012;8(12):e1003138. doi: 10.1371/journal.pgen.1003138. Epub 2012 Dec 27.

49.

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM.

Nat Cell Biol. 2013 Jan;15(1):96-102. doi: 10.1038/ncb2643. Epub 2012 Dec 16.

50.

Senescent cells: a novel therapeutic target for aging and age-related diseases.

Naylor RM, Baker DJ, van Deursen JM.

Clin Pharmacol Ther. 2013 Jan;93(1):105-16. doi: 10.1038/clpt.2012.193. Epub 2012 Dec 5. Review.

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