Sort by
Items per page

Send to

Choose Destination

Search results

Items: 33


BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats.

Wang D, Berglund AE, Kenchappa RS, MacAulay RJ, Mulé JJ, Etame AB.

Sci Rep. 2017 Aug 24;7(1):9350. doi: 10.1038/s41598-017-09503-8.


Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.

Fell SM, Li S, Wallis K, Kock A, Surova O, Rraklli V, Höfig CS, Li W, Mittag J, Henriksson MA, Kenchappa RS, Holmberg J, Kogner P, Schlisio S.

Genes Dev. 2017 May 15;31(10):1036-1053. doi: 10.1101/gad.297077.117.


Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation.

Kenchappa R, Bodke YD, Telkar S, Aruna Sindhe M.

J Chem Biol. 2016 Sep 8;10(1):11-23. doi: 10.1007/s12154-016-0160-x. eCollection 2017 Jan.


Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

Sindhe MA, Bodke YD, Kenchappa R, Telkar S, Chandrashekar A.

J Chem Biol. 2016 Jul 7;9(3):79-90. doi: 10.1007/s12154-016-0153-9. eCollection 2016 Jul.


A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature.

Fedorenko IV, Evernden B, Kenchappa RS, Sahebjam S, Ryzhova E, Puskas J, McIntosh L, Caceres G, Magliocco A, Etame A, Harbour JW, Smalley KS, Forsyth PA.

Melanoma Res. 2016 Oct;26(5):481-6. doi: 10.1097/CMR.0000000000000274. Review.


XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.

Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX.

Oncotarget. 2016 Jun 7;7(23):34229-39. doi: 10.18632/oncotarget.8748.


Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.

Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA.

Int J Cancer. 2016 Sep 15;139(6):1195-201. doi: 10.1002/ijc.30147. Epub 2016 Apr 30. Review.


M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma.

Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA.

Neuro Oncol. 2016 Mar 8. pii: now006. [Epub ahead of print]


BIRC3 is a novel driver of therapeutic resistance in Glioblastoma.

Wang D, Berglund A, Kenchappa RS, Forsyth PA, Mulé JJ, Etame AB.

Sci Rep. 2016 Feb 18;6:21710. doi: 10.1038/srep21710.


The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.

Li S, Fell SM, Surova O, Smedler E, Wallis K, Chen ZX, Hellman U, Johnsen JI, Martinsson T, Kenchappa RS, Uhlén P, Kogner P, Schlisio S.

Dev Cell. 2016 Jan 25;36(2):164-78. doi: 10.1016/j.devcel.2015.12.029.


In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells.

McKenzie BA, Zemp FJ, Pisklakova A, Narendran A, McFadden G, Lun X, Kenchappa RS, Kurz EU, Forsyth PA.

Neuro Oncol. 2015 Aug;17(8):1086-94. doi: 10.1093/neuonc/nou359. Epub 2015 Jan 20.


Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.

Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher DA, Fournier M, Vrionis FD, Tran N, Chan JA, Kenchappa RS, Forsyth PA.

J Biol Chem. 2015 Feb 6;290(6):3814-24. doi: 10.1074/jbc.M114.599373. Epub 2014 Dec 23.


p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS.

J Biol Chem. 2014 Mar 21;289(12):8067-85. doi: 10.1074/jbc.M113.513762. Epub 2014 Feb 11.


RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.

Chen ZX, Wallis K, Fell SM, Sobrado VR, Hemmer MC, Ramsköld D, Hellman U, Sandberg R, Kenchappa RS, Martinson T, Johnsen JI, Kogner P, Schlisio S.

Cancer Discov. 2014 Apr;4(4):434-51. doi: 10.1158/2159-8290.CD-13-0362. Epub 2014 Jan 27.


Novel treatments for melanoma brain metastases.

Kenchappa RS, Tran N, Rao NG, Smalley KS, Gibney GT, Sondak VK, Forsyth PA.

Cancer Control. 2013 Oct;20(4):298-306. Review.


Protein S deficiency in a case of superor sagital vein thrombosis.

Nagesh Kumar TC, Kenchappa R, Kempegowda MB, Kulkarni A.

Indian J Med Sci. 2011 Jan;65(1):36-9. doi: 10.4103/0019-5359.103170.


Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.

Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG Jr, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER.

Endocr Relat Cancer. 2010 Dec 21;18(1):73-83. doi: 10.1677/ERC-10-0113. Print 2011 Feb.


p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.

Kenchappa RS, Tep C, Korade Z, Urra S, Bronfman FC, Yoon SO, Carter BD.

J Biol Chem. 2010 Jun 25;285(26):20358-68. doi: 10.1074/jbc.M109.082834. Epub 2010 Apr 26.


Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor.

Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF.

J Cell Sci. 2009 Sep 15;122(Pt 18):3351-7. doi: 10.1242/jcs.055061. Epub 2009 Aug 25.


Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.

Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ibáñez CF.

Neuron. 2009 Apr 16;62(1):72-83. doi: 10.1016/j.neuron.2009.02.020.


Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.

Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, Carter BD, Friedman WJ.

J Neurosci. 2008 Sep 24;28(39):9870-9. doi: 10.1523/JNEUROSCI.2841-08.2008.


NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.

Bertrand MJ, Kenchappa RS, Andrieu D, Leclercq-Smekens M, Nguyen HN, Carter BD, Muscatelli F, Barker PA, De Backer O.

Cell Death Differ. 2008 Dec;15(12):1921-9. doi: 10.1038/cdd.2008.127. Epub 2008 Sep 5.


NRIF is a regulator of neuronal cholesterol biosynthesis genes.

Korade Z, Kenchappa RS, Mirnics K, Carter BD.

J Mol Neurosci. 2009 Jun;38(2):152-8. doi: 10.1007/s12031-008-9136-9. Epub 2008 Aug 2.


The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.

Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr.

Genes Dev. 2008 Apr 1;22(7):884-93. doi: 10.1101/gad.1648608. Epub 2008 Mar 11.


Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity.

Diwakar L, Kenchappa RS, Annepu J, Ravindranath V.

Neurochem Int. 2007 Jul;51(1):37-46. Epub 2007 Apr 5.


Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS.

Diwakar L, Kenchappa RS, Annepu J, Saeed U, Sujanitha R, Ravindranath V.

Brain Res. 2006 Dec 13;1125(1):176-84. Epub 2006 Nov 14.


Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.

Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD.

Neuron. 2006 Apr 20;50(2):219-32.


TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor.

Geetha T, Kenchappa RS, Wooten MW, Carter BD.

EMBO J. 2005 Nov 16;24(22):3859-68. Epub 2005 Oct 27.


Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP-mediated neurodegeneration.

Kenchappa RS, Diwakar L, Annepu J, Ravindranath V.

FASEB J. 2004 Jul;18(10):1102-4. Epub 2004 May 7.


Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP.

Kenchappa RS, Ravindranath V.

FASEB J. 2003 Apr;17(6):717-9. Epub 2003 Feb 19.


Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury.

Kenchappa RS, Diwakar L, Boyd MR, Ravindranath V.

J Neurosci. 2002 Oct 1;22(19):8402-10.


Supplemental Content

Loading ...
Support Center