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Items: 1 to 50 of 116

1.

Repressing the repressor: Ezh2 mediates macrophage activation.

Neele AE, de Winther MPJ.

J Exp Med. 2018 May 7;215(5):1269-1271. doi: 10.1084/jem.20180479. Epub 2018 Apr 24.

PMID:
29691302
2.

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.

van der Tuin SJL, Li Z, Berbée JFP, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K, Wang Y.

J Am Heart Assoc. 2018 Mar 10;7(6). pii: e008105. doi: 10.1161/JAHA.117.008105.

3.

Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction.

Maracle CX, Agca R, Helder B, Meeuwsen JAL, Niessen HWM, Biessen EAL, de Winther MPJ, de Jager SCA, Nurmohamed MT, Tas SW.

Atherosclerosis. 2018 Mar;270:33-41. doi: 10.1016/j.atherosclerosis.2018.01.032. Epub 2018 Jan 31.

4.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

5.

DARC matter(s) for inflammatory cells.

Atzler D, de Winther MPJ.

Cardiovasc Res. 2018 Feb 1;114(2):e11-e13. doi: 10.1093/cvr/cvx230. No abstract available.

PMID:
29373721
6.

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard B, Neidhart M, Stroes ESG, Catapano AL, Bekkering S.

Eur Heart J. 2017 Oct 24. doi: 10.1093/eurheartj/ehx581. [Epub ahead of print]

7.

IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.

van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V.

Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30.

PMID:
28852207
8.

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ.

J Mol Endocrinol. 2017 Oct;59(3):245-255. doi: 10.1530/JME-17-0112. Epub 2017 Jul 10.

PMID:
28694301
9.

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.

10.

High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis.

de Ronde MWJ, Kok MGM, Moerland PD, Van den Bossche J, Neele AE, Halliani A, van der Made I, de Winther MPJ, Meijers JCM, Creemers EE, Pinto-Sietsma SJ.

Atherosclerosis. 2017 Aug;263:377-384. doi: 10.1016/j.atherosclerosis.2017.03.045. Epub 2017 Apr 5.

11.

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia.

Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema MA, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG.

Eur Heart J. 2017 May 21;38(20):1584-1593. doi: 10.1093/eurheartj/ehx002.

PMID:
28329114
12.

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells.

Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP.

Epigenomics. 2017 Apr;9(4):383-391. doi: 10.2217/epi-2016-0152. Epub 2017 Mar 21.

PMID:
28322580
13.

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.

Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2766-E2775. doi: 10.1073/pnas.1618411114. Epub 2017 Mar 14.

14.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC.

Cell Metab. 2017 Jan 10;25(1):197-207. doi: 10.1016/j.cmet.2016.10.013. Epub 2016 Nov 17.

15.

Immune Modulation of Brown(ing) Adipose Tissue in Obesity.

van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E.

Endocr Rev. 2017 Feb 1;38(1):46-68. doi: 10.1210/er.2016-1066. Review.

PMID:
27849358
16.

Epigenetic Regulation of Monocyte and Macrophage Function.

Hoeksema MA, de Winther MP.

Antioxid Redox Signal. 2016 Nov 10;25(14):758-774. Epub 2016 Apr 25. Review.

17.

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP.

Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008.

18.

Epigenetic mechanisms of macrophage activation in type 2 diabetes.

Ahmed M, de Winther MPJ, Van den Bossche J.

Immunobiology. 2017 Oct;222(10):937-943. doi: 10.1016/j.imbio.2016.08.011. Epub 2016 Sep 3. Review.

19.

Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes.

Stöger JL, Boshuizen MC, Brufau G, Gijbels MJ, Wolfs IM, van der Velden S, Pöttgens CC, Vergouwe MN, Wijnands E, Beckers L, Goossens P, Kerksiek A, Havinga R, Müller W, Lütjohann D, Groen AK, de Winther MP.

Thromb Haemost. 2016 Aug 30;116(3):565-77. doi: 10.1160/TH16-01-0043. Epub 2016 Jun 30.

PMID:
27358035
20.

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lütjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbée JFP.

Atherosclerosis. 2016 Aug;251:6-14. doi: 10.1016/j.atherosclerosis.2016.05.031. Epub 2016 May 19.

21.

Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro.

Allijn IE, Vaessen SF, Quarles van Ufford LC, Beukelman KJ, de Winther MP, Storm G, Schiffelers RM.

PLoS One. 2016 May 10;11(5):e0155325. doi: 10.1371/journal.pone.0155325. eCollection 2016.

22.

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling.

Hoeksema MA, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G.

FASEB J. 2016 Aug;30(8):2826-36. doi: 10.1096/fj.201600343R. Epub 2016 Apr 19.

PMID:
27095802
23.

Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.

Boshuizen MC, Neele AE, Gijbels MJ, van der Velden S, Hoeksema MA, Forman RA, Muller W, Van den Bossche J, de Winther MP.

Atherosclerosis. 2016 Mar;246:325-33. doi: 10.1016/j.atherosclerosis.2016.01.026. Epub 2016 Jan 19.

PMID:
26828750
24.

The Plot Thickens Further for Type I Interferons in Atherosclerotic Disease.

de Winther MP.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):217-8. doi: 10.1161/ATVBAHA.115.306907. No abstract available.

25.

Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.

van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E.

FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26.

PMID:
26813974
26.

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis.

Van den Bossche J, Baardman J, de Winther MP.

J Vis Exp. 2015 Nov 28;(105). doi: 10.3791/53424.

27.

Metabolic-epigenetic crosstalk in macrophage activation.

Baardman J, Licht I, de Winther MP, Van den Bossche J.

Epigenomics. 2015 Oct;7(7):1155-64. doi: 10.2217/epi.15.71. Epub 2015 Nov 20.

28.

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms.

Boshuizen MC, Hoeksema MA, Neele AE, van der Velden S, Hamers AA, Van den Bossche J, Lutgens E, de Winther MP.

Cytokine. 2016 Jan;77:220-6. doi: 10.1016/j.cyto.2015.09.016. Epub 2015 Oct 1.

PMID:
26427927
29.

Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency.

Szilagyi K, Gazendam RP, van Hamme JL, Tool AT, van Houdt M, Vos WA, Verkuijlen P, Janssen H, Belot A, Juillard L, Förster-Waldl E, Boztug K, Kraal G, de Winther MP, Kuijpers TW, van den Berg TK.

J Allergy Clin Immunol. 2015 Nov;136(5):1404-7.e1-10. doi: 10.1016/j.jaci.2015.06.016. Epub 2015 Jul 30. No abstract available.

PMID:
26233929
30.

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis.

Neele AE, Van den Bossche J, Hoeksema MA, de Winther MP.

Eur J Pharmacol. 2015 Sep 15;763(Pt A):79-89. doi: 10.1016/j.ejphar.2015.03.101. Epub 2015 May 21. Review.

PMID:
26004034
31.

Interferons as Essential Modulators of Atherosclerosis.

Boshuizen MC, de Winther MP.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1579-88. doi: 10.1161/ATVBAHA.115.305464. Epub 2015 May 7. Review.

32.

MAb therapy against the IFN-α/β receptor subunit 1 stimulates arteriogenesis in a murine hindlimb ischaemia model without enhancing atherosclerotic burden.

Teunissen PF, Boshuizen MC, Hollander MR, Biesbroek PS, van der Hoeven NW, Mol JQ, Gijbels MJ, van der Velden S, van der Pouw Kraan TC, Horrevoets AJ, de Winther MP, van Royen N.

Cardiovasc Res. 2015 Jul 15;107(2):255-66. doi: 10.1093/cvr/cvv138. Epub 2015 May 1.

PMID:
25935869
33.

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.

Hoeksema MA, Scicluna BP, Boshuizen MC, van der Velden S, Neele AE, Van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MP.

J Immunol. 2015 Apr 15;194(8):3909-16. doi: 10.4049/jimmunol.1402077. Epub 2015 Mar 6.

34.

Dectin-1 deficiency does not affect atherosclerosis development in mice.

Szilagyi K, Gijbels MJ, van der Velden S, Heinsbroek SE, Kraal G, de Winther MP, van den Berg TK.

Atherosclerosis. 2015 Apr;239(2):318-21. doi: 10.1016/j.atherosclerosis.2015.02.005. Epub 2015 Feb 7.

35.

Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.

van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM.

Am J Pathol. 2015 Apr;185(4):1145-55. doi: 10.1016/j.ajpath.2014.11.028. Epub 2015 Feb 7.

PMID:
25659879
36.

Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study.

Kornmann LM, Zernecke A, Curfs DM, Janssen BJ, Weber C, de Winther MP, Reneman RS, Hoeks AP, Reesink KD.

Cardiovasc Ultrasound. 2015 Jan 8;13:1. doi: 10.1186/1476-7120-13-1.

37.

Salsalate activates brown adipose tissue in mice.

van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR.

Diabetes. 2015 May;64(5):1544-54. doi: 10.2337/db14-1125. Epub 2014 Dec 4.

38.

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.

Van den Bossche J, Neele AE, Hoeksema MA, de Heij F, Boshuizen MC, van der Velden S, de Boer VC, Reedquist KA, de Winther MP.

Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):396-402. doi: 10.1016/j.bbrc.2014.11.029. Epub 2014 Nov 18.

PMID:
25446073
39.

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.

van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E.

Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13.

PMID:
25394307
40.

PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages.

Szilagyi K, Meijer AB, Neele AE, Verkuijlen P, Leitges M, Dabernat S, Förster-Waldl E, Boztug K, Belot A, Kuijpers TW, Kraal G, de Winther MP, van den Berg TK.

Cardiovasc Res. 2014 Dec 1;104(3):467-76. doi: 10.1093/cvr/cvu213. Epub 2014 Sep 24.

PMID:
25253077
41.

Macrophage polarization: the epigenetic point of view.

Van den Bossche J, Neele AE, Hoeksema MA, de Winther MP.

Curr Opin Lipidol. 2014 Oct;25(5):367-73. doi: 10.1097/MOL.0000000000000109. Review.

PMID:
25188918
42.

Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses.

Jetten N, Roumans N, Gijbels MJ, Romano A, Post MJ, de Winther MP, van der Hulst RR, Xanthoulea S.

PLoS One. 2014 Jul 28;9(7):e102994. doi: 10.1371/journal.pone.0102994. eCollection 2014.

43.

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.

Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP.

EMBO Mol Med. 2014 Sep;6(9):1124-32. doi: 10.15252/emmm.201404170.

44.

Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Döring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H.

PLoS One. 2014 Feb 3;9(2):e87452. doi: 10.1371/journal.pone.0087452. eCollection 2014.

45.

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis.

Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E.

FASEB J. 2014 May;28(5):2202-13. doi: 10.1096/fj.13-243105. Epub 2014 Jan 30.

PMID:
24481967
46.

MiR-92a: at the heart of lipid-driven endothelial dysfunction.

de Winther MP, Lutgens E.

Circ Res. 2014 Jan 31;114(3):399-401. doi: 10.1161/CIRCRESAHA.114.303125. No abstract available.

47.

Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia.

Wijnands KA, Hoeksema MA, Meesters DM, van den Akker NM, Molin DG, Briedé JJ, Ghosh M, Köhler SE, van Zandvoort MA, de Winther MP, Buurman WA, Lamers WH, Poeze M.

PLoS One. 2014 Jan 21;9(1):e86135. doi: 10.1371/journal.pone.0086135. eCollection 2014.

48.

Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies.

Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O.

Circ Res. 2014 Jan 3;114(1):214-26. doi: 10.1161/CIRCRESAHA.114.302355. Review.

49.

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

Boon MR, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC.

PLoS One. 2013 Sep 16;8(9):e74083. doi: 10.1371/journal.pone.0074083. eCollection 2013.

50.

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis.

Wolfs IM, Stöger JL, Goossens P, Pöttgens C, Gijbels MJ, Wijnands E, van der Vorst EP, van Gorp P, Beckers L, Engel D, Biessen EA, Kraal G, van Die I, Donners MM, de Winther MP.

FASEB J. 2014 Jan;28(1):288-99. doi: 10.1096/fj.13-235911. Epub 2013 Sep 16.

PMID:
24043262

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