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Items: 1 to 50 of 55

1.

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z.

Nat Commun. 2017 Oct 16;8(1):947. doi: 10.1038/s41467-017-00983-w.

2.

The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor.

Survery S, Moparthi L, Kjellbom P, Högestätt ED, Zygmunt PM, Johanson U.

J Biol Chem. 2016 Dec 23;291(52):26899-26912. doi: 10.1074/jbc.M116.743443. Epub 2016 Nov 14.

3.

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.

Moparthi L, Kichko TI, Eberhardt M, Högestätt ED, Kjellbom P, Johanson U, Reeh PW, Leffler A, Filipovic MR, Zygmunt PM.

Sci Rep. 2016 Jun 28;6:28763. doi: 10.1038/srep28763.

4.

Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.

Babes A, Sauer SK, Moparthi L, Kichko TI, Neacsu C, Namer B, Filipovic M, Zygmunt PM, Reeh PW, Fischer MJ.

J Neurosci. 2016 May 11;36(19):5264-78. doi: 10.1523/JNEUROSCI.4268-15.2016.

5.

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.

Moparthi L, Survery S, Kreir M, Simonsen C, Kjellbom P, Högestätt ED, Johanson U, Zygmunt PM.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16901-6. doi: 10.1073/pnas.1412689111. Epub 2014 Nov 11.

6.

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.

Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR.

Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381.

7.

TRPA1.

Zygmunt PM, Högestätt ED.

Handb Exp Pharmacol. 2014;222:583-630. doi: 10.1007/978-3-642-54215-2_23. Review.

PMID:
24756722
8.

Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1.

Zygmunt PM, Ermund A, Movahed P, Andersson DA, Simonsen C, Jönsson BA, Blomgren A, Birnir B, Bevan S, Eschalier A, Mallet C, Gomis A, Högestätt ED.

PLoS One. 2013 Dec 2;8(12):e81618. doi: 10.1371/journal.pone.0081618. eCollection 2013.

9.

TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells.

Alenmyr L, Uller L, Greiff L, Högestätt ED, Zygmunt PM.

Basic Clin Pharmacol Toxicol. 2014 Feb;114(2):210-6. doi: 10.1111/bcpt.12135. Epub 2013 Oct 1.

10.

Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain.

Barrière DA, Mallet C, Blomgren A, Simonsen C, Daulhac L, Libert F, Chapuy E, Etienne M, Högestätt ED, Zygmunt PM, Eschalier A.

PLoS One. 2013 Aug 5;8(8):e70690. doi: 10.1371/journal.pone.0070690. Print 2013.

11.

TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.

Moilanen LJ, Laavola M, Kukkonen M, Korhonen R, Leppänen T, Högestätt ED, Zygmunt PM, Nieminen RM, Moilanen E.

Sci Rep. 2012;2:380. doi: 10.1038/srep00380. Epub 2012 Apr 24.

12.

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.

Andersson DA, Gentry C, Alenmyr L, Killander D, Lewis SE, Andersson A, Bucher B, Galzi JL, Sterner O, Bevan S, Högestätt ED, Zygmunt PM.

Nat Commun. 2011 Nov 22;2:551. doi: 10.1038/ncomms1559.

PMID:
22109525
13.

TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.

Alenmyr L, Herrmann A, Högestätt ED, Greiff L, Zygmunt PM.

Clin Physiol Funct Imaging. 2011 Nov;31(6):435-44. doi: 10.1111/j.1475-097X.2011.01039.x. Epub 2011 Jul 26.

PMID:
21981454
14.

Effect of mucosal TRPV1 inhibition in allergic rhinitis.

Alenmyr L, Greiff L, Andersson M, Sterner O, Zygmunt PM, Högestätt ED.

Basic Clin Pharmacol Toxicol. 2012 Mar;110(3):264-8. doi: 10.1111/j.1742-7843.2011.00803.x. Epub 2011 Oct 25.

15.

Channels: A TR(i)P in the air.

Zygmunt PM.

Nat Chem Biol. 2011 Sep 19;7(10):661-3. doi: 10.1038/nchembio.669. No abstract available. Erratum in: Nat Chem Biol. 2011 Nov;7(11):853.

PMID:
21931315
16.

TRPV1 in brain is involved in acetaminophen-induced antinociception.

Mallet C, Barrière DA, Ermund A, Jönsson BA, Eschalier A, Zygmunt PM, Högestätt ED.

PLoS One. 2010 Sep 17;5(9). pii: e12748. doi: 10.1371/journal.pone.0012748.

17.

In vitro TRPV1 activity of piperine derived amides.

Correa EA, Högestätt ED, Sterner O, Echeverri F, Zygmunt PM.

Bioorg Med Chem. 2010 May 1;18(9):3299-306. doi: 10.1016/j.bmc.2010.03.013. Epub 2010 Mar 11.

PMID:
20381363
18.

Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain.

Axelsson HE, Minde JK, Sonesson A, Toolanen G, Högestätt ED, Zygmunt PM.

Neuroscience. 2009 Sep 15;162(4):1322-32. doi: 10.1016/j.neuroscience.2009.05.052. Epub 2009 May 29.

PMID:
19482060
19.

TRPV1-mediated itch in seasonal allergic rhinitis.

Alenmyr L, Högestätt ED, Zygmunt PM, Greiff L.

Allergy. 2009 May;64(5):807-10. doi: 10.1111/j.1398-9995.2009.01937.x. Epub 2009 Feb 13.

20.

Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.

Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Högestätt ED, Zygmunt PM.

Eur Urol. 2008 Feb;53(2):391-9. Epub 2007 Oct 22.

PMID:
18031925
21.
22.
23.

Pungent products from garlic activate the sensory ion channel TRPA1.

Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12248-52. Epub 2005 Aug 15.

24.

Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.

Movahed P, Jönsson BA, Birnir B, Wingstrand JA, Jørgensen TD, Ermund A, Sterner O, Zygmunt PM, Högestätt ED.

J Biol Chem. 2005 Nov 18;280(46):38496-504. Epub 2005 Aug 4.

25.

Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.

Movahed P, Evilevitch V, Andersson TL, Jönsson BA, Wollmer P, Zygmunt PM, Högestätt ED.

Br J Pharmacol. 2005 Sep;146(2):171-9.

26.

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.

Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM.

J Biol Chem. 2005 Sep 9;280(36):31405-12. Epub 2005 Jun 29.

27.

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.

Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D.

Nature. 2004 Jan 15;427(6971):260-5. Epub 2004 Jan 7.

PMID:
14712238
28.

Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists.

Andersson DA, Adner M, Högestätt ED, Zygmunt PM.

Mol Pharmacol. 2002 Sep;62(3):705-13. Erratum in: Mol Pharmacol 2002 Oct;62(4):968.

29.

Cardiovascular pharmacology of anandamide.

Högestätt ED, Zygmunt PM.

Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):343-51. Review.

PMID:
12052048
31.
32.

Differential actions of anandamide, potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig basilar artery.

Zygmunt PM, Sørgård M, Petersson J, Johansson R, Högestätt ED.

Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):535-42.

PMID:
10832608
33.

The anandamide transport inhibitor AM404 activates vanilloid receptors.

Zygmunt PM, Chuang H, Movahed P, Julius D, Högestätt ED.

Eur J Pharmacol. 2000 May 12;396(1):39-42.

PMID:
10822052
34.

Involvement of sensory nerves in vasodilator responses to acetylcholine and potassium ions in rat hepatic artery.

Högestätt ED, Johansson R, Andersson DA, Zygmunt PM.

Br J Pharmacol. 2000 May;130(1):27-32.

36.

Anandamide - the other side of the coin.

Zygmunt PM, Julius I, Di Marzo I, Högestätt ED.

Trends Pharmacol Sci. 2000 Feb;21(2):43-4. No abstract available.

PMID:
10664604
37.

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.

Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED.

Nature. 1999 Jul 29;400(6743):452-7.

PMID:
10440374
38.

Endothelial P2Y receptors induce hyperpolarisation of vascular smooth muscle by release of endothelium-derived hyperpolarising factor.

Malmsjö M, Erlinge D, Högestätt ED, Zygmunt PM.

Eur J Pharmacol. 1999 Jan 8;364(2-3):169-73.

PMID:
9932720
39.
40.

Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF.

Zygmunt PM, Plane F, Paulsson M, Garland CJ, Högestätt ED.

Br J Pharmacol. 1998 Jul;124(5):992-1000.

41.

Studies on the effects of anandamide in rat hepatic artery.

Zygmunt PM, Högestätt ED, Waldeck K, Edwards G, Kirkup AJ, Weston AH.

Br J Pharmacol. 1997 Dec;122(8):1679-86.

42.

Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery.

Zygmunt PM, Edwards G, Weston AH, Larsson B, Högestätt ED.

Br J Pharmacol. 1997 May;121(1):141-9.

43.

Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries.

Petersson J, Zygmunt PM, Högestätt ED.

Br J Pharmacol. 1997 Apr;120(7):1344-50.

44.

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein.

Edwards G, Zygmunt PM, Högestätt ED, Weston AH.

Br J Pharmacol. 1996 Oct;119(4):691-701.

45.

Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery.

Zygmunt PM, Edwards G, Weston AH, Davis SC, Högestätt ED.

Br J Pharmacol. 1996 Jul;118(5):1147-52.

46.
47.
48.

Substance P-induced relaxation and hyperpolarization in human cerebral arteries.

Petersson J, Zygmunt PM, Brandt L, Högestätt ED.

Br J Pharmacol. 1995 Jul;115(6):889-94.

49.

NANC neurotransmission in lamina propria of the rabbit urethra: regulation by different subsets of calcium channels.

Zygmunt PK, Zygmunt PM, Högestätt ED, Andersson KE.

Br J Pharmacol. 1995 Jul;115(6):1020-6.

50.

The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery.

Zygmunt PM, Waldeck K, Högestätt ED.

Acta Physiol Scand. 1994 Dec;152(4):375-84.

PMID:
7701938

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