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Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection.

Farnsworth CW, Schott EM, Benvie AM, Zukoski J, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA.

J Orthop Res. 2017 Dec 11. doi: 10.1002/jor.23831. [Epub ahead of print]


DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ.

JCI Insight. 2017 Jun 15;2(12). pii: 93612. doi: 10.1172/jci.insight.93612. [Epub ahead of print]


Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.

Dar QA, Schott EM, Catheline SE, Maynard RD, Liu Z, Kamal F, Farnsworth CW, Ketz JP, Mooney RA, Hilton MJ, Jonason JH, Prawitt J, Zuscik MJ.

PLoS One. 2017 Apr 6;12(4):e0174705. doi: 10.1371/journal.pone.0174705. eCollection 2017.


Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence.

Farnsworth CW, Schott EM, Jensen SE, Zukoski J, Benvie AM, Refaai MA, Kates SL, Schwarz EM, Zuscik MJ, Gill SR, Mooney RA.

Infect Immun. 2017 May 23;85(6). pii: e01005-16. doi: 10.1128/IAI.01005-16. Print 2017 Jun.


Extraction of high-quality RNA from human articular cartilage.

Le Bleu HK, Kamal FA, Kelly M, Ketz JP, Zuscik MJ, Elbarbary RA.

Anal Biochem. 2017 Feb 1;518:134-138. doi: 10.1016/j.ab.2016.11.018. Epub 2016 Nov 29.


Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus.

Hamada D, Maynard R, Schott E, Drinkwater CJ, Ketz JP, Kates SL, Jonason JH, Hilton MJ, Zuscik MJ, Mooney RA.

Arthritis Rheumatol. 2016 Jun;68(6):1392-402. doi: 10.1002/art.39561.


Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Bone Res. 2015 Aug 11;3:15021. doi: 10.1038/boneres.2015.21. eCollection 2015.


Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Osteoarthritis Cartilage. 2016 Apr;24(4):740-51. doi: 10.1016/j.joca.2015.10.015. Epub 2015 Oct 30.


CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ.

J Bone Miner Res. 2016 Mar;31(3):549-59. doi: 10.1002/jbmr.2712.


A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792.


A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes.

Farnsworth CW, Shehatou CT, Maynard R, Nishitani K, Kates SL, Zuscik MJ, Schwarz EM, Daiss JL, Mooney RA.

Infect Immun. 2015 Jun;83(6):2264-74. doi: 10.1128/IAI.03074-14. Epub 2015 Mar 23.


High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment.

Shu L, Beier E, Sheu T, Zhang H, Zuscik MJ, Puzas EJ, Boyce BF, Mooney RA, Xing L.

Calcif Tissue Int. 2015 Apr;96(4):313-23. doi: 10.1007/s00223-015-9954-z. Epub 2015 Feb 13.


Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

Sheu TJ, Zhou W, Fan J, Zhou H, Zuscik MJ, Xie C, Yin G, Berk BC.

Mol Cell Biochem. 2014 Dec;397(1-2):67-74. doi: 10.1007/s11010-014-2173-5. Epub 2014 Aug 20.


Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing.

Beier EE, Sheu TJ, Buckley T, Yukata K, O'Keefe R, Zuscik MJ, Puzas JE.

J Orthop Res. 2014 Nov;32(11):1397-405. doi: 10.1002/jor.22677. Epub 2014 Jul 21.


Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ.

PLoS One. 2014 Jun 9;9(6):e99656. doi: 10.1371/journal.pone.0099656. eCollection 2014.


Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes.

David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA.

PLoS One. 2014 Mar 21;9(3):e91234. doi: 10.1371/journal.pone.0091234. eCollection 2014.


Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC.

PLoS One. 2014 Feb 19;9(2):e89127. doi: 10.1371/journal.pone.0089127. eCollection 2014.


Surgical induction of posttraumatic osteoarthritis in the mouse.

Hamada D, Sampson ER, Maynard RD, Zuscik MJ.

Methods Mol Biol. 2014;1130:61-72. doi: 10.1007/978-1-62703-989-5_5.


TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH.

J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. doi: 10.1242/jcs.135483. Epub 2013 Oct 21.


Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur.

Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA.

Bone. 2013 Nov;57(1):174-83. doi: 10.1016/j.bone.2013.08.003. Epub 2013 Aug 14.


RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ.

Arthritis Rheum. 2013 Oct;65(10):2623-33. doi: 10.1002/art.38076.


Engineering superficial zone features in tissue engineered cartilage.

Chen T, Hilton MJ, Brown EB, Zuscik MJ, Awad HA.

Biotechnol Bioeng. 2013 May;110(5):1476-86. doi: 10.1002/bit.24799. Epub 2012 Dec 27.


Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling.

Beier EE, Maher JR, Sheu TJ, Cory-Slechta DA, Berger AJ, Zuscik MJ, Puzas JE.

Environ Health Perspect. 2013 Jan;121(1):97-104. doi: 10.1289/ehp.1205374. Epub 2012 Oct 19. Erratum in: Environ Health Perspect. 2013 Feb;121(2):a43.


PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM.

J Bone Miner Res. 2013 Mar;28(3):586-97. doi: 10.1002/jbmr.1765.


Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.

Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ.

J Cell Biochem. 2012 Jun;113(6):2156-66. doi: 10.1002/jcb.24089.


Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D.

Arthritis Rheum. 2012 Aug;64(8):2611-23. doi: 10.1002/art.34469.


Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Development. 2012 Mar;139(6):1198-212. doi: 10.1242/dev.070649.


High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury.

Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ.

Arthritis Res Ther. 2011;13(6):R198. doi: 10.1186/ar3529. Epub 2011 Dec 7.


Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ.

Sci Transl Med. 2011 Sep 21;3(101):101ra93. doi: 10.1126/scitranslmed.3002214.


Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene.

Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ.

J Cell Physiol. 2012 Mar;227(3):1062-70. doi: 10.1002/jcp.22819.


Smad1 plays an essential role in bone development and postnatal bone formation.

Wang M, Jin H, Tang D, Huang S, Zuscik MJ, Chen D.

Osteoarthritis Cartilage. 2011 Jun;19(6):751-62. doi: 10.1016/j.joca.2011.03.004. Epub 2011 Mar 21.


Establishment of an index with increased sensitivity for assessing murine arthritis.

Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ.

J Orthop Res. 2011 Aug;29(8):1145-51. doi: 10.1002/jor.21368. Epub 2011 Mar 3.


Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects.

Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA.

Tissue Eng Part A. 2011 Feb;17(3-4):389-98. doi: 10.1089/ten.TEA.2010.0115. Epub 2010 Oct 29.


Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering.

Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA.

J Biomed Mater Res A. 2010 Dec 1;95(3):717-26. doi: 10.1002/jbm.a.32868.


GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC.

J Cell Physiol. 2010 Nov;225(3):777-85. doi: 10.1002/jcp.22282.


Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ.

Arthritis Rheum. 2010 Aug;62(8):2359-69. doi: 10.1002/art.27537.


Beta-catenin, cartilage, and osteoarthritis.

Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D.

Ann N Y Acad Sci. 2010 Mar;1192:344-50. doi: 10.1111/j.1749-6632.2009.05212.x. Review.


RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Development. 2010 May;137(9):1461-71. doi: 10.1242/dev.042911. Epub 2010 Mar 24.


Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN.

Exp Cell Res. 2009 Aug 15;315(14):2386-98. doi: 10.1016/j.yexcr.2009.05.019. Epub 2009 May 27.


Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.

Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ.

J Orthop Res. 2009 Jun;27(6):785-92. doi: 10.1002/jor.20805.


Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ.

J Bone Miner Res. 2009 Feb;24(2):251-64. doi: 10.1359/jbmr.081002.


Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN.

Arthritis Rheum. 2008 Oct;58(10):3132-44. doi: 10.1002/art.23946.


Erythropoietin accelerates functional recovery after peripheral nerve injury.

Elfar JC, Jacobson JA, Puzas JE, Rosier RN, Zuscik MJ.

J Bone Joint Surg Am. 2008 Aug;90(8):1644-53. doi: 10.2106/JBJS.G.00557.


Regulation of chondrogenesis and chondrocyte differentiation by stress.

Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ.

J Clin Invest. 2008 Feb;118(2):429-38. doi: 10.1172/JCI34174. Review.


Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH.

Oncogene. 2008 Jun 5;27(25):3605-14. doi: 10.1038/sj.onc.1211020. Epub 2008 Jan 28.


Regulation of embryonic endochondral ossification by Smurf2.

Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN.

J Orthop Res. 2008 May;26(5):704-12. doi: 10.1002/jor.20563.


Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.

Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN.

J Bone Miner Res. 2008 Apr;23(4):552-63.


Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations.

Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ.

Environ Health Perspect. 2007 Sep;115(9):1276-82.


Environmental agents affect skeletal growth and development.

Holz JD, Sheu TJ, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE.

Birth Defects Res C Embryo Today. 2007 Mar;81(1):41-50. Review.


Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.

Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.

J Bone Miner Res. 2007 Aug;22(8):1260-70.

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