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Items: 10


The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.

Maik-Rachline G, Zehorai E, Hanoch T, Blenis J, Seger R.

Sci Signal. 2018 Apr 10;11(525). pii: eaao3428. doi: 10.1126/scisignal.aao3428.


Correction for Zehorai and Seger, "Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases".

Zehorai E, Seger R.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00215-17. doi: 10.1128/MCB.00215-17. Print 2017 Aug 15. No abstract available.


Distinct biological events generated by ECM proteolysis by two homologous collagenases.

Solomonov I, Zehorai E, Talmi-Frank D, Wolf SG, Shainskaya A, Zhuravlev A, Kartvelishvily E, Visse R, Levin Y, Kampf N, Jaitin DA, David E, Amit I, Nagase H, Sagi I.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10884-9. doi: 10.1073/pnas.1519676113. Epub 2016 Sep 14.


The nuclear translocation of ERK1/2 as an anticancer target.

Plotnikov A, Flores K, Maik-Rachline G, Zehorai E, Kapri-Pardes E, Berti DA, Hanoch T, Besser MJ, Seger R.

Nat Commun. 2015 Mar 30;6:6685. doi: 10.1038/ncomms7685.


Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo.

Gaffney J, Solomonov I, Zehorai E, Sagi I.

Matrix Biol. 2015 May-Jul;44-46:191-9. doi: 10.1016/j.matbio.2015.01.012. Epub 2015 Jan 24. Review.


Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.

Maimon A, Mogilevsky M, Shilo A, Golan-Gerstl R, Obiedat A, Ben-Hur V, Lebenthal-Loinger I, Stein I, Reich R, Beenstock J, Zehorai E, Andersen CL, Thorsen K, Orntoft TF, Davis RJ, Davidson B, Mu D, Karni R.

Cell Rep. 2014 Apr 24;7(2):501-13. doi: 10.1016/j.celrep.2014.03.041. Epub 2014 Apr 13.


Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases.

Zehorai E, Seger R.

Mol Cell Biol. 2014 Jan;34(2):259-70. doi: 10.1128/MCB.00799-13. Epub 2013 Nov 11. Erratum in: Mol Cell Biol. 2017 Jul 28;37(16):.


The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.

Plotnikov A, Zehorai E, Procaccia S, Seger R.

Biochim Biophys Acta. 2011 Sep;1813(9):1619-33. doi: 10.1016/j.bbamcr.2010.12.012. Epub 2010 Dec 16. Review.


The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus.

Zehorai E, Yao Z, Plotnikov A, Seger R.

Mol Cell Endocrinol. 2010 Jan 27;314(2):213-20. doi: 10.1016/j.mce.2009.04.008. Epub 2009 May 4. Review.


Glutamate regulates the activity of topoisomerase I in mouse cerebellum.

Zehorai E, Eitan E, Hershfinkel M, Sekler I, Priel E.

Mol Neurobiol. 2008 Dec;38(3):242-52. doi: 10.1007/s12035-008-8044-x. Epub 2008 Nov 4.


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