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Items: 24

1.

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B.

Biochemistry. 2014 Dec 16;53(49):7854-65. doi: 10.1021/bi501396v. Epub 2014 Dec 1.

2.

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B.

J Biol Chem. 2009 Oct 23;284(43):29746-56. doi: 10.1074/jbc.M109.046805. Epub 2009 Sep 2.

3.

TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).

Banskota AH, Aouidate M, Sørensen D, Ibrahim A, Piraee M, Zazopoulos E, Alarco AM, Gourdeau H, Mellon C, Farnet CM, Falardeau P, McAlpine JB.

J Antibiot (Tokyo). 2009 Oct;62(10):565-70. doi: 10.1038/ja.2009.77. Epub 2009 Aug 14.

PMID:
19680283
4.

Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system.

McAlpine JB, Banskota AH, Charan RD, Schlingmann G, Zazopoulos E, Piraee M, Janso J, Bernan VS, Aouidate M, Farnet CM, Feng X, Zhao Z, Carter GT.

J Nat Prod. 2008 Sep;71(9):1585-90. doi: 10.1021/np800376n. Epub 2008 Aug 23.

PMID:
18722414
5.

Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes.

Hu Y, Phelan VV, Farnet CM, Zazopoulos E, Bachmann BO.

Chembiochem. 2008 Jul 2;9(10):1603-8. doi: 10.1002/cbic.200800029.

PMID:
18512205
6.

Benzodiazepine biosynthesis in Streptomyces refuineus.

Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO.

Chem Biol. 2007 Jun;14(6):691-701. Erratum in: Chem Biol. 2007 Jul;14(7):870.

7.

Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster.

Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore BS.

J Biol Chem. 2007 Jun 1;282(22):16362-8. Epub 2007 Mar 28.

8.

Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.

Banskota AH, Mcalpine JB, Sørensen D, Ibrahim A, Aouidate M, Piraee M, Alarco AM, Farnet CM, Zazopoulos E.

J Antibiot (Tokyo). 2006 Sep;59(9):533-42.

PMID:
17136886
9.

Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.

Banskota AH, Mcalpine JB, Sørensen D, Aouidate M, Piraee M, Alarco AM, Omura S, Shiomi K, Farnet CM, Zazopoulos E.

J Antibiot (Tokyo). 2006 Mar;59(3):168-76.

PMID:
16724457
10.

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

McAlpine JB, Bachmann BO, Piraee M, Tremblay S, Alarco AM, Zazopoulos E, Farnet CM.

J Nat Prod. 2005 Apr;68(4):493-6.

PMID:
15844935
11.

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B.

Chem Biol. 2005 Mar;12(3):293-302.

12.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM.

Nat Biotechnol. 2003 Feb;21(2):187-90. Epub 2003 Jan 21.

PMID:
12536216
13.

The calicheamicin gene cluster and its iterative type I enediyne PKS.

Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS.

Science. 2002 Aug 16;297(5584):1173-6.

14.

A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita.

Lalli E, Bardoni B, Zazopoulos E, Wurtz JM, Strom TM, Moras D, Sassone-Corsi P.

Mol Endocrinol. 1997 Dec;11(13):1950-60.

PMID:
9415399
15.

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis.

Zazopoulos E, Lalli E, Stocco DM, Sassone-Corsi P.

Nature. 1997 Nov 20;390(6657):311-5.

PMID:
9384387
16.

Coupling transcription to signaling pathways: cAMP and nuclear factor cAMP-responsive element modulator.

Monaco L, Lamas M, Tamai K, Lalli E, Zazopoulos E, Penna L, Nantel F, Foulkes NS, Mazzucchelli C, Sassone-Corsi P.

Adv Second Messenger Phosphoprotein Res. 1997;31:63-74. Review. No abstract available.

PMID:
9344242
17.

Coupling signalling pathways to transcriptional control: nuclear factors responsive to cAMP.

Tamai KT, Monaco L, Nantel F, Zazopoulos E, Sassone-Corsi P.

Recent Prog Horm Res. 1997;52:121-39; discussion 139-40. Review.

PMID:
9238850
18.

CREM: a master-switch in the transcriptional response to cAMP.

Lamas M, Monaco L, Zazopoulos E, Lalli E, Tamai K, Penna L, Mazzucchelli C, Nantel F, Foulkes NS, Sassone-Corsi P.

Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29;351(1339):561-7. Review.

PMID:
8735279
19.

The nuclear response to cAMP: role of transcription factor CREM.

Lalli E, Lee JS, Lamas M, Tamai K, Zazopoulos E, Nantel F, Penna L, Foulkes NS, Sassone-Corsi P.

Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):201-9. Review.

PMID:
8650267
20.

Effect of nef alleles on replication of human immunodeficiency virus type 1.

Zazopoulos E, Haseltine WA.

Virology. 1993 May;194(1):20-7.

PMID:
7683154
21.
22.

Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function.

Zazopoulos E, Haseltine WA.

Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6634-8.

23.

Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.

Terwilliger EF, Langhoff E, Gabuzda D, Zazopoulos E, Haseltine WA.

Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10971-5.

24.

p21rex protein of HTLV-1.

Zazopoulos E, Sodroski JG, Haseltine WA.

J Acquir Immune Defic Syndr. 1990;3(12):1135-9.

PMID:
2243315

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