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Items: 1 to 50 of 204

1.

Ruth S. Nussenzweig (1928-2018).

Seder RA, Zavala F.

Nature. 2018 May;557(7705):310. doi: 10.1038/d41586-018-05102-3. No abstract available.

PMID:
29752450
2.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19.

PMID:
29554083
3.

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.

Oyen D, Torres JL, Wille-Reece U, Ockenhouse CF, Emerling D, Glanville J, Volkmuth W, Flores-Garcia Y, Zavala F, Ward AB, King CR, Wilson IA.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10438-E10445. doi: 10.1073/pnas.1715812114. Epub 2017 Nov 14.

4.

Robust antibody and CD8+ T-cell responses induced by P. falciparum CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against experimental rodent malaria infection.

Espinosa DA, Christensen D, Muñoz C, Singh S, Locke E, Andersen P, Zavala F.

NPJ Vaccines. 2017;2. pii: 10. doi: 10.1038/s41541-017-0011-y. Epub 2017 Apr 10.

5.

Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus.

Urakami A, Sakurai A, Ishikawa M, Yap ML, Flores-Garcia Y, Haseda Y, Aoshi T, Zavala FP, Rossmann MG, Kuno S, Ueno R, Akahata W.

Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00090-17. doi: 10.1128/CVI.00090-17. Print 2017 Jul.

6.

Immune Responses in Malaria.

Long CA, Zavala F.

Cold Spring Harb Perspect Med. 2017 Aug 1;7(8). pii: a025577. doi: 10.1101/cshperspect.a025577. Review.

PMID:
28389518
7.

Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine.

Luo K, Zavala F, Gordy J, Zhang H, Markham RB.

Vaccine. 2017 Apr 25;35(18):2358-2364. doi: 10.1016/j.vaccine.2017.03.052. Epub 2017 Mar 23.

PMID:
28342669
8.

A Prime/Boost PfCS14KM/MVA-sPfCSM Vaccination Protocol Generates Robust CD8+ T Cell and Antibody Responses to Plasmodium falciparum Circumsporozoite Protein and Protects Mice against Malaria.

Vijayan A, Mejías-Pérez E, Espinosa DA, Raman SC, Sorzano COS, Zavala F, Esteban M.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00494-16. doi: 10.1128/CVI.00494-16. Print 2017 May.

9.

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.

Aguiar AC, Figueiredo FJ, Neuenfeldt PD, Katsuragawa TH, Drawanz BB, Cunico W, Sinnis P, Zavala F, Krettli AU.

Malar J. 2017 Mar 9;16(1):110. doi: 10.1186/s12936-017-1755-6.

10.

The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines.

Espinosa DA, Vega-Rodriguez J, Flores-Garcia Y, Noe AR, Muñoz C, Coleman R, Bruck T, Haney K, Stevens A, Retallack D, Allen J, Vedvick TS, Fox CB, Reed SG, Howard RF, Salman AM, Janse CJ, Khan SM, Zavala F, Gutierrez GM.

Infect Immun. 2017 Jan 26;85(2). pii: e00498-16. doi: 10.1128/IAI.00498-16. Print 2017 Feb.

11.

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.

Korniotis S, Gras C, Letscher H, Montandon R, Mégret J, Siegert S, Ezine S, Fallon PG, Luther SA, Fillatreau S, Zavala F.

Nat Commun. 2016 Jul 11;7:12134. doi: 10.1038/ncomms12134.

12.

Malaria vaccines and human immune responses.

Long CA, Zavala F.

Curr Opin Microbiol. 2016 Aug;32:96-102. doi: 10.1016/j.mib.2016.04.006. Epub 2016 Jun 2. Review.

13.

Development and Assessment of Transgenic Rodent Parasites for the Preclinical Evaluation of Malaria Vaccines.

Espinosa DA, Radtke AJ, Zavala F.

Methods Mol Biol. 2016;1403:583-601. doi: 10.1007/978-1-4939-3387-7_33.

PMID:
27076155
14.

Dendritic cell function and antigen presentation in malaria.

Cockburn IA, Zavala F.

Curr Opin Immunol. 2016 Jun;40:1-6. doi: 10.1016/j.coi.2016.01.010. Epub 2016 Feb 1. Review.

PMID:
26845735
15.

Characterization and Immunoregulatory Properties of Innate Pro-B-Cell Progenitors.

Zavala F, Korniotis S, Montandon R.

Methods Mol Biol. 2016;1371:79-88. doi: 10.1007/978-1-4939-3139-2_5. Review.

PMID:
26530795
16.

Lymphoid Gene Upregulation on Circulating Progenitors Participates in Their T-Lineage Commitment.

Zepponi V, Michaels Lopez V, Martinez-Cingolani C, Boudil A, Pasqualetto V, Skhiri L, Gautreau L, Legrand A, Megret J, Zavala F, Ezine S.

J Immunol. 2015 Jul 1;195(1):156-65. doi: 10.4049/jimmunol.1403219. Epub 2015 May 29.

17.

P. falciparum and P. vivax Epitope-Focused VLPs Elicit Sterile Immunity to Blood Stage Infections.

Whitacre DC, Espinosa DA, Peters CJ, Jones JE, Tucker AE, Peterson DL, Zavala FP, Milich DR.

PLoS One. 2015 May 1;10(5):e0124856. doi: 10.1371/journal.pone.0124856. eCollection 2015.

18.

From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.

Radtke AJ, Tse SW, Zavala F.

Semin Immunopathol. 2015 May;37(3):211-20. doi: 10.1007/s00281-015-0479-3. Epub 2015 Apr 28. Review.

19.

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria.

Bijker EM, Nganou-Makamdop K, van Gemert GJ, Zavala F, Cockburn I, Sauerwein RW.

Malar J. 2015 Mar 26;14:130. doi: 10.1186/s12936-015-0626-2.

20.

G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.

D'Aveni M, Rossignol J, Coman T, Sivakumaran S, Henderson S, Manzo T, Santos e Sousa P, Bruneau J, Fouquet G, Zavala F, Alegria-Prévot O, Garfa-Traoré M, Suarez F, Trebeden-Nègre H, Mohty M, Bennett CL, Chakraverty R, Hermine O, Rubio MT.

Sci Transl Med. 2015 Apr 1;7(281):281ra42. doi: 10.1126/scitranslmed.3010435.

PMID:
25834108
21.

Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies.

Espinosa DA, Gutierrez GM, Rojas-López M, Noe AR, Shi L, Tse SW, Sinnis P, Zavala F.

J Infect Dis. 2015 Oct 1;212(7):1111-9. doi: 10.1093/infdis/jiv154. Epub 2015 Mar 11.

22.

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.

Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP, Cockburn IA.

PLoS Pathog. 2015 Feb 6;11(2):e1004637. doi: 10.1371/journal.ppat.1004637. eCollection 2015 Feb.

23.

A replicating adenovirus capsid display recombinant elicits antibodies against Plasmodium falciparum sporozoites in Aotus nancymaae monkeys.

Karen KA, Deal C, Adams RJ, Nielsen C, Ward C, Espinosa DA, Xie J, Zavala F, Ketner G.

Infect Immun. 2015 Jan;83(1):268-75. doi: 10.1128/IAI.02626-14. Epub 2014 Nov 3.

24.

A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate.

Noe AR, Espinosa D, Li X, Coelho-Dos-Reis JG, Funakoshi R, Giardina S, Jin H, Retallack DM, Haverstock R, Allen JR, Vedvick TS, Fox CB, Reed SG, Ayala R, Roberts B, Winram SB, Sacci J, Tsuji M, Zavala F, Gutierrez GM.

PLoS One. 2014 Sep 23;9(9):e107764. doi: 10.1371/journal.pone.0107764. eCollection 2014.

25.

Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice.

Deal C, Balazs AB, Espinosa DA, Zavala F, Baltimore D, Ketner G.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12528-32. doi: 10.1073/pnas.1407362111. Epub 2014 Aug 11.

26.

The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8⁺ T cells specific for infectious pathogens.

Tse SW, Radtke AJ, Espinosa DA, Cockburn IA, Zavala F.

J Infect Dis. 2014 Nov 1;210(9):1508-16. doi: 10.1093/infdis/jiu281. Epub 2014 May 13.

27.

Fusion of antigen to a dendritic cell targeting chemokine combined with adjuvant yields a malaria DNA vaccine with enhanced protective capabilities.

Luo K, Zhang H, Zavala F, Biragyn A, Espinosa DA, Markham RB.

PLoS One. 2014 Mar 5;9(3):e90413. doi: 10.1371/journal.pone.0090413. eCollection 2014.

28.

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.

Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH.

Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9.

29.

CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect.

Cockburn IA, Tse SW, Zavala F.

Infect Immun. 2014 Apr;82(4):1460-4. doi: 10.1128/IAI.01500-13. Epub 2014 Jan 13.

30.

Looking under the skin: the first steps in malarial infection and immunity.

Ménard R, Tavares J, Cockburn I, Markus M, Zavala F, Amino R.

Nat Rev Microbiol. 2013 Oct;11(10):701-12. doi: 10.1038/nrmicro3111. Review.

PMID:
24037451
31.

CCL22-producing CD8α- myeloid dendritic cells mediate regulatory T cell recruitment in response to G-CSF treatment.

Layseca-Espinosa E, Korniotis S, Montandon R, Gras C, Bouillié M, Gonzalez-Amaro R, Dy M, Zavala F.

J Immunol. 2013 Sep 1;191(5):2266-72. doi: 10.4049/jimmunol.1202307. Epub 2013 Jul 22.

32.

Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells.

Montandon R, Korniotis S, Layseca-Espinosa E, Gras C, Mégret J, Ezine S, Dy M, Zavala F.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2199-208. doi: 10.1073/pnas.1222446110. Epub 2013 May 28.

33.

Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy.

Espinosa DA, Yadava A, Angov E, Maurizio PL, Ockenhouse CF, Zavala F.

Infect Immun. 2013 Aug;81(8):2882-7. doi: 10.1128/IAI.00461-13. Epub 2013 May 28.

34.

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.

Cockburn IA, Amino R, Kelemen RK, Kuo SC, Tse SW, Radtke A, Mac-Daniel L, Ganusov VV, Zavala F, Ménard R.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9090-5. doi: 10.1073/pnas.1303858110. Epub 2013 May 14.

35.

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites.

Tse SW, Cockburn IA, Zhang H, Scott AL, Zavala F.

Genes Immun. 2013 Jul-Aug;14(5):302-9. doi: 10.1038/gene.2013.20. Epub 2013 Apr 18.

36.

Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mice.

Kastenmüller K, Espinosa DA, Trager L, Stoyanov C, Salazar AM, Pokalwar S, Singh S, Dutta S, Ockenhouse CF, Zavala F, Seder RA.

Infect Immun. 2013 Mar;81(3):789-800. doi: 10.1128/IAI.01108-12. Epub 2012 Dec 28.

37.

The skin: where malaria infection and the host immune response begin.

Sinnis P, Zavala F.

Semin Immunopathol. 2012 Nov;34(6):787-92. doi: 10.1007/s00281-012-0345-5. Epub 2012 Oct 2. Review.

38.

Development and use of TCR transgenic mice for malaria immunology research.

Chen YC, Zavala F.

Methods Mol Biol. 2013;923:481-91.

PMID:
22990799
39.

Adjuvant-like effect of vaccinia virus 14K protein: a case study with malaria vaccine based on the circumsporozoite protein.

Vijayan A, Gómez CE, Espinosa DA, Goodman AG, Sanchez-Sampedro L, Sorzano CO, Zavala F, Esteban M.

J Immunol. 2012 Jun 15;188(12):6407-17. doi: 10.4049/jimmunol.1102492. Epub 2012 May 21.

40.

Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development.

Tse SW, Radtke AJ, Zavala F.

Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:172-8. Review.

41.

Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo.

Cockburn IA, Tse SW, Radtke AJ, Srinivasan P, Chen YC, Sinnis P, Zavala F.

PLoS Pathog. 2011 Mar;7(3):e1001318. doi: 10.1371/journal.ppat.1001318. Epub 2011 Mar 17.

42.

CD4+ T cells modulate expansion and survival but not functional properties of effector and memory CD8+ T cells induced by malaria sporozoites.

Overstreet MG, Chen YC, Cockburn IA, Tse SW, Zavala F.

PLoS One. 2011 Jan 4;6(1):e15948. doi: 10.1371/journal.pone.0015948.

43.

Adenovirus particles that display the Plasmodium falciparum circumsporozoite protein NANP repeat induce sporozoite-neutralizing antibodies in mice.

Palma C, Overstreet MG, Guedon JM, Hoiczyk E, Ward C, Karen KA, Zavala F, Ketner G.

Vaccine. 2011 Feb 11;29(8):1683-9. doi: 10.1016/j.vaccine.2010.12.040. Epub 2011 Jan 1.

44.

Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites.

Cockburn IA, Chen YC, Overstreet MG, Lees JR, van Rooijen N, Farber DL, Zavala F.

PLoS Pathog. 2010 May 6;6(5):e1000877. doi: 10.1371/journal.ppat.1000877.

45.

Neuropathogenesis of human and murine malaria.

Riley EM, Couper KN, Helmby H, Hafalla JC, de Souza JB, Langhorne J, Jarra WB, Zavala F.

Trends Parasitol. 2010 Jun;26(6):277-8. doi: 10.1016/j.pt.2010.03.002. Epub 2010 Mar 24. No abstract available.

PMID:
20338809
46.

Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice.

Noland GS, Chowdhury DR, Urban JF Jr, Zavala F, Kumar N.

Vaccine. 2010 Apr 9;28(17):2917-23. doi: 10.1016/j.vaccine.2010.02.055. Epub 2010 Feb 25.

47.

CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells.

Overstreet MG, Freyberger H, Cockburn IA, Chen YC, Tse SW, Zavala F.

Eur J Immunol. 2010 Jan;40(1):124-33. doi: 10.1002/eji.200939493.

48.

Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response.

Overstreet MG, Cockburn IA, Chen YC, Zavala F.

Immunol Rev. 2008 Oct;225:272-83. doi: 10.1111/j.1600-065X.2008.00671.x. Review.

49.

Anergy in memory CD4+ T cells is induced by B cells.

Dalai SK, Mirshahidi S, Morrot A, Zavala F, Sadegh-Nasseri S.

J Immunol. 2008 Sep 1;181(5):3221-31.

50.

Platelet factor 4 mediates inflammation in experimental cerebral malaria.

Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, Sullivan D, Zavala F, Morrell CN.

Cell Host Microbe. 2008 Aug 14;4(2):179-87. doi: 10.1016/j.chom.2008.07.003.

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