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Regulation of autoimmune and anti-tumour T cell responses by PTPN22.

Brownlie RJ, Zamoyska R, Salmond RJ.

Immunology. 2018 Mar 7. doi: 10.1111/imm.12919. [Epub ahead of print] Review.


Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.

Brownlie RJ, Garcia C, Ravasz M, Zehn D, Salmond RJ, Zamoyska R.

Nat Commun. 2017 Nov 7;8(1):1343. doi: 10.1038/s41467-017-01427-1.


Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

Clarke F, Jordan CK, Gutiérrez-Martinez E, Bibby JA, Sanchez-Blanco C, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP, Purvis HA.

PLoS One. 2017 Oct 17;12(10):e0186625. doi: 10.1371/journal.pone.0186625. eCollection 2017.


Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

Purvis HA, Clarke F, Jordan CK, Blanco CS, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Cope AP.

Eur J Immunol. 2018 Feb;48(2):306-315. doi: 10.1002/eji.201747092. Epub 2017 Oct 20.


Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells.

Tan TCJ, Knight J, Sbarrato T, Dudek K, Willis AE, Zamoyska R.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6117-E6126. doi: 10.1073/pnas.1700939114. Epub 2017 Jul 10.


Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells.

Borger JG, Morrison VL, Filby A, Garcia C, Uotila LM, Simbari F, Fagerholm SC, Zamoyska R.

J Immunol. 2017 Aug 1;199(3):874-884. doi: 10.4049/jimmunol.1700431. Epub 2017 Jun 21.


Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with overwinter survival.

Watson RL, McNeilly TN, Watt KA, Pemberton JM, Pilkington JG, Waterfall M, Hopper PR, Cooney D, Zamoyska R, Nussey DH.

Ecol Evol. 2016 Nov 15;6(24):8695-8705. doi: 10.1002/ece3.2584. eCollection 2016 Dec.


PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.

Vermeren S, Miles K, Chu JY, Salter D, Zamoyska R, Gray M.

J Immunol. 2016 Dec 15;197(12):4771-4779. Epub 2016 Nov 2.


Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.

Burn GL, Cornish GH, Potrzebowska K, Samuelsson M, Griffié J, Minoughan S, Yates M, Ashdown G, Pernodet N, Morrison VL, Sanchez-Blanco C, Purvis H, Clarke F, Brownlie RJ, Vyse TJ, Zamoyska R, Owen DM, Svensson LM, Cope AP.

Sci Signal. 2016 Oct 4;9(448):ra99.


IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.

Goplen NP, Saxena V, Knudson KM, Schrum AG, Gil D, Daniels MA, Zamoyska R, Teixeiro E.

J Immunol. 2016 Sep 15;197(6):2434-43. doi: 10.4049/jimmunol.1600037. Epub 2016 Aug 12.


Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.

Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R.

J Immunol. 2016 Jul 15;197(2):429-40. doi: 10.4049/jimmunol.1502656. Epub 2016 Jun 10.


Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.

Salmond RJ, Brownlie RJ, Meyuhas O, Zamoyska R.

J Immunol. 2015 Nov 15;195(10):4615-22. doi: 10.4049/jimmunol.1501473. Epub 2015 Oct 9.


Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.

Salmond RJ, Brownlie RJ, Zamoyska R.

Cell Cycle. 2015;14(5):705-11. doi: 10.1080/15384101.2015.1007018.


Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR.

Nat Commun. 2014 Nov 27;5:5624. doi: 10.1038/ncomms6624.


The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.

Salmond RJ, Brownlie RJ, Morrison VL, Zamoyska R.

Nat Immunol. 2014 Sep;15(9):875-883. doi: 10.1038/ni.2958. Epub 2014 Aug 10.


Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells.

Borger JG, Zamoyska R, Gakamsky DM.

Immunol Lett. 2014 Jan-Feb;157(1-2):16-22. doi: 10.1016/j.imlet.2013.11.005. Epub 2013 Nov 18.


T cell receptor signalling networks: branched, diversified and bounded.

Brownlie RJ, Zamoyska R.

Nat Rev Immunol. 2013 Apr;13(4):257-69. doi: 10.1038/nri3403. Review.


Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.

Borger JG, Filby A, Zamoyska R.

J Immunol. 2013 Apr 1;190(7):3089-99. doi: 10.4049/jimmunol.1202408. Epub 2013 Feb 20.


Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

Caserta S, Borger JG, Zamoyska R.

Crit Rev Immunol. 2012;32(2):97-126. Review.


Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

Brownlie RJ, Miosge LA, Vassilakos D, Svensson LM, Cope A, Zamoyska R.

Sci Signal. 2012 Nov 27;5(252):ra87. doi: 10.1126/scisignal.2003365.


Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R.

PLoS One. 2012;7(4):e35466. doi: 10.1371/journal.pone.0035466. Epub 2012 Apr 9.


Age-related variation in immunity in a wild mammal population.

Nussey DH, Watt K, Pilkington JG, Zamoyska R, McNeilly TN.

Aging Cell. 2012 Feb;11(1):178-80. doi: 10.1111/j.1474-9726.2011.00771.x. Epub 2011 Dec 28.


Novel strategy for microsphere-mediated DNA transfection.

Borger JG, Cardenas-Maestre JM, Zamoyska R, Sanchez-Martin RM.

Bioconjug Chem. 2011 Oct 19;22(10):1904-8. doi: 10.1021/bc200289n. Epub 2011 Sep 15.


The influence of mTOR on T helper cell differentiation and dendritic cell function.

Salmond RJ, Zamoyska R.

Eur J Immunol. 2011 Aug;41(8):2137-41. doi: 10.1002/eji.201141523. Epub 2011 Jul 4. Review.


Centrosome docking at the immunological synapse is controlled by Lck signaling.

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.

J Cell Biol. 2011 Feb 21;192(4):663-74. doi: 10.1083/jcb.201008140.


Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.

Caserta S, Kleczkowska J, Mondino A, Zamoyska R.

J Immunol. 2010 Dec 1;185(11):6545-54. doi: 10.4049/jimmunol.1001867. Epub 2010 Nov 3.


Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.

Salmond RJ, Filby A, Pirinen N, Magee AI, Zamoyska R.

Blood. 2011 Jan 6;117(1):108-17. doi: 10.1182/blood-2010-03-277160. Epub 2010 Sep 28.


How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation?

Salmond RJ, Zamoyska R.

Cell Cycle. 2010 Aug 1;9(15):2952-7. doi: 10.4161/cc.9.15.12358. Epub 2010 Aug 12.


MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.

Salmond RJ, Emery J, Okkenhaug K, Zamoyska R.

J Immunol. 2009 Dec 1;183(11):7388-97. doi: 10.4049/jimmunol.0902294. Epub 2009 Nov 16.


LAT polices T cell activation.

Brownlie R, Zamoyska R.

Immunity. 2009 Aug 21;31(2):174-6. doi: 10.1016/j.immuni.2009.08.002.


The Global Thymus Network: past, present and future.

Takahama Y, Saito T, Kawamoto H, Itoi M, Boyd RL, Chidgey A, Zamoyska R, Holländer GA, Anderson G, Taylor N, Petrie HT, Nikolich-Zugich J.

Trends Immunol. 2009 May;30(5):191-2. doi: 10.1016/ Epub 2009 Apr 8. No abstract available.


T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.

Salmond RJ, Filby A, Qureshi I, Caserta S, Zamoyska R.

Immunol Rev. 2009 Mar;228(1):9-22. doi: 10.1111/j.1600-065X.2008.00745.x. Review.


An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.

Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, Kioussis D, Zamoyska R.

J Immunol. 2009 Jan 1;182(1):121-9.


Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice.

Parravicini V, Field AC, Tomlinson PD, Basson MA, Zamoyska R.

Blood. 2008 Apr 15;111(8):4273-7282. doi: 10.1182/blood-2007-10-115667. Epub 2008 Feb 6.


Why is there so much CD45 on T cells?

Zamoyska R.

Immunity. 2007 Sep;27(3):421-3. Review.


Fyn regulates the duration of TCR engagement needed for commitment to effector function.

Filby A, Seddon B, Kleczkowska J, Salmond R, Tomlinson P, Smida M, Lindquist JA, Schraven B, Zamoyska R.

J Immunol. 2007 Oct 1;179(7):4635-44.


CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.

McNicol AM, Bendle G, Holler A, Matjeka T, Dalton E, Rettig L, Zamoyska R, Uckert W, Xue SA, Stauss HJ.

Eur J Immunol. 2007 Jun;37(6):1634-41.


Memories are made of this: synergy of T cell receptor and cytokine signals in CD4(+) central memory cell survival.

Caserta S, Zamoyska R.

Trends Immunol. 2007 Jun;28(6):245-8. Epub 2007 Apr 25. Review.


Signalling in T-cell development: is it all location, location, location?

Miosge L, Zamoyska R.

Curr Opin Immunol. 2007 Apr;19(2):194-9. Epub 2007 Feb 15. Review.


Superantigens: supersignalers?

Zamoyska R.

Sci STKE. 2006 Oct 24;2006(358):pe45. Review.


Differential requirement for Lck during primary and memory CD8+ T cell responses.

Tewari K, Walent J, Svaren J, Zamoyska R, Suresh M.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16388-93. Epub 2006 Oct 23.


Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.

Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R.

Mol Cell Biol. 2006 Nov;26(22):8655-65. Epub 2006 Sep 11.


Do CD8 effector cells need IL-7R expression to become resting memory cells?

Buentke E, Mathiot A, Tolaini M, Di Santo J, Zamoyska R, Seddon B.

Blood. 2006 Sep 15;108(6):1949-56. Epub 2006 May 16.


Switching sides: transcriptional control of CD4 thymocyte lineage commitment.

Zamoyska R.

Nat Immunol. 2005 Apr;6(4):363-4. No abstract available.


Signalling in T-lymphocyte development: integration of signalling pathways is the key.

Zamoyska R, Lovatt M.

Curr Opin Immunol. 2004 Apr;16(2):191-6. Review.


Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells.

Seddon B, Tomlinson P, Zamoyska R.

Nat Immunol. 2003 Jul;4(7):680-6. Epub 2003 Jun 15.


Regulation of peripheral T-cell homeostasis by receptor signalling.

Seddon B, Zamoyska R.

Curr Opin Immunol. 2003 Jun;15(3):321-4. Review.


Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells.

Kassiotis G, Zamoyska R, Stockinger B.

J Exp Med. 2003 Apr 21;197(8):1007-16.


The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation.

Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B.

Immunol Rev. 2003 Feb;191:107-18. Review.


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