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Items: 48

1.

NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY.

Czopek A, Zagorska A, Kolaczkowski M, Bucki A, Gryzlo B, Rychtyk J, Pawlowsk M, Siwek A, Satala G, Bojarski A, Kubacka M, Filipek B.

Acta Pol Pharm. 2016 Nov;73(6):1545-1554.

PMID:
29634109
2.

Phosphodiesterase 10 Inhibitors - Novel Perspectives for Psychiatric and Neurodegenerative Drug Discovery.

Zagorska A, Partyka A, Bucki A, Gawalska A, Czopek A, Pawlowski M.

Curr Med Chem. 2018 Mar 8. doi: 10.2174/0929867325666180309110629. [Epub ahead of print]

PMID:
29521210
3.

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.

Marcinkowska M, Kotańska M, Zagórska A, Śniecikowska J, Kubacka M, Siwek A, Bucki A, Pawłowski M, Bednarski M, Sapa J, Starek M, Dąbrowska M, Kołaczkowski M.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):536-545. doi: 10.1080/14756366.2018.1437155.

PMID:
29482394
4.

Web-based platform for patient dose surveys in diagnostic and interventional radiology in Bulgaria: Functionality testing and optimisation.

Simeonov F, Palov N, Ivanova D, Kostova-Lefterova D, Georgiev E, Zagorska A, Madzharova R, Vassileva J.

Phys Med. 2017 Sep;41:87-92. doi: 10.1016/j.ejmp.2017.04.025. Epub 2017 May 4.

PMID:
28479283
5.

Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.

Chłoń-Rzepa G, Zagórska A, Żmudzki P, Bucki A, Kołaczkowski M, Partyka A, Wesołowska A, Kazek G, Głuch-Lutwin M, Siwek A, Starowicz G, Pawłowski M.

Arch Pharm (Weinheim). 2016 Dec;349(12):889-903. doi: 10.1002/ardp.201600260. Epub 2016 Nov 21.

PMID:
27869315
6.

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.

Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M.

J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. Epub 2016 Jun 29.

PMID:
27353547
7.

Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.

Czopek A, Byrtus H, Zagórska A, Siwek A, Kazek G, Bednarski M, Sapa J, Pawłowski M.

Pharmacol Rep. 2016 Oct;68(5):886-93. doi: 10.1016/j.pharep.2016.04.018. Epub 2016 May 21.

PMID:
27351944
8.

RECEPTOR AFFINITY AND PHOSPHODIESTERASES 4B AND 10A ACTIVITY OF OCTAHYDRO- AND 6,7-DIMETHOXY-3,4-DIHYDRO- ISOQUINOLIN-2(1H)-YL-ALKYL DERIVATIVES OF IMIDAZO- AND PYRIMIDINO[2,1-f]PURINES.

Zagórska A, Gryzło B, Satała G, Bojarski AJ, Głuch-Lutwin M, Mordyl B, Kazek G, Pawłowski M.

Acta Pol Pharm. 2016 Mar-Apr;73(2):369-77.

PMID:
27180429
9.

TAM receptors regulate multiple features of microglial physiology.

Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, Lemke G.

Nature. 2016 Apr 14;532(7598):240-244. doi: 10.1038/nature17630. Epub 2016 Apr 6.

10.

REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY STUDY OF LIPOPHILICITY OF IMIDAZO[2,1-F]THEOPHYLLINE DERIVATIVES.

Zagórska A, Czopek A, Pełka K, Bajda M, Stanisz-Wallis K, Pawłowski M.

Acta Pol Pharm. 2015 Jul-Aug;72(4):663-9.

11.

The Relative Efficacy And Safety Of Treatments In Second-Line Management Of Chronic Myeloid Leukaemia: Systematic Review And Network Meta-Analysis Feasibility Study.

Kroes MA, Witkowski MA, Paine A, Zagorska A, Almeida AM.

Value Health. 2015 Nov;18(7):A435. doi: 10.1016/j.jval.2015.09.1047. Epub 2015 Oct 20. No abstract available.

12.

Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation.

Fuhs SR, Meisenhelder J, Aslanian A, Ma L, Zagorska A, Stankova M, Binnie A, Al-Obeidi F, Mauger J, Lemke G, Yates JR 3rd, Hunter T.

Cell. 2015 Jul 2;162(1):198-210. doi: 10.1016/j.cell.2015.05.046.

13.

Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.

Zagórska A, Kołaczkowski M, Bucki A, Siwek A, Kazek G, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pawłowski M.

Eur J Med Chem. 2015 Jun 5;97:142-54. doi: 10.1016/j.ejmech.2015.04.046. Epub 2015 May 1.

PMID:
25965777
14.

Eye lens exposure to medical staff during endoscopic retrograde cholangiopancreatography.

Zagorska A, Romanova K, Hristova-Popova J, Vassileva J, Katzarov K.

Phys Med. 2015 Nov;31(7):781-4. doi: 10.1016/j.ejmp.2015.03.011. Epub 2015 May 1.

PMID:
25937006
15.

Risk of radiation exposure to medical staff involved in interventional endourology.

Hristova-Popova J, Zagorska A, Saltirov I, Petkova K, Vassileva J.

Radiat Prot Dosimetry. 2015 Jul;165(1-4):268-71. doi: 10.1093/rpd/ncv089. Epub 2015 Apr 7.

PMID:
25855076
16.

New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.

Chłoń-Rzepa G, Zagórska A, Bucki A, Kołaczkowski M, Pawłowski M, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pękala E, Słoczyńska K.

Arch Pharm (Weinheim). 2015 Apr;348(4):242-53. doi: 10.1002/ardp.201500015. Epub 2015 Mar 13.

PMID:
25773907
17.

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.

Dransfield I, Zagórska A, Lew ED, Michail K, Lemke G.

Cell Death Dis. 2015 Feb 19;6:e1646. doi: 10.1038/cddis.2015.18.

18.

The Relative Efficacy of Treatments in First-Line Management of Newly Diagnosed Chronic Myeloid Leukaemia: Systematic Literature Review and Indirect Comparison.

Kroes M, Zagorska A, Osei-Assibey G, Paine A.

Value Health. 2014 Nov;17(7):A615. doi: 10.1016/j.jval.2014.08.2165. Epub 2014 Oct 26. No abstract available.

19.

Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives.

Zagórska A, Czopek A, Pełka K, Stanisz-Wallis K, Pawłowski M.

Acta Pol Pharm. 2014 May-Jun;71(3):379-83.

20.

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G.

Elife. 2014 Sep 29;3. doi: 10.7554/eLife.03385.

21.

Diversification of TAM receptor tyrosine kinase function.

Zagórska A, Través PG, Lew ED, Dransfield I, Lemke G.

Nat Immunol. 2014 Oct;15(10):920-8. doi: 10.1038/ni.2986. Epub 2014 Sep 7.

22.

Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders.

Partyka A, Jarosz J, Wasik A, Jastrzębska-Więsek M, Zagórska A, Pawłowski M, Wesołowska A.

J Pharm Pharmacol. 2014 Dec;66(12):1755-62. doi: 10.1111/jphp.12305. Epub 2014 Aug 13.

PMID:
25131522
23.

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity.

Zygmunt M, Sapa J, Chłoń-Rzepa G, Zagórska A, Siwek A, Pawłowski M, Nowak G.

Pharmacol Rep. 2014 Jun;66(3):505-10. doi: 10.1016/j.pharep.2013.12.014. Epub 2014 Apr 13.

PMID:
24905531
24.

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

Banerjee S, Zagórska A, Deak M, Campbell DG, Prescott AR, Alessi DR.

Biochem J. 2014 Jul 15;461(2):233-45. doi: 10.1042/BJ20140408.

25.

Synthesis and pharmacological evaluation of novel tricyclic[2,1-f]theophylline derivatives.

Zagórska A, Pawłowski M, Siwek A, Kazek G, Partyka A, Wróbel D, Jastrzębska-Więsek M, Wesołowska A.

Arch Pharm (Weinheim). 2013 Nov;346(11):832-9. doi: 10.1002/ardp.201300257. Epub 2013 Oct 1.

PMID:
24123186
26.

A program to support self-efficacy among athletes.

Zagórska A, Guszkowska M.

Scand J Med Sci Sports. 2014 Jun;24(3):e121-8. doi: 10.1111/sms.12125. Epub 2013 Oct 10.

PMID:
24118561
27.

Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.

Bhattacharyya S, Zagórska A, Lew ED, Shrestha B, Rothlin CV, Naughton J, Diamond MS, Lemke G, Young JA.

Cell Host Microbe. 2013 Aug 14;14(2):136-47. doi: 10.1016/j.chom.2013.07.005.

28.

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H.

J Exp Med. 2012 Oct 22;209(11):2033-47. doi: 10.1084/jem.20120493. Epub 2012 Oct 15.

29.

Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.

Zagórska A, Czopek A, Pawłowski M, Dybała M, Siwek A, Nowak G.

Med Chem Res. 2012 Nov;21(11):3455-3459. Epub 2011 Nov 19.

30.

Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice.

Jazwa A, Kucharzewska P, Leja J, Zagorska A, Sierpniowska A, Stepniewski J, Kozakowska M, Taha H, Ochiya T, Derlacz R, Vahakangas E, Yla-Herttuala S, Jozkowicz A, Dulak J.

Genet Vaccines Ther. 2010 Aug 30;8:6. doi: 10.1186/1479-0556-8-6.

31.

Synthesis and anticonvulsant properties of new Mannich bases derived from 3-aryl-pyrrolidine-2,5-diones. Part 1.

Obniska J, Kopytko M, Zagórska A, Chlebek I, Kamiński K.

Arch Pharm (Weinheim). 2010 Jun;343(6):333-41. doi: 10.1002/ardp.200900250.

PMID:
20379970
32.

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR.

Sci Signal. 2010 Mar 30;3(115):ra25. doi: 10.1126/scisignal.2000616.

33.

Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.

Zagórska A, Jurczyk S, Pawłowski M, Dybała M, Nowak G, Tatarczyńska E, Nikiforuk A, Chojnacka-Wójcik E.

Eur J Med Chem. 2009 Nov;44(11):4288-96. doi: 10.1016/j.ejmech.2009.07.014. Epub 2009 Jul 21.

PMID:
19679379
34.

Heme oxygenase-1 accelerates cutaneous wound healing in mice.

Grochot-Przeczek A, Lach R, Mis J, Skrzypek K, Gozdecka M, Sroczynska P, Dubiel M, Rutkowski A, Kozakowska M, Zagorska A, Walczynski J, Was H, Kotlinowski J, Drukala J, Kurowski K, Kieda C, Herault Y, Dulak J, Jozkowicz A.

PLoS One. 2009 Jun 4;4(6):e5803. doi: 10.1371/journal.pone.0005803.

35.

Interfering with Wnt signalling alters the periodicity of the segmentation clock.

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK.

Dev Biol. 2009 Jun 1;330(1):21-31. doi: 10.1016/j.ydbio.2009.02.035. Epub 2009 Mar 6.

36.

Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.

Hur W, Velentza A, Kim S, Flatauer L, Jiang X, Valente D, Mason DE, Suzuki M, Larson B, Zhang J, Zagorska A, Didonato M, Nagle A, Warmuth M, Balk SP, Peters EC, Gray NS.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5916-9. doi: 10.1016/j.bmcl.2008.07.062. Epub 2008 Jul 18.

37.

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.

Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR.

Biochem J. 2008 Apr 15;411(2):249-60. doi: 10.1042/BJ20080067.

PMID:
18254724
38.

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.

Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR.

J Cell Biol. 2007 Jan 1;176(1):89-100. Epub 2006 Dec 26.

39.

SUMO protease SENP1 induces isomerization of the scissile peptide bond.

Shen L, Tatham MH, Dong C, Zagórska A, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2006 Dec;13(12):1069-77. Epub 2006 Nov 12.

40.

Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes.

Jazwa A, Loboda A, Golda S, Cisowski J, Szelag M, Zagorska A, Sroczynska P, Drukala J, Jozkowicz A, Dulak J.

Free Radic Biol Med. 2006 Apr 1;40(7):1250-63. Epub 2005 Dec 19.

41.
42.

New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes.

Dulak J, Zagorska A, Wegiel B, Loboda A, Jozkowicz A.

Cell Biochem Biophys. 2006;44(1):31-42. Review.

43.

Atorvastatin affects several angiogenic mediators in human endothelial cells.

Dulak J, Loboda A, Jazwa A, Zagorska A, Dörler J, Alber H, Dichtl W, Weidinger F, Frick M, Jozkowicz A.

Endothelium. 2005 Sep-Dec;12(5-6):233-41.

44.

Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part I.

Obniska J, Dzierzawska-Majewska A, Zagorska A, Zajdel P, Karolak-Wojciechowska J.

Farmaco. 2005 Jun-Jul;60(6-7):529-39.

PMID:
15950973
45.

HIF-1: the knowns and unknowns of hypoxia sensing.

Zagórska A, Dulak J.

Acta Biochim Pol. 2004;51(3):563-85. Review.

46.

Complex role of heme oxygenase-1 in angiogenesis.

Dulak J, Łoboda A, Zagórska A, Józkowicz A.

Antioxid Redox Signal. 2004 Oct;6(5):858-66. Review.

PMID:
15345146
48.

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