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Items: 1 to 50 of 104

1.

Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction.

Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR.

Mol Pharmacol. 2018 May 11. pii: mol.118.112144. doi: 10.1124/mol.118.112144. [Epub ahead of print]

2.

2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice.

Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR.

Toxicol Appl Pharmacol. 2018 Jun 1;348:85-98. doi: 10.1016/j.taap.2018.04.013. Epub 2018 Apr 16.

PMID:
29673856
3.

Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17].

Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR.

Toxicol Appl Pharmacol. 2018 Apr 1;344:74. doi: 10.1016/j.taap.2018.03.001. Epub 2018 Mar 2. No abstract available.

PMID:
29501526
4.

Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds.

Fader KA, Zacharewski TR.

Curr Opin Toxicol. 2017 Feb;2:36-41. doi: 10.1016/j.cotox.2017.01.010. Epub 2017 Feb 1.

5.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR.

Sci Rep. 2017 Jul 19;7(1):5921. doi: 10.1038/s41598-017-05656-8.

6.

TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.

Stedtfeld RD, Stedtfeld TM, Fader KA, Williams MR, Bhaduri P, Quensen J, Zacharewski TR, Tiedje JM, Hashsham SA.

FEMS Microbiol Ecol. 2017 May 1;93(5). doi: 10.1093/femsec/fix058.

7.

Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Nault R, Fader KA, Lydic TA, Zacharewski TR.

Chem Res Toxicol. 2017 Apr 17;30(4):1060-1075. doi: 10.1021/acs.chemrestox.6b00430. Epub 2017 Mar 20.

8.

Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR.

Toxicol Appl Pharmacol. 2017 Apr 15;321:1-17. doi: 10.1016/j.taap.2017.02.006. Epub 2017 Feb 16. Erratum in: Toxicol Appl Pharmacol. 2018 Mar 1;:.

9.

Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells.

Kovalova N, Nault R, Crawford R, Zacharewski TR, Kaminski NE.

Toxicol Appl Pharmacol. 2017 Feb 1;316:95-106. doi: 10.1016/j.taap.2016.11.009. Epub 2016 Nov 30.

10.

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP.

Toxicol Sci. 2016 Dec;154(2):381-391. Epub 2016 Sep 9.

11.

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP.

Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703. Epub 2016 Feb 26.

12.

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR.

Toxicol Sci. 2016 Feb;149(2):358-71. doi: 10.1093/toxsci/kfv245. Epub 2015 Nov 17.

13.

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ.

PLoS One. 2015 Sep 30;10(9):e0139270. doi: 10.1371/journal.pone.0139270. eCollection 2015.

14.

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR.

Toxicol Sci. 2015 Dec;148(2):567-80. doi: 10.1093/toxsci/kfv206. Epub 2015 Sep 16.

15.

Atrazine-Mediated Disruption of Steroidogenesis in BLTK1 Murine Leydig Cells.

Karmaus AL, Zacharewski TR.

Toxicol Sci. 2015 Dec;148(2):544-54. doi: 10.1093/toxsci/kfv204. Epub 2015 Sep 16.

PMID:
26377646
16.

Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.

Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):331-40. doi: 10.1165/rcmb.2015-0165OC.

PMID:
26203683
17.

Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features.

Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR.

Toxicol Pathol. 2015 Apr;43(3):366-75. doi: 10.1177/0192623314544379. Epub 2014 Oct 1.

18.

o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats.

Kwekel JC, Forgacs AL, Williams KJ, Zacharewski TR.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):532-41. doi: 10.1016/j.taap.2013.09.024. Epub 2013 Oct 3.

PMID:
24096037
19.

Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver.

Nault R, Forgacs AL, Dere E, Zacharewski TR.

Toxicol Lett. 2013 Oct 23;223(1):52-9. doi: 10.1016/j.toxlet.2013.08.013. Epub 2013 Aug 29.

20.

Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice.

Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR.

Toxicol Sci. 2013 Oct;135(2):465-75. doi: 10.1093/toxsci/kft156. Epub 2013 Jul 17.

21.

PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.

Kim S, Kiyosawa N, Burgoon LD, Chang CC, Zacharewski TR.

J Steroid Biochem Mol Biol. 2013 Nov;138:236-47. doi: 10.1016/j.jsbmb.2013.06.004. Epub 2013 Jun 27.

PMID:
23811191
22.

Triazine herbicides and their chlorometabolites alter steroidogenesis in BLTK1 murine Leydig cells.

Forgacs AL, D'Souza ML, Huhtaniemi IT, Rahman NA, Zacharewski TR.

Toxicol Sci. 2013 Jul;134(1):155-67. doi: 10.1093/toxsci/kft096. Epub 2013 Apr 16.

PMID:
23591565
23.

Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes.

Forgacs AL, Dere E, Angrish MM, Zacharewski TR.

Toxicol Sci. 2013 May;133(1):54-66. doi: 10.1093/toxsci/kft028. Epub 2013 Feb 15.

24.

Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice.

Nault R, Kim S, Zacharewski TR.

Toxicol Appl Pharmacol. 2013 Mar 1;267(2):184-91. doi: 10.1016/j.taap.2012.11.028. Epub 2012 Dec 11.

25.

TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice.

Angrish MM, Dominici CY, Zacharewski TR.

Toxicol Sci. 2013 Jan;131(1):108-15. doi: 10.1093/toxsci/kfs277. Epub 2012 Sep 13.

26.

Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.

Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR.

Toxicol Appl Pharmacol. 2012 Jul 15;262(2):124-38. doi: 10.1016/j.taap.2012.04.026. Epub 2012 Apr 28.

27.

Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice.

Angrish MM, Mets BD, Jones AD, Zacharewski TR.

Toxicol Sci. 2012 Aug;128(2):377-86. doi: 10.1093/toxsci/kfs155. Epub 2012 Apr 26.

28.

BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants.

Forgacs AL, Ding Q, Jaremba RG, Huhtaniemi IT, Rahman NA, Zacharewski TR.

Toxicol Sci. 2012 Jun;127(2):391-402. doi: 10.1093/toxsci/kfs121. Epub 2012 Mar 29.

PMID:
22461451
29.

Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.

Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM.

Toxicol Appl Pharmacol. 2012 Feb 15;259(1):13-26. doi: 10.1016/j.taap.2011.11.012. Epub 2011 Dec 1.

30.

Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver.

Forgacs AL, Kent MN, Makley MK, Mets B, DelRaso N, Jahns GL, Burgoon LD, Zacharewski TR, Reo NV.

Toxicol Sci. 2012 Jan;125(1):41-55. doi: 10.1093/toxsci/kfr262. Epub 2011 Sep 29.

31.

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.

Angrish MM, Jones AD, Harkema JR, Zacharewski TR.

Toxicol Sci. 2011 Dec;124(2):299-310. doi: 10.1093/toxsci/kfr226. Epub 2011 Sep 2.

32.

Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.

Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR.

Toxicol Appl Pharmacol. 2011 Oct 15;256(2):154-67. doi: 10.1016/j.taap.2011.08.002. Epub 2011 Aug 7.

33.

Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver.

Dere E, Lo R, Celius T, Matthews J, Zacharewski TR.

BMC Genomics. 2011 Jul 15;12:365. doi: 10.1186/1471-2164-12-365.

34.

Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA.

Toxicol Sci. 2011 Sep;123(1):58-70. doi: 10.1093/toxsci/kfr164. Epub 2011 Jun 28.

35.

Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells.

Dere E, Lee AW, Burgoon LD, Zacharewski TR.

BMC Genomics. 2011 Apr 15;12:193. doi: 10.1186/1471-2164-12-193.

36.

Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes.

Dere E, Forgacs AL, Zacharewski TR, Burgoon LD.

Chem Res Toxicol. 2011 Apr 18;24(4):494-504. doi: 10.1021/tx100328r. Epub 2011 Mar 17.

37.

Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Potter D, Sharratt B, Harkema JR, Rowlands JC, Budinsky RA, Zacharewski TR.

Toxicol Sci. 2010 Nov;118(1):286-97. doi: 10.1093/toxsci/kfq236. Epub 2010 Aug 11.

38.

Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice.

Fong CJ, Burgoon LD, Williams KJ, Jones AD, Forgacs AL, Zacharewski TR.

J Mol Endocrinol. 2010 Sep;45(3):161-73. doi: 10.1677/JME-09-0158. Epub 2010 Jul 13.

PMID:
20628019
39.

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.

Kopec AK, Burgoon LD, Ibrahim-Aibo D, Mets BD, Tashiro C, Potter D, Sharratt B, Harkema JR, Zacharewski TR.

Toxicol Appl Pharmacol. 2010 Mar 15;243(3):359-71. doi: 10.1016/j.taap.2009.12.003. Epub 2009 Dec 18.

40.

Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells.

Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR.

Toxicol Sci. 2009 Nov;112(1):229-44. doi: 10.1093/toxsci/kfp189. Epub 2009 Aug 14.

41.

Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice.

Burgoon LD, Ding Q, N'jai A, Dere E, Burg AR, Rowlands JC, Budinsky RA, Stebbins KE, Zacharewski TR.

Toxicol Sci. 2009 Nov;112(1):221-8. doi: 10.1093/toxsci/kfp180. Epub 2009 Aug 12.

PMID:
19675144
42.

Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program.

Kwekel JC, Forgacs AL, Burgoon LD, Williams KJ, Zacharewski TR.

BMC Med Genomics. 2009 Apr 28;2:19. doi: 10.1186/1755-8794-2-19.

43.

Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.

Kiyosawa N, Kwekel JC, Burgoon LD, Dere E, Williams KJ, Tashiro C, Chittim B, Zacharewski TR.

BMC Genomics. 2008 Oct 16;9:487. doi: 10.1186/1471-2164-9-487.

44.

Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response.

Frericks M, Burgoon LD, Zacharewski TR, Esser C.

Toxicol Appl Pharmacol. 2008 Oct 15;232(2):268-79. doi: 10.1016/j.taap.2008.07.009. Epub 2008 Jul 19.

PMID:
18691609
45.

Bioinformatics: databasing and gene annotation.

Burgoon LD, Zacharewski TR.

Methods Mol Biol. 2008;460:145-57. doi: 10.1007/978-1-60327-048-9_7.

PMID:
18449486
46.

Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets.

Burgoon LD, Zacharewski TR.

Toxicol Sci. 2008 Aug;104(2):412-8. doi: 10.1093/toxsci/kfn083. Epub 2008 Apr 25.

PMID:
18441342
47.

Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice.

N'Jai A, Boverhof DR, Dere E, Burgoon LD, Tan YS, Rowlands JC, Budinsky RA, Stebbins KE, Zacharewski TR.

Toxicol Sci. 2008 Jun;103(2):285-97. doi: 10.1093/toxsci/kfn053. Epub 2008 Mar 14.

PMID:
18343893
48.

Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice.

Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR.

Toxicol Sci. 2008 Mar;102(1):61-75. Epub 2007 Nov 27.

PMID:
18042819
49.

o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.

Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C, Chittim B, Zacharewski TR.

Toxicol Sci. 2008 Feb;101(2):350-63. Epub 2007 Nov 5. Erratum in: Toxicol Sci. 2008 Sep;105(1):231.

PMID:
17984292
50.

Inhibition of estrogen-mediated uterine gene expression responses by dioxin.

Boverhof DR, Burgoon LD, Williams KJ, Zacharewski TR.

Mol Pharmacol. 2008 Jan;73(1):82-93. Epub 2007 Oct 17.

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