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Items: 1 to 50 of 367

1.

A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation.

Palazzo E, Kellett MD, Cataisson C, Bible PW, Bhattacharya S, Sun HW, Gormley AC, Yuspa SH, Morasso MI.

Cell Death Differ. 2017 Apr;24(4):717-730. doi: 10.1038/cdd.2017.5. Epub 2017 Feb 10.

2.

Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant.

Shukla A, Yang Y, Madanikia S, Ho Y, Li M, Sanchez V, Cataisson C, Huang J, Yuspa SH.

PLoS One. 2016 Aug 18;11(8):e0161410. doi: 10.1371/journal.pone.0161410. eCollection 2016. Erratum in: PLoS One. 2016 Dec 12;11(12 ):e0168629.

3.

Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas.

Mascia F, Schloemann DT, Cataisson C, McKinnon KM, Krymskaya L, Wolcott KM, Yuspa SH.

Int J Cancer. 2016 Dec 1;139(11):2593-7. doi: 10.1002/ijc.30376. Epub 2016 Aug 29.

4.

MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.

Cataisson C, Michalowski AM, Shibuya K, Ryscavage A, Klosterman M, Wright L, Dubois W, Liu F, Zhuang A, Rodrigues KB, Hoover S, Dwyer J, Simpson MR, Merlino G, Yuspa SH.

Sci Signal. 2016 Jun 21;9(433):ra62. doi: 10.1126/scisignal.aaf5106.

PMID:
27330189
5.

Science Signaling Podcast for 21 June 2016: MET and skin cancer.

Yuspa SH, VanHook AM.

Sci Signal. 2016 Jun 21;9(433):pc14. doi: 10.1126/scisignal.aag2899.

PMID:
27330186
6.

Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.

Kelsey JS, Cataisson C, Chen J, Herrmann MA, Petersen ME, Baumann DO, McGowan KM, Yuspa SH, Keck GE, Blumberg PM.

Mol Carcinog. 2016 Dec;55(12):2183-2195. doi: 10.1002/mc.22460. Epub 2016 Feb 9.

PMID:
26859836
7.

The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth.

Palazzo E, Kellett M, Cataisson C, Gormley A, Bible PW, Pietroni V, Radoja N, Hwang J, Blumenberg M, Yuspa SH, Morasso MI.

Oncogene. 2016 Jun 16;35(24):3114-24. doi: 10.1038/onc.2015.380. Epub 2015 Nov 2.

8.

Keratinocyte p38δ loss inhibits Ras-induced tumor formation, while systemic p38δ loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin.

Kiss A, Koppel AC, Anders J, Cataisson C, Yuspa SH, Blumenberg M, Efimova T.

Mol Carcinog. 2016 May;55(5):563-74. doi: 10.1002/mc.22303. Epub 2015 Mar 8.

PMID:
25753147
9.

Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.

Peretti M, Angelini M, Savalli N, Florio T, Yuspa SH, Mazzanti M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2523-31. doi: 10.1016/j.bbamem.2014.12.012. Epub 2014 Dec 26. Review.

10.

Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.

Balmain A, Yuspa SH.

J Invest Dermatol. 2014 Oct 10;134(e1):E2-7. doi: 10.1038/skinbio.2014.2. Review. No abstract available.

11.

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

Padmakumar V, Masiuk KE, Luger D, Lee C, Coppola V, Tessarollo L, Hoover SB, Karavanova I, Buonanno A, Simpson RM, Yuspa SH.

BMC Dev Biol. 2014 May 28;14:24. doi: 10.1186/1471-213X-14-24.

12.

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JS, Wharton J, Zhao L, Wilkins MR.

Circulation. 2014 Apr 29;129(17):1770-80. doi: 10.1161/CIRCULATIONAHA.113.006797. Epub 2014 Feb 6.

13.

Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.

Mascia F, Lam G, Keith C, Garber C, Steinberg SM, Kohn E, Yuspa SH.

Sci Transl Med. 2013 Aug 21;5(199):199ra110. doi: 10.1126/scitranslmed.3005773.

14.

Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis.

Hattinger E, Zwicker S, Ruzicka T, Yuspa SH, Wolf R.

Curr Opin Pharmacol. 2013 Aug;13(4):588-94. doi: 10.1016/j.coph.2013.04.007. Epub 2013 May 9. Review.

PMID:
23664757
15.

MyD88 and its divergent toll in carcinogenesis.

Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G.

Trends Immunol. 2013 Aug;34(8):379-89. doi: 10.1016/j.it.2013.03.008. Epub 2013 May 7. Review.

16.

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.

Ansbro MR, Shukla S, Ambudkar SV, Yuspa SH, Li L.

PLoS One. 2013 Apr 10;8(4):e60334. doi: 10.1371/journal.pone.0060334. Print 2013.

17.

CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma.

Shukla A, Edwards R, Yang Y, Hahn A, Folkers K, Ding J, Padmakumar VC, Cataisson C, Suh KS, Yuspa SH.

Oncogene. 2014 Feb 13;33(7):842-50. doi: 10.1038/onc.2013.18. Epub 2013 Feb 18.

18.

Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.

Sengupta A, Lichti UF, Carlson BA, Cataisson C, Ryscavage AO, Mikulec C, Conrad M, Fischer SM, Hatfield DL, Yuspa SH.

J Invest Dermatol. 2013 Jul;133(7):1731-41. doi: 10.1038/jid.2013.52. Epub 2013 Jan 30.

19.

Cutaneous retinoic acid levels determine hair follicle development and downgrowth.

Okano J, Levy C, Lichti U, Sun HW, Yuspa SH, Sakai Y, Morasso MI.

J Biol Chem. 2012 Nov 16;287(47):39304-15. doi: 10.1074/jbc.M112.397273. Epub 2012 Sep 24.

20.

Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.

Lao HC, Akunda JK, Chun KS, Flake GP, Yuspa SH, Langenbach R.

Carcinogenesis. 2012 Nov;33(11):2293-300. doi: 10.1093/carcin/bgs267. Epub 2012 Aug 17.

21.

Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.

Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH.

Am J Pathol. 2012 Jul;181(1):74-84. doi: 10.1016/j.ajpath.2012.03.025. Epub 2012 May 18.

22.

Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.

Yuspa SH, Kraemer KH, Dlugosz AA, Roop DR, Kulesz-Martin M, Bickenbach JR.

J Invest Dermatol. 2012 May;132(5):1317-20. doi: 10.1038/jid.2011.480. No abstract available.

23.

Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.

Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6130-5. doi: 10.1073/pnas.1201351109. Epub 2012 Apr 2.

24.

CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.

Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH.

Carcinogenesis. 2012 May;33(5):986-95. doi: 10.1093/carcin/bgs115. Epub 2012 Mar 1.

25.

Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development.

Okano J, Lichti U, Mamiya S, Aronova M, Zhang G, Yuspa SH, Hamada H, Sakai Y, Morasso MI.

J Cell Sci. 2012 Apr 1;125(Pt 7):1827-36. doi: 10.1242/jcs.101550. Epub 2012 Feb 24.

26.

The black box illuminated: signals and signaling.

Mascia F, Denning M, Kopan R, Yuspa SH.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):811-9. doi: 10.1038/jid.2011.406. Epub 2011 Dec 15. Review.

27.

S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.

Nasser MW, Qamri Z, Deol YS, Ravi J, Powell CA, Trikha P, Schwendener RA, Bai XF, Shilo K, Zou X, Leone G, Wolf R, Yuspa SH, Ganju RK.

Cancer Res. 2012 Feb 1;72(3):604-15. doi: 10.1158/0008-5472.CAN-11-0669. Epub 2011 Dec 12.

28.

Modeling the transcriptional consequences of epidermal growth factor receptor ablation in Ras-initiated squamous cancer.

Wright LN, Ryscavage A, Merlino G, Yuspa SH.

Clin Cancer Res. 2012 Jan 1;18(1):170-83. doi: 10.1158/1078-0432.CCR-11-1349. Epub 2011 Nov 8.

29.

Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma.

Patel GK, Yee CL, Terunuma A, Telford WG, Voong N, Yuspa SH, Vogel JC.

J Invest Dermatol. 2012 Feb;132(2):401-9. doi: 10.1038/jid.2011.317. Epub 2011 Oct 20.

30.

A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice.

Patel GK, Yee CL, Yuspa SH, Vogel JC.

J Invest Dermatol. 2012 Feb;132(2):284-90. doi: 10.1038/jid.2011.284. Epub 2011 Oct 6.

31.

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.

Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.

Oncogene. 2011 Nov 10;30(45):4590-4600. doi: 10.1038/onc.2011.166. Epub 2011 May 23.

32.

Gene from a psoriasis susceptibility locus primes the skin for inflammation.

Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH.

Sci Transl Med. 2010 Dec 8;2(61):61ra90. doi: 10.1126/scitranslmed.3001108.

33.

RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.

Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A, Bíró T, Yuspa SH, Blumberg PM.

Cancer Res. 2010 Oct 15;70(20):7905-17. doi: 10.1158/0008-5472.CAN-09-4729. Epub 2010 Sep 28.

34.

Selenoproteins are essential for proper keratinocyte function and skin development.

Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL.

PLoS One. 2010 Aug 18;5(8):e12249. doi: 10.1371/journal.pone.0012249.

36.

Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.

Wolf R, Ruzicka T, Yuspa SH.

Amino Acids. 2011 Oct;41(4):789-96. doi: 10.1007/s00726-010-0666-4. Epub 2010 Jul 2. Review.

PMID:
20596736
37.

S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.

Malik M, Shukla A, Amin P, Niedelman W, Lee J, Jividen K, Phang JM, Ding J, Suh KS, Curmi PM, Yuspa SH.

J Biol Chem. 2010 Jul 30;285(31):23818-28. doi: 10.1074/jbc.M109.091611. Epub 2010 May 26.

38.

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.

Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH.

Cancer Res. 2010 Jun 1;70(11):4509-19. doi: 10.1158/0008-5472.CAN-09-4303. Epub 2010 May 11.

39.

Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.

Pérez-Lorenzo R, Markell LM, Hogan KA, Yuspa SH, Glick AB.

Carcinogenesis. 2010 Jun;31(6):1116-23. doi: 10.1093/carcin/bgq041. Epub 2010 Feb 19.

40.

Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis.

Stepp MA, Pal-Ghosh S, Tadvalkar G, Rajjoub L, Jurjus RA, Gerdes M, Ryscavage A, Cataisson C, Shukla A, Yuspa SH.

Mol Carcinog. 2010 Apr;49(4):363-73. doi: 10.1002/mc.20609.

41.

EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo.

Mascia F, Cataisson C, Lee TC, Threadgill D, Mariani V, Amerio P, Chandrasekhara C, Souto Adeva G, Girolomoni G, Yuspa SH, Pastore S.

J Invest Dermatol. 2010 Mar;130(3):682-93. doi: 10.1038/jid.2009.336. Epub 2009 Nov 5.

42.

TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.

Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, Suh KS, Yuspa SH.

Nat Cell Biol. 2009 Jun;11(6):777-84. doi: 10.1038/ncb1885. Epub 2009 May 17.

43.

Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.

Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1725-30. doi: 10.1073/pnas.0812135106. Epub 2009 Jan 30.

44.

Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.

Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, Vonderhaar BK, Olson M, Watson PH, Yuspa SH.

Cancer Lett. 2009 May 8;277(1):101-7. doi: 10.1016/j.canlet.2008.11.032. Epub 2009 Jan 10.

45.

Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.

Cataisson C, Ohman R, Patel G, Pearson A, Tsien M, Jay S, Wright L, Hennings H, Yuspa SH.

Cancer Res. 2009 Jan 1;69(1):319-28. doi: 10.1158/0008-5472.CAN-08-2490.

46.

The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis.

Virador VM, Flores-Obando RE, Berry A, Patel R, Zakhari J, Lo YC, Strain K, Anders J, Cataisson C, Hansen LA, Yuspa SH.

Mol Carcinog. 2009 Jul;48(7):599-609. doi: 10.1002/mc.20498.

47.

Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.

Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.

J Immunol. 2008 Jul 15;181(2):1499-506.

49.

HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling.

Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM.

Blood. 2008 Apr 1;111(7):3343-54. doi: 10.1182/blood-2007-10-115758. Epub 2008 Jan 16.

50.

Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1.

Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH.

J Cell Sci. 2007 Aug 15;120(Pt 16):2851-63. Epub 2007 Jul 31.

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