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Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats.

Umbright C, Sellamuthu R, Roberts JR, Young SH, Richardson D, Schwegler-Berry D, McKinney W, Chen B, Gu JK, Kashon M, Joseph P.

J Toxicol Environ Health A. 2017;80(23-24):1349-1368. doi: 10.1080/15287394.2017.1384773.


Clozapine-induced maculopathy.

Tong JY, Pai A, Young SH.

Med J Aust. 2017 Sep 2;207(7):316. No abstract available.



Vaze A, Nguyen V, Daien V, Arnold JJ, Young SH, Cheung CM, Lamoureux E, Bhargava M, Barthelmes D, Gillies MC; Fight Retinal Blindness Study Group.

Retina. 2017 Aug 16. doi: 10.1097/IAE.0000000000001815. [Epub ahead of print]


Surgical Decompression for Chiari Malformation Type I: An Age-Based Outcomes Study Based on the Chicago Chiari Outcome Scale.

Gilmer HS, Xi M, Young SH.

World Neurosurg. 2017 Nov;107:285-290. doi: 10.1016/j.wneu.2017.07.162. Epub 2017 Aug 5.


Risk Factors for Upper Gastrointestinal Bleeding in Patients Taking Selective COX-2 Inhibitors: A Nationwide Population-Based Cohort Study.

Lin XH, Young SH, Luo JC, Peng YL, Chen PH, Lin CC, Chen WM, Hou MC, Lee FY.

Pain Med. 2018 Feb 1;19(2):225-231. doi: 10.1093/pm/pnx097.


Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.

Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13.


Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells.

Hao F, Xu Q, Zhao Y, Stevens JV, Young SH, Sinnett-Smith J, Rozengurt E.

Mol Cancer Res. 2017 Jul;15(7):929-941. doi: 10.1158/1541-7786.MCR-17-0023. Epub 2017 Mar 30.


Clozapine-induced maculopathy.

Tong JY, Pai A, Heydon P, Young SH.

Med J Aust. 2017 Apr 3;206(6):246. No abstract available.


Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats.

Sellamuthu R, Umbright C, Roberts JR, Young SH, Richardson D, McKinney W, Chen BT, Li S, Kashon M, Joseph P.

Inhal Toxicol. 2017 Feb;29(2):53-64. doi: 10.1080/08958378.2017.1282064. Epub 2017 Mar 19.


Prognostic Factors and Pattern of Long-Term Recovery with MLC601 (NeuroAiD™) in the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study.

Venketasubramanian N, Lee CF, Young SH, Tay SS, Umapathi T, Lao AY, Gan HH, Baroque Ii AC, Navarro JC, Chang HM, Advincula JM, Muengtaweepongsa S, Chan BP, Chua CL, Wijekoon N, de Silva HA, Hiyadan JH, Suwanwela NC, Wong KS, Poungvarin N, Eow GB, Chen CL; CHIMES-E Study Investigators.

Cerebrovasc Dis. 2017;43(1-2):36-42. doi: 10.1159/000452285. Epub 2016 Nov 15.


Cholecystectomy Reduces Recurrent Pancreatitis and Improves Survival After Endoscopic Sphincterotomy.

Young SH, Peng YL, Lin XH, Chen YT, Luo JC, Wang YP, Hou MC, Lee FY.

J Gastrointest Surg. 2017 Feb;21(2):294-301. doi: 10.1007/s11605-016-3284-y. Epub 2016 Oct 27.


Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).

Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E.

J Biol Chem. 2016 Aug 19;291(34):17988-8005. doi: 10.1074/jbc.M115.711275. Epub 2016 Jul 1.


Analysis of baseline hepatitis B virus DNA levels in chronic hepatitis B patients with non-hematological malignancies prior to the initiation of cancer chemotherapy.

Young SH, Wei TH, Lin CC, Chu CJ, Lee FY, Yu MI, Lu RH, Chang CY, Yang PL, Wang MH, Lin HC.

Mol Clin Oncol. 2016 Jul;5(1):165-170. Epub 2016 Apr 14.


Comparison of cell counting methods in rodent pulmonary toxicity studies: automated and manual protocols and considerations for experimental design.

Zeidler-Erdely PC, Antonini JM, Meighan TG, Young SH, Eye TJ, Hammer MA, Erdely A.

Inhal Toxicol. 2016 Aug;28(9):410-20. doi: 10.1080/08958378.2016.1189985. Epub 2016 Jun 2.


Will saliva test be a good method to detect Helicobacter pylori in H. pylori-infected patients?

Young SH, Luo JC.

J Chin Med Assoc. 2016 Jul;79(7):351-2. doi: 10.1016/j.jcma.2016.03.005. Epub 2016 Apr 16. No abstract available.


Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.

Wang J, Han L, Sinnett-Smith J, Han LL, Stevens JV, Rozengurt N, Young SH, Rozengurt E.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C542-57. doi: 10.1152/ajpcell.00302.2015. Epub 2016 Jan 6.


Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1.

Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G.

Am J Physiol Cell Physiol. 2015 Nov 15;309(10):C639-49. doi: 10.1152/ajpcell.00417.2014. Epub 2015 Aug 26.


CHInese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy.

Venketasubramanian N, Young SH, Tay SS, Umapathi T, Lao AY, Gan HH, Baroque AC 2nd, Navarro JC, Chang HM, Advincula JM, Muengtaweepongsa S, Chan BP, Chua CL, Wijekoon N, de Silva HA, Hiyadan JH, Suwanwela NC, Wong KS, Poungvarin N, Eow GB, Lee CF, Chen CL; CHIMES-E Study Investigators.

Cerebrovasc Dis. 2015;39(5-6):309-18. doi: 10.1159/000382082. Epub 2015 Apr 22.


Countrywide stroke incidence, subtypes, management and outcome in a multiethnic Asian population: the Singapore Stroke Registry--methodology.

Venketasubramanian N, Chang HM, Chan BP, Young SH, Kong KH, Tang KF, Ang YH, Ahmad A, Chow KY; Singapore Stroke Registry.

Int J Stroke. 2015 Jul;10(5):767-9. doi: 10.1111/ijs.12472. Epub 2015 Mar 5.


Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.

Soares HP, Ming M, Mellon M, Young SH, Han L, Sinnet-Smith J, Rozengurt E.

Mol Cancer Ther. 2015 Apr;14(4):1014-23. doi: 10.1158/1535-7163.MCT-14-0669. Epub 2015 Feb 11.


Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.

Ming M, Sinnett-Smith J, Wang J, Soares HP, Young SH, Eibl G, Rozengurt E.

PLoS One. 2014 Dec 10;9(12):e114573. doi: 10.1371/journal.pone.0114573. eCollection 2014.


Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats.

Erdely A, Antonini JM, Young SH, Kashon ML, Gu JK, Hulderman T, Salmen R, Meighan T, Roberts JR, Zeidler-Erdely PC.

Part Fibre Toxicol. 2014 Aug 15;11:34. doi: 10.1186/s12989-014-0034-8.


Interactive effects of cerium oxide and diesel exhaust nanoparticles on inducing pulmonary fibrosis.

Ma JY, Young SH, Mercer RR, Barger M, Schwegler-Berry D, Ma JK, Castranova V.

Toxicol Appl Pharmacol. 2014 Jul 15;278(2):135-47. doi: 10.1016/j.taap.2014.04.019. Epub 2014 May 2.


Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.

Sinnett-Smith J, Ni Y, Wang J, Ming M, Young SH, Rozengurt E.

Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. doi: 10.1152/ajpcell.00048.2014. Epub 2014 Mar 19.


Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses.

Siegrist KJ, Reynolds SH, Kashon ML, Lowry DT, Dong C, Hubbs AF, Young SH, Salisbury JL, Porter DW, Benkovic SA, McCawley M, Keane MJ, Mastovich JT, Bunker KL, Cena LG, Sparrow MC, Sturgeon JL, Dinu CZ, Sargent LM.

Part Fibre Toxicol. 2014 Jan 30;11:6. doi: 10.1186/1743-8977-11-6.


Intracellular Ca2+ oscillations generated via the Ca2+-sensing receptor are mediated by negative feedback by PKCα at Thr888.

Young SH, Rey O, Sinnett-Smith J, Rozengurt E.

Am J Physiol Cell Physiol. 2014 Feb 1;306(3):C298-306. doi: 10.1152/ajpcell.00194.2013. Epub 2013 Dec 11.


PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.

Ni Y, Sinnett-Smith J, Young SH, Rozengurt E.

PLoS One. 2013 Sep 9;8(9):e73149. doi: 10.1371/journal.pone.0073149. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/70d3c7b0-9718-4bb1-abed-d0defc3b7fc4.


Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study.

Chen CL, Young SH, Gan HH, Singh R, Lao AY, Baroque AC 2nd, Chang HM, Hiyadan JH, Chua CL, Advincula JM, Muengtaweepongsa S, Chan BP, de Silva HA, Towanabut S, Suwanwela NC, Poungvarin N, Chankrachang S, Wong KS, Eow GB, Navarro JC, Venketasubramanian N, Lee CF, Bousser MG; CHIMES Study Investigators.

Stroke. 2013 Aug;44(8):2093-100. doi: 10.1161/STROKEAHA.113.002055. Epub 2013 Jun 18.


Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease.

Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8555-60. doi: 10.1073/pnas.1306182110. Epub 2013 May 7.


Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats.

Roberts JR, Antonini JM, Porter DW, Chapman RS, Scabilloni JF, Young SH, Schwegler-Berry D, Castranova V, Mercer RR.

Part Fibre Toxicol. 2013 Mar 4;10:5. doi: 10.1186/1743-8977-10-5.


Adjuvant effect of zymosan after pulmonary treatment in a mouse ovalbumin allergy model.

Young SH, Wolfarth MG, Roberts JR, Kashon ML, Antonini JM.

Exp Lung Res. 2013 Feb;39(1):48-57. doi: 10.3109/01902148.2012.749960. Epub 2013 Jan 2.


Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.

Valenzuela NM, Hong L, Shen XD, Gao F, Young SH, Rozengurt E, Kupiec-Weglinski JW, Fishbein MC, Reed EF.

Am J Transplant. 2013 Feb;13(2):299-311. doi: 10.1111/ajt.12016. Epub 2012 Dec 27.


Ultrastructural and clinical evidence of subretinal debris accumulation in type 2 macular telangiectasia.

Cherepanoff S, Killingsworth MC, Zhu M, Nolan T, Hunyor AP, Young SH, Hageman GS, Gillies MC.

Br J Ophthalmol. 2012 Nov;96(11):1404-9. doi: 10.1136/bjophthalmol-2011-301009. Epub 2012 Sep 13.


HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells.

Ziegler ME, Jin YP, Young SH, Rozengurt E, Reed EF.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C872-82. doi: 10.1152/ajpcell.00199.2012. Epub 2012 Aug 22.


Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats.

Sellamuthu R, Umbright C, Roberts JR, Chapman R, Young SH, Richardson D, Cumpston J, McKinney W, Chen BT, Frazer D, Li S, Kashon M, Joseph P.

Inhal Toxicol. 2012 Aug;24(9):570-9. doi: 10.3109/08958378.2012.697926.


Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro.

Murray AR, Kisin E, Inman A, Young SH, Muhammed M, Burks T, Uheida A, Tkach A, Waltz M, Castranova V, Fadeel B, Kagan VE, Riviere JE, Monteiro-Riviere N, Shvedova AA.

Cell Biochem Biophys. 2013 Nov;67(2):461-76. doi: 10.1007/s12013-012-9367-9.


Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells.

Young SH, Rozengurt N, Sinnett-Smith J, Rozengurt E.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. doi: 10.1152/ajpgi.00025.2012. Epub 2012 May 17.


Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos.

Murray AR, Kisin ER, Tkach AV, Yanamala N, Mercer R, Young SH, Fadeel B, Kagan VE, Shvedova AA.

Part Fibre Toxicol. 2012 Apr 10;9:10. doi: 10.1186/1743-8977-9-10.


Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols.

Antonini JM, Zeidler-Erdely PC, Young SH, Roberts JR, Erdely A.

J Immunotoxicol. 2012 Apr-Jun;9(2):184-92. doi: 10.3109/1547691X.2011.650733. Epub 2012 Feb 28.


Single-walled carbon nanotube-induced mitotic disruption.

Sargent LM, Hubbs AF, Young SH, Kashon ML, Dinu CZ, Salisbury JL, Benkovic SA, Lowry DT, Murray AR, Kisin ER, Siegrist KJ, Battelli L, Mastovich J, Sturgeon JL, Bunker KL, Shvedova AA, Reynolds SH.

Mutat Res. 2012 Jun 14;745(1-2):28-37. doi: 10.1016/j.mrgentox.2011.11.017. Epub 2011 Dec 8.


Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.

Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E.

J Biol Chem. 2012 Jan 6;287(2):1158-67. doi: 10.1074/jbc.M111.274589. Epub 2011 Nov 17.


Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformation.

He X, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q.

Chem Res Toxicol. 2011 Dec 19;24(12):2237-48. doi: 10.1021/tx200351d. Epub 2011 Nov 22.


Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia.

Kan H, Wu Z, Young SH, Chen TH, Cumpston JL, Chen F, Kashon ML, Castranova V.

Nanotoxicology. 2012 Nov;6(7):736-45. doi: 10.3109/17435390.2011.611915. Epub 2011 Aug 30.


Identification of systemic markers from a pulmonary carbon nanotube exposure.

Erdely A, Liston A, Salmen-Muniz R, Hulderman T, Young SH, Zeidler-Erdely PC, Castranova V, Simeonova PP.

J Occup Environ Med. 2011 Jun;53(6 Suppl):S80-6. doi: 10.1097/JOM.0b013e31821ad724.


Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

Tkach AV, Shurin GV, Shurin MR, Kisin ER, Murray AR, Young SH, Star A, Fadeel B, Kagan VE, Shvedova AA.

ACS Nano. 2011 Jul 26;5(7):5755-62. doi: 10.1021/nn2014479. Epub 2011 Jun 15.


Blood gene expression profiling detects silica exposure and toxicity.

Sellamuthu R, Umbright C, Roberts JR, Chapman R, Young SH, Richardson D, Leonard H, McKinney W, Chen B, Frazer D, Li S, Kashon M, Joseph P.

Toxicol Sci. 2011 Aug;122(2):253-64. doi: 10.1093/toxsci/kfr125. Epub 2011 May 19.


Immunization from a photographic perspective: the 1961 polio trial in Nova Scotia.

Ashton R, Young SH.

CMAJ. 2011 Apr 19;183(7):E356-60. doi: 10.1503/cmaj.110286. Epub 2011 Apr 4. No abstract available.


Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice.

Zeidler-Erdely PC, Battelli LA, Stone S, Chen BT, Frazer DG, Young SH, Erdely A, Kashon ML, Andrews R, Antonini JM.

Inhal Toxicol. 2011 Feb;23(2):112-20. doi: 10.3109/08958378.2010.548838.


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