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Items: 18

1.

Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics.

Sato M, Toshimoto K, Tomaru A, Yoshikado T, Tanaka Y, Hisaka A, Lee W, Sugiyama Y.

Drug Metab Dispos. 2018 May;46(5):740-748. doi: 10.1124/dmd.117.078972. Epub 2018 Feb 23.

PMID:
29475833
2.

Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin.

Futatsugi A, Toshimoto K, Yoshikado T, Sugiyama Y, Kato Y.

Drug Metab Dispos. 2018 May;46(5):749-757. doi: 10.1124/dmd.117.078816. Epub 2018 Feb 12.

PMID:
29440178
3.

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers.

Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.

Pharm Res. 2017 Aug;34(8):1601-1614. doi: 10.1007/s11095-017-2184-5. Epub 2017 May 26.

PMID:
28550384
4.
5.

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.

Yoshikado T, Maeda K, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Kusuhara H, Furihata KI, Sugiyama Y.

Pharm Res. 2017 Aug;34(8):1570-1583. doi: 10.1007/s11095-017-2168-5. Epub 2017 May 8.

PMID:
28484975
6.

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

Kim SJ, Toshimoto K, Yao Y, Yoshikado T, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2715-2726. doi: 10.1016/j.xphs.2017.04.063. Epub 2017 May 4.

PMID:
28479356
7.

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins.

Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.

Drug Metab Dispos. 2017 Jul;45(7):779-789. doi: 10.1124/dmd.116.074823. Epub 2017 May 3.

PMID:
28468836
8.

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.

Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2688-2694. doi: 10.1016/j.xphs.2017.03.010. Epub 2017 Mar 18.

PMID:
28322941
9.

Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.

Kim SJ, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2016 Oct;44(10):1622-32. doi: 10.1124/dmd.116.070276. Epub 2016 Jul 25.

10.

Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.

Yoshikado T, Yoshida K, Kotani N, Nakada T, Asaumi R, Toshimoto K, Maeda K, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2016 Nov;100(5):513-523. doi: 10.1002/cpt.391. Epub 2016 Jul 28.

PMID:
27170342
11.

[Transporters and molecular-targeted drugs].

Yoshikado T, Sugiyama Y.

Nihon Rinsho. 2012 Nov;70 Suppl 8:688-94. Japanese. No abstract available.

PMID:
23513922
12.
13.

Ursodeoxycholic acid stimulates the formation of the bile canalicular network.

Ikebuchi Y, Shimizu H, Ito K, Yoshikado T, Yamanashi Y, Takada T, Suzuki H.

Biochem Pharmacol. 2012 Oct 1;84(7):925-35. doi: 10.1016/j.bcp.2012.07.008. Epub 2012 Jul 20.

PMID:
22820248
14.

NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.

Yamanashi Y, Takada T, Yoshikado T, Shoda J, Suzuki H.

Gastroenterology. 2011 May;140(5):1664-74. doi: 10.1053/j.gastro.2011.01.050. Epub 2011 Mar 21.

PMID:
21315718
15.

Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.

Yoshikado T, Takada T, Yamamoto T, Yamaji H, Ito K, Santa T, Yokota H, Yatomi Y, Yoshida H, Goto J, Tsuji S, Suzuki H.

Mol Pharmacol. 2011 Feb;79(2):241-50. doi: 10.1124/mol.110.067256. Epub 2010 Nov 5.

16.

Compounds having thiourea moiety as derivatization reagents in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS): synthesis of derivatization reagents for carboxylic acids.

Inoda H, Nishiyama T, Yoshikado T, Suwanai Y, Santa T.

Biomed Chromatogr. 2011 Jun;25(6):635-40. doi: 10.1002/bmc.1501. Epub 2010 Sep 1.

PMID:
20812201
17.

Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.

Ikebuchi Y, Takada T, Ito K, Yoshikado T, Anzai N, Kanai Y, Suzuki H.

Hepatol Res. 2009 Nov;39(11):1091-107. doi: 10.1111/j.1872-034X.2009.00544.x. Epub 2009 Aug 6.

PMID:
19674157
18.

Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS).

Santa T, Al-Dirbashi OY, Yoshikado T, Fukushima T, Imai K.

Biomed Chromatogr. 2009 Apr;23(4):443-6. doi: 10.1002/bmc.1124.

PMID:
19016225

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