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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Korenblat P, Kerwin E, Leshchenko I, Yen K, Holweg CTJ, Anzures-Cabrera J, Martin C, Putnam WS, Governale L, Olsson J, Matthews JG.

Respir Med. 2018 Jan;134:143-149. doi: 10.1016/j.rmed.2017.12.006. Epub 2017 Dec 13.


JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, Nagaraja R, Yen K, Teruya-Feldstein J, Wong KK, Rampal R, Heiden MGV, Thompson CB, Levine RL.

J Clin Invest. 2018 Feb 1;128(2):789-804. doi: 10.1172/JCI94516. Epub 2018 Jan 22.


Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE).

Simpson EL, Flohr C, Eichenfield LF, Bieber T, Sofen H, Taïeb A, Owen R, Putnam W, Castro M, DeBusk K, Lin CY, Voulgari A, Yen K, Omachi TA.

J Am Acad Dermatol. 2018 Jan 17. pii: S0190-9622(18)30102-6. doi: 10.1016/j.jaad.2018.01.017. [Epub ahead of print]


Associations of Tumor PD-1 Ligands, Immunohistochemical Studies, and Textural Features in 18F-FDG PET in Squamous Cell Carcinoma of the Head and Neck.

Chen RY, Lin YC, Shen WC, Hsieh TC, Yen KY, Chen SW, Kao CH.

Sci Rep. 2018 Jan 8;8(1):105. doi: 10.1038/s41598-017-18489-2.


Dipeptidyl peptidase-4 inhibitor decreases the risk of atrial fibrillation in patients with type 2 diabetes: a nationwide cohort study in Taiwan.

Chang CY, Yeh YH, Chan YH, Liu JR, Chang SH, Lee HF, Wu LS, Yen KC, Kuo CT, See LC.

Cardiovasc Diabetol. 2017 Dec 19;16(1):159. doi: 10.1186/s12933-017-0640-5.


Knowledge, competencies and attitudes regarding external post-mortem physical examination: A survey among German post-graduate trainees in general practice.

Valentini J, Goetz K, Yen K, Szecsenyi J, Dettling A, Joos S, Steinhaeuser J, Flum E.

Eur J Gen Pract. 2018 Dec;24(1):26-31. doi: 10.1080/13814788.2017.1389884. Epub 2017 Nov 23.


Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer.

Chen RY, Lin YC, Chen SW, Lin TY, Hsieh TC, Yen KY, Liang JA, Yang SN, Wang YC, Chen YH, Chiang SF, Kao CH.

Oncotarget. 2017 Aug 21;8(42):72342-72351. doi: 10.18632/oncotarget.20374. eCollection 2017 Sep 22.


Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment.

Kim SJ, Xiao J, Cohen P, Yen K.

J Vis Exp. 2017 Sep 25;(127). doi: 10.3791/56496.


The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.

Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R.

Sci Rep. 2017 Aug 10;7(1):7802. doi: 10.1038/s41598-017-08372-5.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS.

Blood. 2017 Aug 10;130(6):722-731. doi: 10.1182/blood-2017-04-779405. Epub 2017 Jun 6.


Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.

Amatangelo MD, Quek L, Shih A, Stein EM, Roshal M, David MD, Marteyn B, Farnoud NR, de Botton S, Bernard OA, Wu B, Yen KE, Tallman MS, Papaemmanuil E, Penard-Lacronique V, Thakurta A, Vyas P, Levine RL.

Blood. 2017 Aug 10;130(6):732-741. doi: 10.1182/blood-2017-04-779447. Epub 2017 Jun 6.


Mitochondrially derived peptides as novel regulators of metabolism.

Kim SJ, Xiao J, Wan J, Cohen P, Yen K.

J Physiol. 2017 Nov 1;595(21):6613-6621. doi: 10.1113/JP274472. Epub 2017 Jul 18.


Characteristics of Anterior Lens Opacities in Children.

Dixit L, Puente M, Yen KG.

Open Ophthalmol J. 2017 Apr 28;11:84-88. doi: 10.2174/1874364101711010084. eCollection 2017.


Outcomes of Cataract Surgery in Children with Down Syndrome.

Saifee M, Kong L, Yen KG.

J Ophthalmic Vis Res. 2017 Apr-Jun;12(2):243-244. doi: 10.4103/jovr.jovr_212_16. No abstract available.


Long-term Outcomes of Primary Intraocular Lens Implantation in Patients Aged 7 to 24 Months.

Yeh AG, Kong L, Yen KG.

J Pediatr Ophthalmol Strabismus. 2017 May 1;54(3):149-155. doi: 10.3928/01913913-20170206-02.


Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms.

Brubaker WD, Crane A, Johansson JU, Yen K, Garfinkel K, Mastroeni D, Asok P, Bradt B, Sabbagh M, Wallace TL, Glavis-Bloom C, Tenner AJ, Rogers J.

Alzheimers Dement. 2017 Dec;13(12):1397-1409. doi: 10.1016/j.jalz.2017.03.010. Epub 2017 May 2.


Visual outcomes of patients presenting with bilateral infantile cataracts and nystagmus.

Crockett C, Camero KA, Kong L, Yen KG.

Can J Ophthalmol. 2017 Apr;52(2):203-206. doi: 10.1016/j.jcjo.2016.08.021. Epub 2016 Oct 27.


[18]Fluorodeoxyglucose Positron Emission Tomography for the Textural Features of Cervical Cancer Associated with Lymph Node Metastasis and Histological Type.

Shen WC, Chen SW, Liang JA, Hsieh TC, Yen KY, Kao CH.

Eur J Nucl Med Mol Imaging. 2017 Sep;44(10):1721-1731. doi: 10.1007/s00259-017-3697-1. Epub 2017 Apr 14.


Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection.

Jin HD, Demmler-Harrison GJ, Coats DK, Paysse EA, Bhatt A, Edmond JC, Yen KG, Steinkuller P, Miller J; Congenital CMV Longitudinal Study Group.

Pediatr Infect Dis J. 2017 Sep;36(9):877-882. doi: 10.1097/INF.0000000000001599.


A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML.

Kats LM, Vervoort SJ, Cole R, Rogers AJ, Gregory GP, Vidacs E, Li J, Nagaraja R, Yen KE, Johnstone RW.

Leukemia. 2017 Jun;31(6):1466-1470. doi: 10.1038/leu.2017.84. Epub 2017 Mar 10. No abstract available.


Detection and volume estimation of artificial hematomas in the subcutaneous fatty tissue: comparison of different MR sequences at 3.0 T.

Ogris K, Petrovic A, Scheicher S, Sprenger H, Urschler M, Hassler EM, Yen K, Scheurer E.

Forensic Sci Med Pathol. 2017 Jun;13(2):135-144. doi: 10.1007/s12024-017-9847-8. Epub 2017 Mar 1.


Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer AM, Nazir A, Stein EM, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason CE, Yen K, Thompson CB, Melnick A, Levine RL.

Cancer Discov. 2017 May;7(5):494-505. doi: 10.1158/2159-8290.CD-16-1049. Epub 2017 Feb 13.


AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Yen K, Travins J, Wang F, David MD, Artin E, Straley K, Padyana A, Gross S, DeLaBarre B, Tobin E, Chen Y, Nagaraja R, Choe S, Jin L, Konteatis Z, Cianchetta G, Saunders JO, Salituro FG, Quivoron C, Opolon P, Bawa O, Saada V, Paci A, Broutin S, Bernard OA, de Botton S, Marteyn BS, Pilichowska M, Xu Y, Fang C, Jiang F, Wei W, Jin S, Silverman L, Liu W, Yang H, Dang L, Dorsch M, Penard-Lacronique V, Biller SA, Su SM.

Cancer Discov. 2017 May;7(5):478-493. doi: 10.1158/2159-8290.CD-16-1034. Epub 2017 Feb 13.


Predictive Value of 18F-FDG PET/CT for Vascular Invasion in Patients With Hepatocellular Carcinoma Before Liver Transplantation.

Lin CY, Liao CW, Chu LY, Yen KY, Jeng LB, Hsu CN, Lin CL, Kao CH.

Clin Nucl Med. 2017 Apr;42(4):e183-e187. doi: 10.1097/RLU.0000000000001545.


Correlation of pretreatment 18F-FDG PET tumor textural features with gene expression in pharyngeal cancer and implications for radiotherapy-based treatment outcomes.

Chen SW, Shen WC, Lin YC, Chen RY, Hsieh TC, Yen KY, Kao CH.

Eur J Nucl Med Mol Imaging. 2017 Apr;44(4):567-580. doi: 10.1007/s00259-016-3580-5. Epub 2016 Dec 20.


The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.

Lemonnier F, Cairns RA, Inoue S, Li WY, Dupuy A, Broutin S, Martin N, Fataccioli V, Pelletier R, Wakeham A, Snow BE, de Leval L, Pujals A, Haioun C, Paci A, Tobin ER, Narayanaswamy R, Yen K, Jin S, Gaulard P, Mak TW.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15084-15089. doi: 10.1073/pnas.1617929114. Epub 2016 Dec 12.


Neural adaptive observer-based sensor and actuator fault detection in nonlinear systems: Application in UAV.

Abbaspour A, Aboutalebi P, Yen KK, Sargolzaei A.

ISA Trans. 2017 Mar;67:317-329. doi: 10.1016/j.isatra.2016.11.005. Epub 2016 Nov 24.


Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation.

Hsu YC, Coumar MS, Wang WC, Shiao HY, Ke YY, Lin WH, Kuo CC, Chang CW, Kuo FM, Chen PY, Wang SY, Li AS, Chen CH, Kuo PC, Chen CP, Wu MH, Huang CL, Yen KJ, Chang YI, Hsu JT, Chen CT, Yeh TK, Song JS, Shih C, Hsieh HP.

Oncotarget. 2016 Dec 27;7(52):86239-86256. doi: 10.18632/oncotarget.13369.


Treating hepatocellular carcinoma with 90Y-bearing microspheres: a review.

Hsieh TC, Wu YC, Sun SS, Yen KY, Kao CH.

Biomedicine (Taipei). 2016 Nov;6(4):19. Epub 2016 Nov 16.


The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6.

Van Oss SB, Shirra MK, Bataille AR, Wier AD, Yen K, Vinayachandran V, Byeon IL, Cucinotta CE, Héroux A, Jeon J, Kim J, VanDemark AP, Pugh BF, Arndt KM.

Mol Cell. 2016 Nov 17;64(4):815-825. doi: 10.1016/j.molcel.2016.10.008. Epub 2016 Nov 10.


Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer.

Chen SW, Lin YC, Chen RY, Hsieh TC, Yen KY, Liang JA, Yang SN, Wang YC, Chen YH, Chow NH, Kao CH.

Eur J Nucl Med Mol Imaging. 2016 Dec;43(13):2343-2352. Epub 2016 Jun 16.


Cataract Surgery in Children from Birth to Less than 13 Years of Age: Baseline Characteristics of the Cohort.

Repka MX, Dean TW, Lazar EL, Yen KG, Lenhart PD, Freedman SF, Hug D, Rahmani B, Wang SX, Kraker RT, Wallace DK; Pediatric Eye Disease Investigator Group.

Ophthalmology. 2016 Dec;123(12):2462-2473. doi: 10.1016/j.ophtha.2016.09.003. Epub 2016 Oct 18.


Immunohistochemical studies and fluorodeoxyglucose uptake on positron emission tomography in pharyngeal cancer for predicting radiotherapy-based treatment outcomes.

Lin YC, Chen RY, Chen SW, Hsieh TC, Yen KY, Liang JA, Yang SN, Wang YC, Chen YH, Chow NH, Kao CH.

Clin Otolaryngol. 2017 Jun;42(3):608-619. doi: 10.1111/coa.12783. Epub 2016 Nov 14.


Essentials of Pediatric Emergency Medicine Fellowship: Part 6: Program Administration.

Kim IK, Zuckerbraun N, Kou M, Vu T, Levasseur K, Yen K, Chapman J, Doughty C, McAneney C, Zaveri P, Hsu D; PEM Fellowship Directorsʼ Writing Group.

Pediatr Emerg Care. 2016 Oct;32(10):726-730.


Essentials of PEM Fellowship: Part 5: Scholarship Prepares Fellows to Lead as Pediatric Emergency Specialists.

Reynolds S, Chang T, Iyer S, Mann C, Wilkinson M, Yen K, Schnadower D; PEM Fellowship Directors’ Writing Group.

Pediatr Emerg Care. 2016 Sep;32(9):645-7. doi: 10.1097/PEC.0000000000000896.


A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.

Wang F, Travins J, Lin Z, Si Y, Chen Y, Powe J, Murray S, Zhu D, Artin E, Gross S, Santiago S, Steadman M, Kernytsky A, Straley K, Lu C, Pop A, Struys EA, Jansen EE, Salomons GS, David MD, Quivoron C, Penard-Lacronique V, Regan KS, Liu W, Dang L, Yang H, Silverman L, Agresta S, Dorsch M, Biller S, Yen K, Cang Y, Su SM, Jin S.

J Inherit Metab Dis. 2016 Nov;39(6):807-820. Epub 2016 Jul 28.


Dynamic analysis of the human brain with complex cerebral sulci.

Tseng JG, Huang BW, Ou YW, Yen KT, Wu YT.

Bioengineered. 2016 Jul 3;7(4):219-25. doi: 10.1080/21655979.2016.1197591.


c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish.

Liu W, Wu M, Huang Z, Lian J, Chen J, Wang T, Leung AY, Liao Y, Zhang Z, Liu Q, Yen K, Lin S, Zon LI, Wen Z, Zhang Y, Zhang W.

Leukemia. 2017 Jan;31(1):222-233. doi: 10.1038/leu.2016.170. Epub 2016 Jun 14.


Sensorimotor control: computing the immediate future from the delayed present.

Sargolzaei A, Abdelghani M, Yen KK, Sargolzaei S.

BMC Bioinformatics. 2016 Jul 25;17 Suppl 7:245. doi: 10.1186/s12859-016-1098-2.


New bone post-processing tools in forensic imaging: a multi-reader feasibility study to evaluate detection time and diagnostic accuracy in rib fracture assessment.

Glemser PA, Pfleiderer M, Heger A, Tremper J, Krauskopf A, Schlemmer HP, Yen K, Simons D.

Int J Legal Med. 2017 Mar;131(2):489-496. doi: 10.1007/s00414-016-1412-6. Epub 2016 Jul 22.


Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

Cancer Cell. 2016 Aug 8;30(2):337-348. doi: 10.1016/j.ccell.2016.05.018. Epub 2016 Jul 14.


Zosteriform Secondary Cutaneous Diffuse Large B-Cell Lymphoma on FDG PET/CT.

Liao CW, Yen KY, Hsieh TC, Kao CH.

Clin Nucl Med. 2016 Sep;41(9):701-2. doi: 10.1097/RLU.0000000000001287.


The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.

Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K.

Oncotarget. 2016 Jul 26;7(30):46899-46912. doi: 10.18632/oncotarget.10380.


Applicability of Greulich-Pyle and Tanner-Whitehouse grading methods to MRI when assessing hand bone age in forensic age estimation: A pilot study.

Urschler M, Krauskopf A, Widek T, Sorantin E, Ehammer T, Borkenstein M, Yen K, Scheurer E.

Forensic Sci Int. 2016 Sep;266:281-288. doi: 10.1016/j.forsciint.2016.06.016. Epub 2016 Jun 17.


Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.

Aguilar-Gurrieri C, Larabi A, Vinayachandran V, Patel NA, Yen K, Reja R, Ebong IO, Schoehn G, Robinson CV, Pugh BF, Panne D.

EMBO J. 2016 Jul 1;35(13):1465-82. doi: 10.15252/embj.201694105. Epub 2016 May 25.


Humanin: Functional Interfaces with IGF-I.

Xiao J, Kim SJ, Cohen P, Yen K.

Growth Horm IGF Res. 2016 Aug;29:21-27. doi: 10.1016/j.ghir.2016.03.005. Epub 2016 Apr 7. Review.


Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P.

Aging (Albany NY). 2016 Apr;8(4):796-809. doi: 10.18632/aging.100943.


The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit.

Li Q, Guan X, Yen K, Zhang J, Yan J.

J Gen Physiol. 2016 Apr;147(4):337-51. doi: 10.1085/jgp.201511551.


IDH mutations in cancer and progress toward development of targeted therapeutics.

Dang L, Yen K, Attar EC.

Ann Oncol. 2016 Apr;27(4):599-608. doi: 10.1093/annonc/mdw013. Review.


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