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Items: 28


Altered gut microbiome and metabolome in patients with multiple system atrophy.

Tan AH, Chong CW, Song SL, Teh CSJ, Yap IKS, Loke MF, Tan YQ, Yong HS, Mahadeva S, Lang AE, Lim SY.

Mov Disord. 2018 Jan;33(1):174-176. doi: 10.1002/mds.27203. Epub 2017 Oct 30. No abstract available.


Pneumococcal conjugate vaccine implementation in middle-income countries.

Tricarico S, McNeil HC, Cleary DW, Head MG, Lim V, Yap IKS, Wie CC, Tan CS, Norazmi MN, Aziah I, Cheah ESG, Faust SN, Jefferies JMC, Roderick PJ, Moore M, Yuen HM, Newell ML, McGrath N, Doncaster CP, Kraaijeveld AR, Webb JS, Clarke SC.

Pneumonia (Nathan). 2017 Mar 25;9:6. doi: 10.1186/s41479-017-0030-5. eCollection 2017. Review.


Intestinal carriage of multidrug-resistant gram-negative bacteria in preterm-infants during hospitalization in neonatal intensive care unit (NICU).

Yap PS, Ahmad Kamar A, Chong CW, Yap IK, Thong KL, Choo YM, Md Yusof MY, Teh CS.

Pathog Glob Health. 2016 Sep;110(6):238-246. Epub 2016 Sep 21.


Prevalence and risk factors of intestinal parasitism among two indigenous sub-ethnic groups in Peninsular Malaysia.

Chin YT, Lim YA, Chong CW, Teh CS, Yap IK, Lee SC, Tee MZ, Siow VW, Chua KH.

Infect Dis Poverty. 2016 Jul 18;5(1):77. doi: 10.1186/s40249-016-0168-z.


Targeting Heat Shock Proteins 60 and 70 of Toxoplasma gondii as a Potential Drug Target: In Silico Approach.

Ashwinder K, Kho MT, Chee PM, Lim WZ, Yap IK, Choi SB, Yam WK.

Interdiscip Sci. 2016 Dec;8(4):374-387. Epub 2015 Aug 22.


Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia.

Chong CW, Ahmad AF, Lim YA, Teh CS, Yap IK, Lee SC, Chin YT, Loke P, Chua KH.

Sci Rep. 2015 Aug 20;5:13338. doi: 10.1038/srep13338.


Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).

Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO.

Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191.


Field evaluation of a rapid diagnostic test to detect antibodies in human toxocariasis.

Lim PK, Yamasaki H, Mak JW, Wong SF, Chong CW, Yap IK, Ambu S, Kumarasamy V.

Acta Trop. 2015 Aug;148:32-7. doi: 10.1016/j.actatropica.2015.04.011. Epub 2015 Apr 22.


Acclimatisation-induced stress influenced host metabolic and gut microbial composition change.

Yap IK, Kho MT, Lim SH, Ismail NH, Yam WK, Chong CW.

Mol Biosyst. 2015 Jan;11(1):297-306. doi: 10.1039/c4mb00463a. Epub 2014 Nov 10.


Metabonomic investigations of age- and batch-related variations in female NMRI mice using proton nuclear magnetic resonance spectroscopy.

Li JV, Saric J, Yap IK, Utzinger J, Holmes E.

Mol Biosyst. 2013 Dec;9(12):3155-65. doi: 10.1039/c3mb70215d. Epub 2013 Oct 11.


Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure.

Stamler J, Brown IJ, Yap IK, Chan Q, Wijeyesekera A, Garcia-Perez I, Chadeau-Hyam M, Ebbels TM, De Iorio M, Posma J, Daviglus ML, Carnethon M, Holmes E, Nicholson JK, Elliott P; INTERMAP Research Group.

Hypertension. 2013 Dec;62(6):1074-80. doi: 10.1161/HYPERTENSIONAHA.113.01810. Epub 2013 Oct 7.


Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.

Wijeyesekera A, Clarke PA, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IK, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JK.

Anal Methods. 2012 Jan 1;4(1):65-72.


Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant.

Thomas EL, Parkinson JR, Hyde MJ, Yap IK, Holmes E, Doré CJ, Bell JD, Modi N.

Pediatr Res. 2011 Nov;70(5):507-12. doi: 10.1203/PDR.0b013e31822d7860.


Global metabolic phenotyping in an experimental laparotomy model of surgical trauma.

Kinross JM, Alkhamesi N, Barton RH, Silk DB, Yap IK, Darzi AW, Holmes E, Nicholson JK.

J Proteome Res. 2011 Jan 7;10(1):277-87. doi: 10.1021/pr1003278. Epub 2010 Nov 24.


Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.

Yap IK, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels T, De Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E.

J Proteome Res. 2010 Dec 3;9(12):6647-54. doi: 10.1021/pr100798r. Epub 2010 Nov 2.


Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls.

Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK.

J Proteome Res. 2010 Jun 4;9(6):2996-3004. doi: 10.1021/pr901188e.


Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.

Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P.

J Clin Epidemiol. 2010 Sep;63(9):970-9. doi: 10.1016/j.jclinepi.2009.10.001. Epub 2010 Jan 8. Review.


Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.

Martin FP, Wang Y, Yap IK, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Holmes E, Nicholson JK.

J Proteome Res. 2009 Jul;8(7):3464-74. doi: 10.1021/pr900099x.


Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.

Saric J, Li JV, Wang Y, Keiser J, Veselkov K, Dirnhofer S, Yap IK, Nicholson JK, Holmes E, Utzinger J.

J Proteome Res. 2009 Aug;8(8):3899-911. doi: 10.1021/pr900185s.


Panorganismal gut microbiome-host metabolic crosstalk.

Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon JC, Holmes E, Nicholson JK.

J Proteome Res. 2009 Apr;8(4):2090-105. doi: 10.1021/pr801068x.


Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse.

Yap IK, Li JV, Saric J, Martin FP, Davies H, Wang Y, Wilson ID, Nicholson JK, Utzinger J, Marchesi JR, Holmes E.

J Proteome Res. 2008 Sep;7(9):3718-28. doi: 10.1021/pr700864x. Epub 2008 Aug 13.


Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.

Martin FP, Wang Y, Sprenger N, Yap IK, Rezzi S, Ramadan Z, Peré-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK.

Mol Syst Biol. 2008;4:205. doi: 10.1038/msb.2008.40. Epub 2008 Jul 15.


Human metabolic phenotype diversity and its association with diet and blood pressure.

Holmes E, Loo RL, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P.

Nature. 2008 May 15;453(7193):396-400. doi: 10.1038/nature06882. Epub 2008 Apr 20.


Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.

Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK.

Mol Syst Biol. 2008;4:157. doi: 10.1038/msb4100190. Epub 2008 Jan 15.


Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

Skordi E, Yap IK, Claus SP, Martin FP, Cloarec O, Lindberg J, Schuppe-Koistinen I, Holmes E, Nicholson JK.

J Proteome Res. 2007 Dec;6(12):4572-81. Epub 2007 Oct 30.


A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.

Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IK, Tang H, Zirah S, Murphy GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P, Holmes E, Nicholson JK.

Mol Syst Biol. 2007;3:112. Epub 2007 May 22.


An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate.

Yap IK, Clayton TA, Tang H, Everett JR, Hanton G, Provost JP, Le Net JL, Charuel C, Lindon JC, Nicholson JK.

J Proteome Res. 2006 Oct;5(10):2675-84.


Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.

Martin FP, Verdu EF, Wang Y, Dumas ME, Yap IK, Cloarec O, Bergonzelli GE, Corthesy-Theulaz I, Kochhar S, Holmes E, Lindon JC, Collins SM, Nicholson JK.

J Proteome Res. 2006 Sep;5(9):2185-93.


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