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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K.

J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6.


Notching a New Pathway in Vascular Flow Sensing.

Lagendijk AK, Yap AS, Hogan BM.

Trends Cell Biol. 2018 Mar;28(3):173-175. doi: 10.1016/j.tcb.2017.12.003. Epub 2018 Jan 2.


Author Correction: Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.

Liang X, Budnar S, Gupta S, Verma S, Han SP, Hill MM, Daly RJ, Parton RG, Hamilton NA, Gomez GA, Yap AS.

Nat Commun. 2017 Dec 5;8(1):2021. doi: 10.1038/s41467-017-02131-w.


Versatile Scaffold: Extrajunctional Roles for α-Catenin.

Budnar S, Yap AS.

Dev Cell. 2017 Nov 20;43(4):381-382. doi: 10.1016/j.devcel.2017.11.004. Review.


Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.

Liang X, Kiru S, Gomez GA, Yap AS.

Cytoskeleton (Hoboken). 2018 Feb;75(2):61-69. doi: 10.1002/cm.21420. Epub 2017 Dec 5.


Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.

Lagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM.

Nat Commun. 2017 Nov 10;8(1):1402. doi: 10.1038/s41467-017-01325-6.


Role of contact inhibition of locomotion and junctional mechanics in epithelial collective responses to injury.

Coburn L, Lopez H, Schouwenaar IM, Yap AS, Lobaskin V, Gomez GA.

Phys Biol. 2018 Jan 25;15(2):024001. doi: 10.1088/1478-3975/aa976b.


Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.

Liang X, Budnar S, Gupta S, Verma S, Han SP, Hill MM, Daly RJ, Parton RG, Hamilton NA, Gomez GA, Yap AS.

Nat Commun. 2017 Oct 5;8(1):790. doi: 10.1038/s41467-017-00797-w. Erratum in: Nat Commun. 2017 Dec 5;8(1):2021.


Mechanosensing and Mechanotransduction at Cell-Cell Junctions.

Yap AS, Duszyc K, Viasnoff V.

Cold Spring Harb Perspect Biol. 2017 Aug 4. pii: a028761. doi: 10.1101/cshperspect.a028761. [Epub ahead of print]


In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.

Duszyc K, Gomez GA, Schroder K, Sweet MJ, Yap AS.

Tissue Barriers. 2017 Oct 2;5(4):e1345353. doi: 10.1080/21688370.2017.1345353. Epub 2017 Jul 7.


Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development.

Lim YW, Lo HP, Ferguson C, Martel N, Giacomotto J, Gomez GA, Yap AS, Hall TE, Parton RG.

Curr Biol. 2017 Jul 10;27(13):1968-1981.e7. doi: 10.1016/j.cub.2017.05.067. Epub 2017 Jun 22.


Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility.

Acharya BR, Wu SK, Lieu ZZ, Parton RG, Grill SW, Bershadsky AD, Gomez GA, Yap AS.

Cell Rep. 2017 Mar 21;18(12):2854-2867. doi: 10.1016/j.celrep.2017.02.078.


Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.

Kerr MC, Gomez GA, Ferguson C, Tanzer MC, Murphy JM, Yap AS, Parton RG, Huston WM, Teasdale RD.

Nat Commun. 2017 Mar 10;8:14729. doi: 10.1038/ncomms14729.


Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions.

Priya R, Gomez GA, Budnar S, Acharya BR, Czirok A, Yap AS, Neufeld Z.

PLoS Comput Biol. 2017 Mar 8;13(3):e1005411. doi: 10.1371/journal.pcbi.1005411. eCollection 2017 Mar.


Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Feb 27;40(4):421. doi: 10.1016/j.devcel.2017.02.005. No abstract available.


Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Jan 23;40(2):123-136. doi: 10.1016/j.devcel.2016.12.017.


ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.

Priya R, Liang X, Teo JL, Duszyc K, Yap AS, Gomez GA.

Mol Biol Cell. 2017 Jan 1;28(1):12-20. doi: 10.1091/mbc.E16-04-0262. Epub 2016 Nov 9.


Editorial overview: Membrane traffic and cell polarity.

Bryant DM, Yap AS.

Traffic. 2016 Dec;17(12):1231-1232. doi: 10.1111/tra.12433. No abstract available.


Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates.

Coburn L, Lopez H, Caldwell BJ, Moussa E, Yap C, Priya R, Noppe A, Roberts AP, Lobaskin V, Yap AS, Neufeld Z, Gomez GA.

Mol Biol Cell. 2016 Nov 7;27(22):3436-3448. Epub 2016 Sep 7.


Targeted Genome Editing via CRISPR in the Pathogen Cryptococcus neoformans.

Arras SD, Chua SM, Wizrah MS, Faint JA, Yap AS, Fraser JA.

PLoS One. 2016 Oct 6;11(10):e0164322. doi: 10.1371/journal.pone.0164322. eCollection 2016.


Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.

Priya R, Wee K, Budnar S, Gomez GA, Yap AS, Michael M.

Cell Cycle. 2016 Nov 16;15(22):3033-3041. Epub 2016 Sep 20.


Cycling Rho for tissue contraction.

Teo JL, Yap AS.

J Cell Biol. 2016 Aug 29;214(5):495-8. doi: 10.1083/jcb.201608017. Epub 2016 Aug 22.


Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling.

Humphrey ES, Su SP, Nagrial AM, Hochgräfe F, Pajic M, Lehrbach GM, Parton RG, Yap AS, Horvath LG, Chang DK, Biankin AV, Wu J, Daly RJ.

Mol Cell Proteomics. 2016 Aug;15(8):2671-85. doi: 10.1074/mcp.M116.058313. Epub 2016 Jun 3.


The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y.

Cancer Res. 2016 Jul 15;76(14):4236-48. doi: 10.1158/0008-5472.CAN-15-1553. Epub 2016 May 26.


The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis.

Oh TG, Wang SM, Acharya BR, Goode JM, Graham JD, Clarke CL, Yap AS, Muscat GEO.

EBioMedicine. 2016 Apr;6:59-72. doi: 10.1016/j.ebiom.2016.02.028. Epub 2016 Feb 18.


Remodeling the zonula adherens in response to tension and the role of afadin in this response.

Choi W, Acharya BR, Peyret G, Fardin MA, Mège RM, Ladoux B, Yap AS, Fanning AS, Peifer M.

J Cell Biol. 2016 Apr 25;213(2):243-60. doi: 10.1083/jcb.201506115.


Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions.

Michael M, Meiring JCM, Acharya BR, Matthews DR, Verma S, Han SP, Hill MM, Parton RG, Gomez GA, Yap AS.

Dev Cell. 2016 Apr 4;37(1):58-71. doi: 10.1016/j.devcel.2016.03.008.


Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension.

Lee NK, Fok KW, White A, Wilson NH, O'Leary CJ, Cox HL, Michael M, Yap AS, Cooper HM.

Nat Commun. 2016 Mar 31;7:11082. doi: 10.1038/ncomms11082.


Pli Selon Pli: Mechanochemical Feedback and the Morphogenetic Role of Contractility at Cadherin Cell-Cell Junctions.

Acharya BR, Yap AS.

Curr Top Dev Biol. 2016;117:631-46. doi: 10.1016/bs.ctdb.2015.10.021. Epub 2016 Jan 7. Review.


Biomechanical guidance helps elongate a lumen.

Wee K, Yap AS.

Nat Cell Biol. 2016 Mar;18(3):255-7. doi: 10.1038/ncb3319.


Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish.

Koltowska K, Lagendijk AK, Pichol-Thievend C, Fischer JC, Francois M, Ober EA, Yap AS, Hogan BM.

Cell Rep. 2015 Dec 1;13(9):1828-41. doi: 10.1016/j.celrep.2015.10.055. Epub 2015 Nov 19.


Mammalian farnesyltransferase α subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)--dependent intracellular trafficking through recycling endosomes.

Kubala MH, Norwood SJ, Gomez GA, Jones A, Johnston W, Yap AS, Mureev S, Alexandrov K.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):580-6. doi: 10.1016/j.bbrc.2015.10.148. Epub 2015 Nov 10.


Seeing and believing: recent advances in imaging cell-cell interactions.

Yap AS, Michael M, Parton RG.

F1000Res. 2015 Jul 17;4(F1000 Faculty Rev):273. doi: 10.12688/f1000research.6435.1. eCollection 2015. Review.


Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.

Hoffman BD, Yap AS.

Trends Cell Biol. 2015 Dec;25(12):803-14. doi: 10.1016/j.tcb.2015.09.008. Epub 2015 Oct 28. Review.


Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies.

Yap AS, Gomez GA, Parton RG.

Dev Cell. 2015 Oct 12;35(1):12-20. doi: 10.1016/j.devcel.2015.09.012. Review.


Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.

Priya R, Gomez GA, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS.

Nat Cell Biol. 2015 Oct;17(10):1282-93. doi: 10.1038/ncb3239. Epub 2015 Sep 14.


Making a Choice: How Cadherin Switching Controls Cell Migration.

Priya R, Yap AS.

Dev Cell. 2015 Aug 24;34(4):383-4. doi: 10.1016/j.devcel.2015.08.002.


Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization.

Greenlees R, Mihelec M, Yousoof S, Speidel D, Wu SK, Rinkwitz S, Prokudin I, Perveen R, Cheng A, Ma A, Nash B, Gillespie R, Loebel DA, Clayton-Smith J, Lloyd IC, Grigg JR, Tam PP, Yap AS, Becker TS, Black GC, Semina E, Jamieson RV.

Hum Mol Genet. 2015 Oct 15;24(20):5789-804. doi: 10.1093/hmg/ddv298. Epub 2015 Jul 30.


Modelling wound closure in an epithelial cell sheet using the cellular Potts model.

Noppe AR, Roberts AP, Yap AS, Gomez GA, Neufeld Z.

Integr Biol (Camb). 2015 Oct;7(10):1253-64. doi: 10.1039/c5ib00053j. Epub 2015 Jun 29.


E-cadherin junctions as active mechanical integrators in tissue dynamics.

Lecuit T, Yap AS.

Nat Cell Biol. 2015 May;17(5):533-9. doi: 10.1038/ncb3136. Review.


Preface. Cellular adhesion in development and disease.

Yap AS.

Curr Top Dev Biol. 2015;112:xv-xvii. doi: 10.1016/S0070-2153(15)00024-1. No abstract available.


Active tension: the role of cadherin adhesion and signaling in generating junctional contractility.

Priya R, Yap AS.

Curr Top Dev Biol. 2015;112:65-102. doi: 10.1016/bs.ctdb.2014.11.016. Epub 2015 Feb 12. Review.


Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking.

Papadopulos A, Gomez GA, Martin S, Jackson J, Gormal RS, Keating DJ, Yap AS, Meunier FA.

Nat Commun. 2015 Feb 24;6:6297. doi: 10.1038/ncomms7297.


An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.

Gomez GA, McLachlan RW, Wu SK, Caldwell BJ, Moussa E, Verma S, Bastiani M, Priya R, Parton RG, Gaus K, Sap J, Yap AS.

Mol Biol Cell. 2015 Apr 1;26(7):1249-62. doi: 10.1091/mbc.E14-07-1223. Epub 2015 Jan 28.


Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.

Wu SK, Lagendijk AK, Hogan BM, Gomez GA, Yap AS.

Cell Cycle. 2015;14(3):315-22. doi: 10.4161/15384101.2014.989127.


Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.

Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS, Gomez GA.

Cytoskeleton (Hoboken). 2014 Dec;71(12):663-76. doi: 10.1002/cm.21202. Epub 2015 Jan 31.


Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions.

Moore T, Wu SK, Michael M, Yap AS, Gomez GA, Neufeld Z.

Biophys J. 2014 Dec 2;107(11):2652-61. doi: 10.1016/j.bpj.2014.10.045. Epub 2014 Dec 2.


Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions.

Wu SK, Budnar S, Yap AS, Gomez GA.

Eur J Cell Biol. 2014 Oct;93(10-12):396-404. doi: 10.1016/j.ejcb.2014.09.001. Epub 2014 Sep 16.


E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.

Chen A, Beetham H, Black MA, Priya R, Telford BJ, Guest J, Wiggins GA, Godwin TD, Yap AS, Guilford PJ.

BMC Cancer. 2014 Jul 30;14:552. doi: 10.1186/1471-2407-14-552.


Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion.

Bracken CP, Li X, Wright JA, Lawrence DM, Pillman KA, Salmanidis M, Anderson MA, Dredge BK, Gregory PA, Tsykin A, Neilsen C, Thomson DW, Bert AG, Leerberg JM, Yap AS, Jensen KB, Khew-Goodall Y, Goodall GJ.

EMBO J. 2014 Sep 17;33(18):2040-56. doi: 10.15252/embj.201488641. Epub 2014 Jul 28.

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