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Modified XELIRI (capecitabine plus irinotecan) versus FOLFIRI (leucovorin, fluorouracil, and irinotecan), both either with or without bevacizumab, as second-line therapy for metastatic colorectal cancer (AXEPT): a multicentre, open-label, randomised, non-inferiority, phase 3 trial.

Xu RH, Muro K, Morita S, Iwasa S, Han SW, Wang W, Kotaka M, Nakamura M, Ahn JB, Deng YH, Kato T, Cho SH, Ba Y, Matsuoka H, Lee KW, Zhang T, Yamada Y, Sakamoto J, Park YS, Kim TW.

Lancet Oncol. 2018 Mar 16. pii: S1470-2045(18)30140-2. doi: 10.1016/S1470-2045(18)30140-2. [Epub ahead of print]


Detection of exhaled carbon dioxide following intubation during resuscitation at delivery.

Hunt KA, Yamada Y, Murthy V, Srihari Bhat P, Campbell M, Fox GF, Milner AD, Greenough A.

Arch Dis Child Fetal Neonatal Ed. 2018 Mar 17. pii: fetalneonatal-2017-313982. doi: 10.1136/archdischild-2017-313982. [Epub ahead of print]


The impact of organ dysfunctions on mortality in patients with severe sepsis: A multicenter prospective observational study.

Kudo D, Kushimoto S, Miyagawa N, Sato T, Hasegawa M, Ito F, Yamanouchi S, Honda H, Andoh K, Furukawa H, Yamada Y, Tsujimoto Y, Okuyama M.

J Crit Care. 2018 Mar 7;45:178-183. doi: 10.1016/j.jcrc.2018.03.011. [Epub ahead of print]


Effects of ramelteon on cardiac injury and adipose tissue pathology in rats with metabolic syndrome.

Uchinaka A, Kawashima Y, Sano Y, Ito S, Sano Y, Nagasawa K, Matsuura N, Yoneda M, Yamada Y, Murohara T, Nagata K.

Ann N Y Acad Sci. 2018 Mar 15. doi: 10.1111/nyas.13578. [Epub ahead of print]


Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p) inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis.

Sugawara S, Yamada Y, Arai T, Okato A, Idichi T, Kato M, Koshizuka K, Ichikawa T, Seki N.

J Hum Genet. 2018 Mar 14. doi: 10.1038/s10038-018-0437-8. [Epub ahead of print]


Development of a Three-dimensional Surgical Navigation System with Magnetic Resonance Angiography and a Three-dimensional Printer for Robot-assisted Radical Prostatectomy.

Jomoto W, Tanooka M, Doi H, Kikuchi K, Mitsuie C, Yamada Y, Suzuki T, Yamano T, Ishikura R, Kotoura N, Yamamoto S.

Cureus. 2018 Jan 2;10(1):e2018. doi: 10.7759/cureus.2018.


Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets.

Arai T, Fuse M, Goto Y, Kaga K, Kurozumi A, Yamada Y, Sugawara S, Okato A, Ichikawa T, Yamanishi T, Seki N.

J Hum Genet. 2018 Mar 12. doi: 10.1038/s10038-018-0419-x. [Epub ahead of print]


Seasonal changes in anthropometric, physiological, nutritional, and performance factors in collegiate rowers.

Kuzuhara K, Katai K, Hojo T, Fujisawa Y, Kimura M, Yanagida Y, Yamada Y, Iguchi J.

J Strength Cond Res. 2018 Mar 6. doi: 10.1519/JSC.0000000000002521. [Epub ahead of print]


Evaluating activities of daily living using an infrared depth sensor: KINECTTM.

Kusunoki M, Kohama T, Yamada Y, Fujita E, Okada S, Maeda A, Takeshima N.

Disabil Rehabil Assist Technol. 2018 Mar 9:1-11. doi: 10.1080/17483107.2018.1449020. [Epub ahead of print]


A novel method for DNA methylation analysis using high-performance liquid chromatography and its clinical application.

Yotani T, Yamada Y, Arai E, Tian Y, Gotoh M, Komiyama M, Fujimoto H, Sakamoto M, Kanai Y.

Cancer Sci. 2018 Mar 9. doi: 10.1111/cas.13566. [Epub ahead of print]


Tiny Obturator Node Metastasis from Prostate Cancer Not Shown by FDG-PET/CT, CT, or MRI Detected by 11C-Choline PET/CT.

Kitajima K, Yamamoto S, Odawara S, Kawanaka Y, Nakanishi Y, Hashimoto T, Yamada Y, Suzuki T, Kanematsu A, Nojima M, Kimura N, Zouzumi M, Hirota S, Yamakado K.

Case Rep Oncol. 2018 Jan 16;11(1):33-37. doi: 10.1159/000486365. eCollection 2018 Jan-Apr.


Genome-wide discovery and identification of a novel miRNA signature for recurrence prediction in stage II and III colorectal cancer.

Kandimalla R, Gao F, Matsuyama T, Ishikawa T, Uetake H, Takahashi N, Yamada Y, Becerra CR, Kopetz S, Wang X, Goel A.

Clin Cancer Res. 2018 Mar 7. pii: clincanres.3236.2017. doi: 10.1158/1078-0432.CCR-17-3236. [Epub ahead of print]


Macromolecule-Network Electrostatics Controlling Delivery of the Biotherapeutic Cell Modulator TIMP-2.

Yamada Y, Chowdhury A, Schneider JP, Stetler-Stevenson WG.

Biomacromolecules. 2018 Mar 19. doi: 10.1021/acs.biomac.8b00107. [Epub ahead of print]


Systematic exploitation of thermotropic bicontinuous cubic phase families from 1,2-bis(aryloyl)hydrazine-based molecules.

Kutsumizu S, Yamada Y, Sugimoto T, Yamada N, Udagawa T, Miwa Y.

Phys Chem Chem Phys. 2018 Mar 2. doi: 10.1039/c7cp08345a. [Epub ahead of print]


Brain Metastases in Pancreatic Ductal Adenocarcinoma: Assessment of Molecular Genotype-Phenotype Features-An Entity With an Increasing Incidence?

Jordan EJ, Lowery MA, Basturk O, Allen PJ, Yu KH, Tabar V, Beal K, Reidy DL, Yamada Y, Janjigian Y, Abou-Alfa GK, O'Reilly EM.

Clin Colorectal Cancer. 2018 Feb 7. pii: S1533-0028(17)30290-6. doi: 10.1016/j.clcc.2018.01.009. [Epub ahead of print]


Poly(meta-phenylene oxides) for the design of a tunable, efficient, and reusable catalytic platform.

Hudson R, Zhang HR, LoTemplio A, Benedetto G, Hamasaka G, Yamada YMA, Katz JL, Uozumi Y.

Chem Commun (Camb). 2018 Mar 15;54(23):2878-2881. doi: 10.1039/c8cc00774h.


Quantitative and qualitative evaluation of hybrid iterative reconstruction, with and without noise power spectrum models: A phantom study.

Minamishima K, Sugisawa K, Yamada Y, Jinzaki M.

J Appl Clin Med Phys. 2018 Feb 28. doi: 10.1002/acm2.12304. [Epub ahead of print]


Endogenous Adenosine May Be Related to Left Ventricular Dysfunction, Dilation, and Wall Thinning in Patients With Heart Disease.

Kinomura Y, Tanaka T, Aoyama T, Hatasa M, Minatoguchi S, Iwasa M, Yamada Y, Nawa T, Kanamori H, Kawasaki M, Esaka Y, Uno B, Nishigaki K, Minatoguchi S.

Circ J. 2018 Feb 28. doi: 10.1253/circj.CJ-17-0972. [Epub ahead of print]


Method for Prediction of Efficacy of Sugammadex Administered to Recover from Rocuronium-Induced Neuromuscular Blockade in Gynecological Laparoscopic Surgery Cases.

Kimura K, Omura K, Hoshino T, Takahashi H, Imaura M, Yamada Y.

Biol Pharm Bull. 2018;41(3):312-318. doi: 10.1248/bpb.b17-00304.


High Frequency of Spread Through Air Spaces in Resected Small Cell Lung Cancer.

Toyokawa G, Yamada Y, Tagawa T, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Hirai F, Oda Y, Maehara Y.

Anticancer Res. 2018 Mar;38(3):1821-1825.


Efficacy and Safety of GPR119 Agonist DS-8500a in Japanese Patients with Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Controlled, 12-Week Study.

Yamada Y, Terauchi Y, Watada H, Nakatsuka Y, Shiosakai K, Washio T, Taguchi T.

Adv Ther. 2018 Mar;35(3):367-381. doi: 10.1007/s12325-018-0668-2. Epub 2018 Feb 27.


[A Case of Surgery after Chemotherapy for Cecal Cancer with Onset of the Stenosis of the Colostomy].

Kono T, Yokomizo H, Yano Y, Okayama S, Satake M, Yamada Y, Ida A, Usui T, Yamaguchi K, Shiozawa S, Yoshimatsu K, Shimakawa T, Katsube T, Kato H, Naritaka Y.

Gan To Kagaku Ryoho. 2018 Feb;45(2):353-355. Japanese.


Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors.

Otsuka H, Kohashi K, Yoshimoto M, Ishihara S, Toda Y, Yamada Y, Yamamoto H, Nakashima Y, Oda Y.

Pathol Res Pract. 2018 Jan 31. pii: S0344-0338(17)31166-4. doi: 10.1016/j.prp.2017.12.015. [Epub ahead of print]


Institutional experience with SRS VMAT planning for multiple cranial metastases.

Ballangrud Å, Kuo LC, Happersett L, Lim SB, Beal K, Yamada Y, Hunt M, Mechalakos J.

J Appl Clin Med Phys. 2018 Mar;19(2):176-183. doi: 10.1002/acm2.12284. Epub 2018 Feb 23.


S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.

Yamada Y, Wakao S, Kushida Y, Minatoguchi S, Mikami A, Higashi K, Baba S, Shigemoto T, Kuroda Y, Kanamori H, Amin M, Kawasaki M, Nishigaki K, Taoka M, Isobe T, Muramatsu C, Dezawa M, Minatoguchi S.

Circ Res. 2018 Feb 23. pii: CIRCRESAHA.117.311648. doi: 10.1161/CIRCRESAHA.117.311648. [Epub ahead of print]


Absence of Rapid Propagation through the Purkinje Network as a Potential Cause of Line Block in the Human Heart with Left Bundle Branch Block.

Okada JI, Washio T, Nakagawa M, Watanabe M, Kadooka Y, Kariya T, Yamashita H, Yamada Y, Momomura SI, Nagai R, Hisada T, Sugiura S.

Front Physiol. 2018 Feb 6;9:56. doi: 10.3389/fphys.2018.00056. eCollection 2018.


Rituximab Induction to Prevent the Recurrence of PSC After Liver Transplantation-The Lessons Learned From ABO-Incompatible Living Donor Liver Transplantation.

Yamada Y, Hoshino K, Fuchimoto Y, Matsubara K, Hibi T, Yagi H, Abe Y, Shinoda M, Kitago M, Obara H, Yagi T, Okajima H, Kaido T, Uemoto S, Suzuki T, Kubota K, Yoshizumi T, Maehara Y, Inomata Y, Kitagawa Y, Egawa H, Kuroda T.

Transplant Direct. 2018 Feb 2;4(2):e342. doi: 10.1097/TXD.0000000000000760. eCollection 2018 Feb.


Prediction of Early BK Virus Infection in Kidney Transplant Recipients by the Number of Cells With Intranuclear Inclusion Bodies (Decoy Cells).

Yamada Y, Tsuchiya T, Inagaki I, Seishima M, Deguchi T.

Transplant Direct. 2018 Feb 2;4(2):e340. doi: 10.1097/TXD.0000000000000759. eCollection 2018 Feb.


Successful management of living donor liver transplantation for biliary atresia with single ventricle physiology-from peri-transplant through total cavopulmonary connection: A case report.

Yamada Y, Hoshino K, Oyanagi T, Gatayama R, Maeda J, Katori N, Fuchimoto Y, Hibi T, Shinoda M, Matsubara K, Obara H, Aeba R, Kitagawa Y, Yamagishi H, Kuroda T.

Pediatr Transplant. 2018 Feb 19. doi: 10.1111/petr.13118. [Epub ahead of print]


Discrimination of malignant transformation from benign endometriosis using a near-infrared approach.

Kawahara N, Yamada Y, Ito F, Hojo W, Iwabuchi T, Kobayashi H.

Exp Ther Med. 2018 Mar;15(3):3000-3005. doi: 10.3892/etm.2018.5779. Epub 2018 Jan 19.


Significance of Spread Through Air Spaces in Resected Pathological Stage I Lung Adenocarcinoma.

Toyokawa G, Yamada Y, Tagawa T, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Oda Y, Maehara Y.

Ann Thorac Surg. 2018 Feb 14. pii: S0003-4975(18)30155-3. doi: 10.1016/j.athoracsur.2018.01.037. [Epub ahead of print]


The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF).

Kotooka N, Kitakaze M, Nagashima K, Asaka M, Kinugasa Y, Nochioka K, Mizuno A, Nagatomo D, Mine D, Yamada Y, Kuratomi A, Okada N, Fujimatsu D, Kuwahata S, Toyoda S, Hirotani SI, Komori T, Eguchi K, Kario K, Inomata T, Sugi K, Yamamoto K, Tsutsui H, Masuyama T, Shimokawa H, Momomura SI, Seino Y, Sato Y, Inoue T, Node K; HOMES-HF study investigators.

Heart Vessels. 2018 Feb 15. doi: 10.1007/s00380-018-1133-5. [Epub ahead of print]


Continuous depth profile of the rock strength in the Nankai accretionary prism based on drilling performance parameters.

Hamada Y, Kitamura M, Yamada Y, Sanada Y, Sugihara T, Saito S, Moe K, Hirose T.

Sci Rep. 2018 Feb 14;8(1):2622. doi: 10.1038/s41598-018-20870-8.


P-gp modulating effect of Azadirachta indica extract in multidrug-resistant cancer cell lines.

Kawami M, Yamada Y, Issarachot O, Junyaprasert VB, Yumoto R, Takano M.

Pharmazie. 2018 Feb 1;73(2):104-109. doi: 10.1691/ph.2018.7116.


Effect of Curcuma comosa extracts on the functions of peptide transporter and P-glycoprotein in intestinal epithelial cells.

Kawami M, Yamada Y, Toshimori F, Issarachot O, Junyaprasert VB, Yumoto R, Takano M.

Pharmazie. 2017 Feb 1;72(2):123-127. doi: 10.1691/ph.2017.6147.


Identification of novel hyper- or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study.

Yamada Y, Horibe H, Oguri M, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Sawabe M.

Int J Mol Med. 2018 May;41(5):2724-2732. doi: 10.3892/ijmm.2018.3453. Epub 2018 Feb 2.


The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration.

Yamada Y, Ohazama A, Maeda T, Seo K.

Neurosci Lett. 2018 Feb 8;671:114-119. doi: 10.1016/j.neulet.2017.12.051. [Epub ahead of print]


Inhibition of integrin β1-mediated oncogenic signalling by the antitumor microRNA-29 family in head and neck squamous cell carcinoma.

Koshizuka K, Kikkawa N, Hanazawa T, Yamada Y, Okato A, Arai T, Katada K, Okamoto Y, Seki N.

Oncotarget. 2017 Dec 11;9(3):3663-3676. doi: 10.18632/oncotarget.23194. eCollection 2018 Jan 9.


Muscle glycogen depletion does not alter segmental extracellular and intracellular water distribution measured using bioimpedance spectroscopy.

Shiose K, Yamada Y, Motonaga K, Takahashi H.

J Appl Physiol (1985). 2018 Feb 8. doi: 10.1152/japplphysiol.00666.2017. [Epub ahead of print]


Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma.

Yamada Y, Arai T, Sugawara S, Okato A, Kato M, Kojima S, Yamazaki K, Naya Y, Ichikawa T, Seki N.

Cancer Sci. 2018 Feb 8. doi: 10.1111/cas.13526. [Epub ahead of print]


Validity of predictive equations for resting metabolic rate in healthy older adults.

Itoi A, Yamada Y, Yokoyama K, Adachi T, Kimura M.

Clin Nutr ESPEN. 2017 Dec;22:64-70. doi: 10.1016/j.clnesp.2017.08.010. Epub 2017 Sep 8.


Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease.

Ishikawa T, Somiya K, Munechika R, Harashima H, Yamada Y.

J Control Release. 2018 Mar 28;274:109-117. doi: 10.1016/j.jconrel.2018.02.005. Epub 2018 Feb 3.


Coping strategy and social support modify the association between perceived stress and C-reactive protein: a longitudinal study of healthy men and women.

Shimanoe C, Hara M, Nishida Y, Nanri H, Otsuka Y, Horita M, Yasukata J, Miyoshi N, Yamada Y, Higaki Y, Tanaka K.

Stress. 2018 Feb 5:1-10. doi: 10.1080/10253890.2018.1435638. [Epub ahead of print]


Cancer-testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non-uterine leiomyosarcoma.

Iura K, Kohashi K, Yasutake N, Ishii T, Maekawa A, Bekki H, Otsuka H, Yamada Y, Yamamoto H, Ohishi Y, Matsumoto Y, Iwamoto Y, Oda Y.

Oncol Lett. 2018 Jan;15(1):441-446. doi: 10.3892/ol.2017.7274. Epub 2017 Oct 26.


[A Case of Recurrence in the Posterior Wall of the Virginal after Radical Resection for Rectal Cancer Well Responded in a Long Period by Chemo-Radiotherapy].

Okayama S, Yoshimatsu K, Yokomizo H, Yano Y, Yamada Y, Satake M, Sakuma A, Matsumoto A, Fujimoto T, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Naritaka Y.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1197-1199. Japanese.


[Investigation of Cases with Curative Resection for Recurrent Colorectal Cancer].

Yokomizo H, Yano Y, Okayama S, Yamada Y, Satake M, Ida A, Usui T, Yamaguchi K, Shiozawa S, Yoshimatsu K, Shimakawa T, Katsube T, Kato H, Naritaka Y.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1194-1196. Japanese.


Evaluation of Drug Efficacy of GLP-1 Receptor Agonists and DPP-4 Inhibitors Based on Target Molecular Binding Occupancy.

Takayanagi R, Uchida T, Kimura K, Yamada Y.

Biol Pharm Bull. 2018;41(2):153-157. doi: 10.1248/bpb.b17-00237.


Improved overall survival over recent decades in patients with hormone-receptor-positive, HER2-negative breast cancer: a single-center retrospective analysis of prognostic factors.

Yamada Y, Mukai H, Tokudome Y, Kaneko M, Kashiwabara K, Wada N.

Jpn J Clin Oncol. 2018 Mar 1;48(3):248-254. doi: 10.1093/jjco/hyy001.


Apparent diffusion coefficient value for a B-cell central nervous system lymphoma in a cat.

Tanaka T, Akiyoshi H, Shimazaki H, Kawakami R, Mie K, Yamada Y, Ohashi F.

JFMS Open Rep. 2018 Jan 23;4(1):2055116917750762. doi: 10.1177/2055116917750762. eCollection 2018 Jan-Jun.


Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy.

Sakamoto M, Matsumoto Y, Mori S, Ueda K, Inoue Y, Kurimoto T, Kanamori A, Yamada Y, Nakamura M.

PLoS One. 2018 Jan 26;13(1):e0191862. doi: 10.1371/journal.pone.0191862. eCollection 2018.

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