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Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.

Bime C, Pouladi N, Sammani S, Batai K, Casanova N, Zhou T, Kempf CL, Sun X, Camp SM, Wang T, Kittles RA, Lussier YA, Jones TK, Reilly JP, Meyer NJ, Christie JD, Karnes J, Gonzalez-Garay M, Christiani DC, Yates CR, Wurfel MM, Meduri GU, Garcia JGN.

Am J Respir Crit Care Med. 2018 Feb 9. doi: 10.1164/rccm.201705-0961OC. [Epub ahead of print]


Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome.

Esposito AJ, Bhatraju PK, Stapleton RD, Wurfel MM, Mikacenic C.

Crit Care. 2017 Dec 14;21(1):304. doi: 10.1186/s13054-017-1895-7.


Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

Gust J, Hay KA, Hanafi LA, Li D, Myerson D, Gonzalez-Cuyar LF, Yeung C, Liles WC, Wurfel M, Lopez JA, Chen J, Chung D, Harju-Baker S, Özpolat T, Fink KR, Riddell SR, Maloney DG, Turtle CJ.

Cancer Discov. 2017 Dec;7(12):1404-1419. doi: 10.1158/2159-8290.CD-17-0698. Epub 2017 Oct 12.


[Plastic surgery and informed consent - need to know].

Bichler C, Würfel M.

Handchir Mikrochir Plast Chir. 2017 Sep;49(4):247-250. doi: 10.1055/s-0043-116217. Epub 2017 Sep 28. German.


Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.

Hay KA, Hanafi LA, Li D, Gust J, Liles WC, Wurfel MM, López JA, Chen J, Chung D, Harju-Baker S, Cherian S, Chen X, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2017 Nov 23;130(21):2295-2306. doi: 10.1182/blood-2017-06-793141. Epub 2017 Sep 18.


Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.

Morrell ED, O'Mahony DS, Glavan BJ, Harju-Baker S, Nguyen C, Gunderson S, Abrahamson A, Radella F 2nd, Rona G, Black RA, Wurfel MM.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):117-125. doi: 10.1165/rcmb.2017-0030OC.


Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype.

Bhatraju PK, Robinson-Cohen C, Mikacenic C, Harju-Baker S, Dmyterko V, Slivinski NSJ, Liles WC, Himmelfarb J, Heckbert SR, Wurfel MM.

Crit Care. 2017 Aug 17;21(1):217. doi: 10.1186/s13054-017-1807-x.


Th17 cells are associated with protection from ventilator associated pneumonia.

Orlov M, Dmyterko V, Wurfel MM, Mikacenic C.

PLoS One. 2017 Aug 14;12(8):e0182966. doi: 10.1371/journal.pone.0182966. eCollection 2017.


Peripheral and Alveolar Cell Transcriptional Programs Are Distinct in Acute Respiratory Distress Syndrome.

Morrell ED, Radella F 2nd, Manicone AM, Mikacenic C, Stapleton RD, Gharib SA, Wurfel MM.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):528-532. doi: 10.1164/rccm.201703-0614LE. No abstract available.


A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.

Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1004-1011. doi: 10.1164/rccm.201611-2307OC.


Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM.

Crit Care. 2016 Nov 17;20(1):372.


Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments.

Gittelman RM, Schraiber JG, Vernot B, Mikacenic C, Wurfel MM, Akey JM.

Curr Biol. 2016 Dec 19;26(24):3375-3382. doi: 10.1016/j.cub.2016.10.041. Epub 2016 Nov 10.


Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study.

Seaton ME, Parent BA, Sood RF, Wurfel MM, Muffley LA, O'Keefe GE, Gibran NS.

Shock. 2017 Jan;47(1):79-85.


Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients.

Robinson-Cohen C, Katz R, Price BL, Harju-Baker S, Mikacenic C, Himmelfarb J, Liles WC, Wurfel MM.

Crit Care. 2016 Jul 3;20(1):207. doi: 10.1186/s13054-016-1385-3.


COPD disease severity and innate immune response to pathogen-associated molecular patterns.

Fan VS, Gharib SA, Martin TR, Wurfel MM.

Int J Chron Obstruct Pulmon Dis. 2016 Mar 4;11:467-77. doi: 10.2147/COPD.S94410. eCollection 2016.


Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology.

Hahn WO, Mikacenic C, Price BL, Harju-Baker S, Katz R, Himmelfarb J, Wurfel MM, Liles WC.

Virulence. 2016 May 18;7(4):387-94. doi: 10.1080/21505594.2016.1144003. Epub 2016 Jan 28. No abstract available.


A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria.

Hahn WO, Harju-Baker S, Erdman LK, Krudsood S, Kain KC, Wurfel MM, Liles WC.

Malar J. 2016 Jan 6;15:12. doi: 10.1186/s12936-015-1071-y.


Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome.

Mikacenic C, Hansen EE, Radella F, Gharib SA, Stapleton RD, Wurfel MM.

Crit Care Med. 2016 Mar;44(3):496-502. doi: 10.1097/CCM.0000000000001409.


Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness.

Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM.

PLoS One. 2015 Oct 22;10(10):e0141251. doi: 10.1371/journal.pone.0141251. eCollection 2015.


Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

Bhatraju P, Hsu C, Mukherjee P, Glavan BJ, Burt A, Mikacenic C, Himmelfarb J, Wurfel M.

Crit Care. 2015 Oct 19;19:368. doi: 10.1186/s13054-015-1084-5.


TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.

Thair SA, Topchiy E, Boyd JH, Cirstea M, Wang C, Nakada TA, Fjell CD, Wurfel M, Russell JA, Walley KR.

J Innate Immun. 2016;8(1):57-66. doi: 10.1159/000437330. Epub 2015 Sep 9.


Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.

Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM.

J Immunol. 2014 Dec 15;193(12):5786-90. doi: 10.4049/jimmunol.1401185. Epub 2014 Nov 5.


Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.

Wei Y, Wang Z, Su L, Chen F, Tejera P, Bajwa EK, Wurfel MM, Lin X, Christiani DC.

Chest. 2015 Mar;147(3):607-617. doi: 10.1378/chest.14-1246.


IL1RN single-nucleotide polymorphisms in septic shock: can genetics clear the fog of the cytokine storm?

Wurfel MM, Mikacenic C.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):599-600. doi: 10.1164/rccm.201408-1506ED. No abstract available.


APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

Gale SC, Gao L, Mikacenic C, Coyle SM, Rafaels N, Murray Dudenkov T, Madenspacher JH, Draper DW, Ge W, Aloor JJ, Azzam KM, Lai L, Blackshear PJ, Calvano SE, Barnes KC, Lowry SF, Corbett S, Wurfel MM, Fessler MB.

J Allergy Clin Immunol. 2014 Jul;134(1):127-34. doi: 10.1016/j.jaci.2014.01.032. Epub 2014 Mar 18.


Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):262-72. doi: 10.1165/rcmb.2013-0238OC.


On-time clinical phenotype prediction based on narrative reports.

Bejan CA, Vanderwende L, Evans HL, Wurfel MM, Yetisgen-Yildiz M.

AMIA Annu Symp Proc. 2013 Nov 16;2013:103-10. eCollection 2013.


A variational Bayes discrete mixture test for rare variant association.

Logsdon BA, Dai JY, Auer PL, Johnsen JM, Ganesh SK, Smith NL, Wilson JG, Tracy RP, Lange LA, Jiao S, Rich SS, Lettre G, Carlson CS, Jackson RD, O'Donnell CJ, Wurfel MM, Nickerson DA, Tang H, Reiner AP, Kooperberg C; NHLBI GO Exome Sequencing Project.

Genet Epidemiol. 2014 Jan;38(1):21-30.


Automated tools for phenotype extraction from medical records.

Yetisgen-Yildiz M, Bejan CA, Vanderwende L, Xia F, Evans HL, Wurfel MM.

AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:283. eCollection 2013.


Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.

Chantratita N, Tandhavanant S, Myers ND, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle LE, Ernst RK, Emond MJ, Wurfel MM, Day NP, Peacock SJ, West TE.

PLoS One. 2013 Nov 26;8(11):e81617. doi: 10.1371/journal.pone.0081617. eCollection 2013.


Genetic variants associated with susceptibility to Helicobacter pylori.

Wurfel MM, Hawn TR.

JAMA. 2013 Sep 4;310(9):976. doi: 10.1001/jama.2013.194762. No abstract available.


Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study.

Thompson CM, Holden TD, Rona G, Laxmanan B, Black RA, OʼKeefe GE, Wurfel MM.

Ann Surg. 2014 Jan;259(1):179-85. doi: 10.1097/SLA.0b013e31828538e8.


IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.

Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O'Keefe GE, Wurfel MM, Christiani DC, Christie JD.

Am J Respir Crit Care Med. 2013 May 1;187(9):950-9. doi: 10.1164/rccm.201208-1501OC.


Impaired TLR5 functionality is associated with survival in melioidosis.

West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ.

J Immunol. 2013 Apr 1;190(7):3373-9. doi: 10.4049/jimmunol.1202974. Epub 2013 Feb 27.


Assessing pneumonia identification from time-ordered narrative reports.

Bejan CA, Vanderwende L, Wurfel MM, Yetisgen-Yildiz M.

AMIA Annu Symp Proc. 2012;2012:1119-28. Epub 2012 Nov 3.


Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study.

O'Mahony DS, Glavan BJ, Holden TD, Fong C, Black RA, Rona G, Tejera P, Christiani DC, Wurfel MM.

PLoS One. 2012;7(12):e51104. doi: 10.1371/journal.pone.0051104. Epub 2012 Dec 14.


Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.

Mikacenic C, Reiner AP, Holden TD, Nickerson DA, Wurfel MM.

Genes Immun. 2013 Jan;14(1):52-7. doi: 10.1038/gene.2012.53. Epub 2012 Nov 15.


Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin.

Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC.

J Med Genet. 2012 Nov;49(11):671-80. doi: 10.1136/jmedgenet-2012-100972. Epub 2012 Oct 9.


Kinetics of IgM and IgA antibody response to 23-valent pneumococcal polysaccharide vaccination in healthy subjects.

Schütz K, Hughes RG, Parker A, Quinti I, Thon V, Cavaliere M, Würfel M, Herzog W, Gessner JE, Baumann U.

J Clin Immunol. 2013 Jan;33(1):288-96. doi: 10.1007/s10875-012-9792-y. Epub 2012 Sep 25.


Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA; NHLBI GO Exome Sequencing Project—ESP Lung Project Team, Christiani DC, Wurfel MM, Lin X.

Am J Hum Genet. 2012 Aug 10;91(2):224-37. doi: 10.1016/j.ajhg.2012.06.007. Epub 2012 Aug 2.


Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.

Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi: 10.1073/pnas.1206701109. Epub 2012 Jul 25.


Pneumonia identification using statistical feature selection.

Bejan CA, Xia F, Vanderwende L, Wurfel MM, Yetisgen-Yildiz M.

J Am Med Inform Assoc. 2012 Sep-Oct;19(5):817-23. doi: 10.1136/amiajnl-2011-000752. Epub 2012 Apr 26.


Ventilator-associated pneumonia: bacteremia and death after traumatic injury.

O'Keefe GE, Caldwell E, Cuschieri J, Wurfel MM, Evans HL.

J Trauma Acute Care Surg. 2012 Mar;72(3):713-9. doi: 10.1097/TA.0b013e3182349d14.


Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H; Trauma ALI SNP Consortium (TASC) investigators.

PLoS One. 2012;7(1):e28268. doi: 10.1371/journal.pone.0028268. Epub 2012 Jan 25.


A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands.

Sutherland AM, Walley KR, Nakada TA, Sham AH, Wurfel MM, Russell JA.

J Innate Immun. 2011;3(5):447-58. doi: 10.1159/000323880. Epub 2011 May 14.


A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.

Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB, Akhtar SR, Ruzinski JT, Caldwell E, Curtis JR, Heyland DK, Watkins TR, Parsons PE, Martin JM, Wurfel MM, Hallstrand TS, Sims KA, Neff MJ.

Crit Care Med. 2011 Jul;39(7):1655-62. doi: 10.1097/CCM.0b013e318218669d.


ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD.

Am J Respir Crit Care Med. 2011 May 15;183(10):1344-53. doi: 10.1164/rccm.201005-0701OC. Epub 2011 Jan 21.


Identification and characterization of a loss-of-function human MPYS variant.

Jin L, Xu LG, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, Cambier JC.

Genes Immun. 2011 Jun;12(4):263-9. doi: 10.1038/gene.2010.75. Epub 2011 Jan 20.


MCP-1 gene activation marks acute kidney injury.

Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, Wurfel MM, Himmelfarb J, Zager RA.

J Am Soc Nephrol. 2011 Jan;22(1):165-75. doi: 10.1681/ASN.2010060641. Epub 2010 Nov 11.

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