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Items: 1 to 50 of 150

1.

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.

Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, van Galen P, Bonal DM, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popović M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein BE, Suvà ML.

Science. 2018 Apr 20;360(6386):331-335. doi: 10.1126/science.aao4750.

PMID:
29674595
2.

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.

Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr., Harvey CJ, Kobold S, Pyrdol JW, Yoon C, Yuan GC, Hodi FS, Dranoff G, Wucherpfennig KW.

Science. 2018 Mar 30;359(6383):1537-1542. doi: 10.1126/science.aao0505.

PMID:
29599246
3.

A facile approach to enhance antigen response for personalized cancer vaccination.

Li AW, Sobral MC, Badrinath S, Choi Y, Graveline A, Stafford AG, Weaver JC, Dellacherie MO, Shih TY, Ali OA, Kim J, Wucherpfennig KW, Mooney DJ.

Nat Mater. 2018 Mar 5. doi: 10.1038/s41563-018-0028-2. [Epub ahead of print]

PMID:
29507416
4.

Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses.

Choi IK, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, Liu Y, Kim HJ, Ritz J, Cantor H, Rajewsky K, Wucherpfennig KW, Zhang B.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E686-E695. doi: 10.1073/pnas.1713607115. Epub 2018 Jan 8.

PMID:
29311309
5.

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.

Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan GC, Doench J, Brown M, Liu XS, Wucherpfennig KW.

Science. 2018 Feb 16;359(6377):770-775. doi: 10.1126/science.aao1710. Epub 2018 Jan 4.

PMID:
29301958
6.

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.

Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS.

Nat Commun. 2017 Nov 23;8(1):1747. doi: 10.1038/s41467-017-01830-8.

7.

Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.

Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173d. No abstract available.

PMID:
28926530
8.

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.

Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW.

Nat Immunol. 2017 Jul;18(7):791-799. doi: 10.1038/ni.3755. Epub 2017 May 22. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.

9.

Immunomodulation for glioblastoma.

Reardon DA, Wen PY, Wucherpfennig KW, Sampson JH.

Curr Opin Neurol. 2017 Jun;30(3):361-369. doi: 10.1097/WCO.0000000000000451. Review.

PMID:
28368867
10.

Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET.

Gagnon E, Connolly A, Dobbins J, Wucherpfennig KW.

Methods Mol Biol. 2017;1584:259-289. doi: 10.1007/978-1-4939-6881-7_16.

PMID:
28255707
11.

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL.

J Nucl Med. 2017 Jun;58(6):1003-1008. doi: 10.2967/jnumed.116.186007. Epub 2017 Feb 16.

12.

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation.

Verbeke CS, Gordo S, Schubert DA, Lewin SA, Desai RM, Dobbins J, Wucherpfennig KW, Mooney DJ.

Adv Healthc Mater. 2017 Mar;6(6). doi: 10.1002/adhm.201600773. Epub 2017 Jan 24.

13.

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors.

Awad MM, Jones RE, Liu H, Lizotte PH, Ivanova EV, Kulkarni M, Herter-Sprie GS, Liao X, Santos AA, Bittinger MA, Keogh L, Koyama S, Almonte C, English JM, Barlow J, Richards WG, Barbie DA, Bass AJ, Rodig SJ, Hodi FS, Wucherpfennig KW, Jänne PA, Sholl LM, Hammerman PS, Wong KK, Bueno R.

Cancer Immunol Res. 2016 Dec;4(12):1038-1048. Epub 2016 Nov 14.

14.

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.

Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW.

Sci Signal. 2016 Jul 26;9(438):ra75. doi: 10.1126/scisignal.aaf0626.

PMID:
27460989
15.

Genetic screens to study the immune system in cancer.

Wucherpfennig KW, Cartwright AN.

Curr Opin Immunol. 2016 Aug;41:55-61. doi: 10.1016/j.coi.2016.05.007. Epub 2016 Jun 13. Review.

16.

Clinical and MRI phenotype of children with MOG antibodies.

Fernandez-Carbonell C, Vargas-Lowy D, Musallam A, Healy B, McLaughlin K, Wucherpfennig KW, Chitnis T.

Mult Scler. 2016 Feb;22(2):174-84. doi: 10.1177/1352458515587751. Epub 2015 Jun 3.

17.

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.

Sollid LM, Pos W, Wucherpfennig KW.

Curr Opin Immunol. 2014 Dec;31:24-30. doi: 10.1016/j.coi.2014.08.005. Epub 2014 Sep 15. Review.

18.

Immunotherapy advances for glioblastoma.

Reardon DA, Freeman G, Wu C, Chiocca EA, Wucherpfennig KW, Wen PY, Fritsch EF, Curry WT Jr, Sampson JH, Dranoff G.

Neuro Oncol. 2014 Nov;16(11):1441-58. doi: 10.1093/neuonc/nou212. Epub 2014 Sep 4. Review.

19.

Discovering cancer immunotherapy targets in vivo.

Zhou P, Wucherpfennig KW.

Oncoimmunology. 2014 Apr 17;3:e28500. eCollection 2014.

20.

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.

Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA.

J Immunol. 2014 Jul 1;193(1):258-67. doi: 10.4049/jimmunol.1400322. Epub 2014 Jun 4.

21.

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals.

Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, Tsang JS, Li Y, Fauci AS.

J Clin Invest. 2014 Jul;124(7):3252-62. doi: 10.1172/JCI74351. Epub 2014 Jun 2.

22.

Deconstructing the peptide-MHC specificity of T cell recognition.

Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC.

Cell. 2014 May 22;157(5):1073-87. doi: 10.1016/j.cell.2014.03.047.

23.

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ.

Cancer Immunol Res. 2014 Jul;2(7):655-67. doi: 10.1158/2326-6066.CIR-13-0209. Epub 2014 Mar 31.

24.

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML.

Nature. 2014 Mar 6;507(7490):118-23. doi: 10.1038/nature12951. Epub 2014 Feb 2.

25.

In vivo discovery of immunotherapy targets in the tumour microenvironment.

Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.

Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29.

26.

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.

Sethi DK, Gordo S, Schubert DA, Wucherpfennig KW.

Nat Commun. 2013;4:2623. doi: 10.1038/ncomms3623.

27.

Cracking the code of human T-cell immunity.

Harvey CJ, Wucherpfennig KW.

Nat Biotechnol. 2013 Jul;31(7):609-10. doi: 10.1038/nbt.2626. No abstract available.

PMID:
23839145
28.

Mechanisms of peptide repertoire selection by HLA-DM.

Pos W, Sethi DK, Wucherpfennig KW.

Trends Immunol. 2013 Oct;34(10):495-501. doi: 10.1016/j.it.2013.06.002. Epub 2013 Jul 5. Review.

29.

An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma.

Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT Jr, Mitchell DA, Fecci PE, Sampson JH, Dranoff G.

Expert Rev Vaccines. 2013 Jun;12(6):597-615. doi: 10.1586/erv.13.41. Review.

30.

Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

Pos W, Sethi DK, Call MJ, Schulze MS, Anders AK, Pyrdol J, Wucherpfennig KW.

Cell. 2012 Dec 21;151(7):1557-68. doi: 10.1016/j.cell.2012.11.025.

31.

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.

Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW.

J Exp Med. 2012 Dec 17;209(13):2423-39. doi: 10.1084/jem.20120790. Epub 2012 Nov 19.

32.

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells.

Torres AJ, Contento RL, Gordo S, Wucherpfennig KW, Love JC.

Lab Chip. 2013 Jan 7;13(1):90-9. doi: 10.1039/c2lc40869d. Epub 2012 Oct 15.

33.

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.

Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD.

RNA. 2012 Nov;18(11):2041-55. doi: 10.1261/rna.035675.112. Epub 2012 Sep 27. Erratum in: RNA. 2012 Dec;18(12):2345.

34.

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.

Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9.

35.

Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.

Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM.

AIDS. 2012 Oct 23;26(16):2112-5. doi: 10.1097/QAD.0b013e328358cc75.

36.

Self-reactive human CD4 T cell clones form unusual immunological synapses.

Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW.

J Exp Med. 2012 Feb 13;209(2):335-52. doi: 10.1084/jem.20111485. Epub 2012 Feb 6.

37.

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway.

Schulze MS, Wucherpfennig KW.

Curr Opin Immunol. 2012 Feb;24(1):105-11. doi: 10.1016/j.coi.2011.11.004. Epub 2011 Dec 2. Review.

38.

Autoimmune diseases have been the focus of intense research efforts.

Wucherpfennig KW, Noelle RJ.

Curr Opin Immunol. 2011 Dec;23(6):699-701. doi: 10.1016/j.coi.2011.10.003. Epub 2011 Nov 3. No abstract available.

PMID:
22056155
39.

Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display.

Wen F, Sethi DK, Wucherpfennig KW, Zhao H.

Protein Eng Des Sel. 2011 Sep;24(9):701-9. doi: 10.1093/protein/gzr035. Epub 2011 Jul 13.

40.

MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells.

Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD.

PLoS One. 2011 Mar 8;6(3):e16956. doi: 10.1371/journal.pone.0016956.

41.

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.

Wucherpfennig KW, Sethi D.

Semin Immunol. 2011 Apr;23(2):84-91. doi: 10.1016/j.smim.2011.01.007. Review.

42.

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.

Sethi DK, Schubert DA, Anders AK, Heroux A, Bonsor DA, Thomas CP, Sundberg EJ, Pyrdol J, Wucherpfennig KW.

J Exp Med. 2011 Jan 17;208(1):91-102. doi: 10.1084/jem.20100725. Epub 2011 Jan 3.

43.

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.

Anders AK, Call MJ, Schulze MS, Fowler KD, Schubert DA, Seth NP, Sundberg EJ, Wucherpfennig KW.

Nat Immunol. 2011 Jan;12(1):54-61. doi: 10.1038/ni.1967. Epub 2010 Dec 5.

44.

The first structures of T cell receptors bound to peptide-MHC.

Wucherpfennig KW.

J Immunol. 2010 Dec 1;185(11):6391-3. doi: 10.4049/jimmunol.1090110. No abstract available.

45.

The structural basis for intramembrane assembly of an activating immunoreceptor complex.

Call ME, Wucherpfennig KW, Chou JJ.

Nat Immunol. 2010 Nov;11(11):1023-9. doi: 10.1038/ni.1943. Epub 2010 Oct 3.

46.

Response multilayered control of T cell receptor phosphorylation.

Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW.

Cell. 2010 Sep 3;142(5):669-71. doi: 10.1016/j.cell.2010.08.019. No abstract available.

47.

Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.

Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME.

Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a005140. doi: 10.1101/cshperspect.a005140. Epub 2010 Mar 17. Review.

48.

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.

Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK.

J Clin Invest. 2010 Apr;120(4):1324-36. doi: 10.1172/JCI40220.

49.

Positively selecting peptides: their job does not end in the thymus.

Wucherpfennig KW, Gagnon E.

Nat Immunol. 2009 Nov;10(11):1143-4. doi: 10.1038/ni1109-1143.

PMID:
19841646
50.

Structural alterations in peptide-MHC recognition by self-reactive T cell receptors.

Wucherpfennig KW, Call MJ, Deng L, Mariuzza R.

Curr Opin Immunol. 2009 Dec;21(6):590-5. doi: 10.1016/j.coi.2009.07.008. Epub 2009 Aug 19. Review.

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