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The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population.

Kay C, Collins JA, Wright GEB, Baine F, Miedzybrodzka Z, Aminkeng F, Semaka AJ, McDonald C, Davidson M, Madore SJ, Gordon ES, Gerry NP, Cornejo-Olivas M, Squitieri F, Tishkoff S, Greenberg JL, Krause A, Hayden MR.

Am J Med Genet B Neuropsychiatr Genet. 2018 Apr;177(3):346-357. doi: 10.1002/ajmg.b.32618. Epub 2018 Feb 20.


Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients.

Drögemöller BI, Brooks B, Critchley C, Monzon JG, Wright GEB, Liu G, Renouf DJ, Kollmannsberger CK, Bedard PL, Hayden MR, Gelmon KA, Carleton BC, Ross CJD.

Clin Cancer Res. 2018 Jan 22. doi: 10.1158/1078-0432.CCR-17-2810. [Epub ahead of print]


Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

McCormack M, Gui H, Ingason A, Speed D, Wright GEB, Zhang EJ, Secolin R, Yasuda C, Kwok M, Wolking S, Becker F, Rau S, Avbersek A, Heggeli K, Leu C, Depondt C, Sills GJ, Marson AG, Auce P, Brodie MJ, Francis B, Johnson MR, Koeleman BPC, Striano P, Coppola A, Zara F, Kunz WS, Sander JW, Lerche H, Klein KM, Weckhuysen S, Krenn M, Gudmundsson LJ, Stefánsson K, Krause R, Shear N, Ross CJD, Delanty N; EPIGEN Consortium;, Pirmohamed M, Carleton BC; Canadian Pharmacogenomics Network for Drug Safety;, Cendes F, Lopes-Cendes I, Liao WP, O'Brien TJ, Sisodiya SM; EpiPGX Consortium;, Cherny S, Kwan P, Baum L; International League Against Epilepsy Consortium on Complex Epilepsies;, Cavalleri GL.

Neurology. 2018 Jan 23;90(4):e332-e341. doi: 10.1212/WNL.0000000000004853. Epub 2017 Dec 29.


Interstage evaluation of homograft-valved right ventricle to pulmonary artery conduits for palliation of hypoplastic left heart syndrome.

Sandeep N, Punn R, Balasubramanian S, Smith SN, Reinhartz O, Zhang Y, Wright GE, Peng LF, Wise-Faberowski L, Hanley FL, McElhinney DB.

J Thorac Cardiovasc Surg. 2017 Nov 8. pii: S0022-5223(17)32427-3. doi: 10.1016/j.jtcvs.2017.11.001. [Epub ahead of print]


Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

Drögemöller BI, Monzon JG, Bhavsar AP, Borrie AE, Brooks B, Wright GEB, Liu G, Renouf DJ, Kollmannsberger CK, Bedard PL, Aminkeng F, Amstutz U, Hildebrand CA, Gunaretnam EP, Critchley C, Chen Z, Brunham LR, Hayden MR, Ross CJD, Gelmon KA, Carleton BC.

JAMA Oncol. 2017 Nov 1;3(11):1558-1562. doi: 10.1001/jamaoncol.2017.0502.


The global spectrum of protein-coding pharmacogenomic diversity.

Wright GEB, Carleton B, Hayden MR, Ross CJD.

Pharmacogenomics J. 2018 Jan;18(1):187-195. doi: 10.1038/tpj.2016.77. Epub 2016 Oct 25.


The identification of novel genetic variants associated with antipsychotic treatment response outcomes in first-episode schizophrenia patients.

Drögemöller BI, Emsley R, Chiliza B, van der Merwe L, Wright GE, Daya M, Hoal E, Malhotra AK, Lencz T, Robinson DG, Zhang JP, Asmal L, Niehaus DJ, Warnich L.

Pharmacogenet Genomics. 2016 May;26(5):235-42. doi: 10.1097/FPC.0000000000000213.


Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ.

Vasuvat J, Montree A, Moonsom S, Leartsakulpanich U, Petmitr S, Focher F, Wright GE, Chavalitshewinkoon-Petmitr P.

Malar J. 2016 Feb 24;15:116. doi: 10.1186/s12936-016-1166-0.


Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):501-9. doi: 10.1161/ATVBAHA.115.306885. Epub 2016 Jan 7.


CYP2B6*6 and CYP2B6*18 Predict Long-Term Efavirenz Exposure Measured in Hair Samples in HIV-Positive South African Women.

Röhrich CR, Drögemöller BI, Ikediobi O, van der Merwe L, Grobbelaar N, Wright GE, McGregor N, Warnich L.

AIDS Res Hum Retroviruses. 2016 Jun;32(6):529-38. doi: 10.1089/AID.2015.0048. Epub 2016 Jan 29.


Mitral Stenosis and Aortic Atresia--A Risk Factor for Mortality After the Modified Norwood Operation in Hypoplastic Left Heart Syndrome.

Siehr SL, Maeda K, Connolly AA, Tacy TA, Reddy VM, Hanley FL, Perry SB, Wright GE.

Ann Thorac Surg. 2016 Jan;101(1):162-7. doi: 10.1016/j.athoracsur.2015.09.056. Epub 2015 Nov 18.


New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors.

Yanachkov IB, Chang H, Yanachkova MI, Dix EJ, Berny-Lang MA, Gremmel T, Michelson AD, Wright GE, Frelinger AL 3rd.

Eur J Med Chem. 2016 Jan 1;107:204-18. doi: 10.1016/j.ejmech.2015.10.055. Epub 2015 Nov 9.


Prodrugs of herpes simplex thymidine kinase inhibitors.

Yanachkova M, Xu WC, Dvoskin S, Dix EJ, Yanachkov IB, Focher F, Savi L, Sanchez MD, Foster TP, Wright GE.

Antivir Chem Chemother. 2015 Apr;24(2):47-55. doi: 10.1177/2040206615608722. Epub 2015 Oct 13.


A liposomal method for evaluation of inhibitors of H(+)-coupled multidrug transporters.

Melchior DL, Brill S, Wright GE, Schuldiner S.

J Pharmacol Toxicol Methods. 2016 Jan-Feb;77:53-7. doi: 10.1016/j.vascn.2015.09.007. Epub 2015 Oct 20.


Genomic study of congenital insensitivity to pain provides new avenues for the development of analgesics.

Wright GE.

Clin Genet. 2015 Oct;88(4):342-3. doi: 10.1111/cge.12652. No abstract available.


Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort.

Dodgen TM, Drögemöller BI, Wright GE, Warnich L, Steffens FE, Cromarty AD, Alessandrini M, Pepper MS.

Pharmacogenomics. 2015;16(12):1343-54. doi: 10.2217/pgs.15.80. Epub 2015 Aug 5.


Warfarin pharmacogenetics in the era of new oral anticoagulants.

Wright GE.

Clin Genet. 2015 Aug;88(2):135-6. doi: 10.1111/cge.12609. Epub 2015 Jun 4. No abstract available.


Informed consent and ethical re-use of African genomic data.

Wright GE, Adeyemo AA, Tiffin N.

Hum Genomics. 2014 Oct 22;8:18. doi: 10.1186/s40246-014-0018-7.


Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target.

Suksangpleng T, Leartsakulpanich U, Moonsom S, Siribal S, Boonyuen U, Wright GE, Chavalitshewinkoon-Petmitr P.

Malar J. 2014 Apr 17;13:149. doi: 10.1186/1475-2875-13-149.


Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.

Chang H, Yanachkov IB, Dix EJ, Yanachkova M, Li Y, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd.

PLoS One. 2014 Apr 10;9(4):e94780. doi: 10.1371/journal.pone.0094780. eCollection 2014.


Considerations for rare variants in drug metabolism genes and the clinical implications.

Drögemöller BI, Wright GE, Warnich L.

Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):873-84. doi: 10.1517/17425255.2014.903239. Epub 2014 Mar 28. Review.


Patterns of variation influencing antipsychotic treatment outcomes in South African first-episode schizophrenia patients.

Drogemöller BI, Niehaus DJ, Chiliza B, van der Merwe L, Asmal L, Malhotra AK, Wright GE, Emsley R, Warnich L.

Pharmacogenomics. 2014 Feb;15(2):189-99. doi: 10.2217/pgs.13.218.


Next-generation sequencing of pharmacogenes: a critical analysis focusing on schizophrenia treatment.

Drögemöller BI, Wright GE, Niehaus DJ, Emsley R, Warnich L.

Pharmacogenet Genomics. 2013 Dec;23(12):666-74. doi: 10.1097/FPC.0000000000000006.


One hundred useful references in pediatric cardiac intensive care: the 2012 update.

Axelrod DM, Klugman D, Wright GE, Chang A, Bronicki R, Roth SJ; Board Members of the Pediatric Cardiac Intensive Care Society.

Pediatr Crit Care Med. 2013 Oct;14(8):770-85. doi: 10.1097/01.PCC.0000434621.25332.71.


Ethical and legal implications of whole genome and whole exome sequencing in African populations.

Wright GE, Koornhof PG, Adeyemo AA, Tiffin N.

BMC Med Ethics. 2013 May 28;14:21. doi: 10.1186/1472-6939-14-21.


Home monitoring program reduces interstage mortality after the modified Norwood procedure.

Siehr SL, Norris JK, Bushnell JA, Ramamoorthy C, Reddy VM, Hanley FL, Wright GE.

J Thorac Cardiovasc Surg. 2014 Feb;147(2):718-23.e1. doi: 10.1016/j.jtcvs.2013.04.006. Epub 2013 May 8.


Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study.

Dodgen TM, Hochfeld WE, Fickl H, Asfaha SM, Durandt C, Rheeder P, Drögemöller BI, Wright GE, Warnich L, Labuschagne CD, van Schalkwyk A, Gaedigk A, Pepper MS.

BMC Med Genet. 2013 Jan 29;14:20. doi: 10.1186/1471-2350-14-20.


Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation.

Chang H, Yanachkov IB, Dix EJ, Li YF, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd.

J Thromb Haemost. 2012 Dec;10(12):2573-80. doi: 10.1111/jth.12035.


Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE.

Barnes MH, Butler MM, Wright GE, Brown NC.

Infect Disord Drug Targets. 2012 Oct;12(5):327-31.


Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds.

Torti A, Lossani A, Savi L, Focher F, Wright GE, Brown NC, Xu WC.

Curr Enzym Inhib. 2011 Oct;7(3):147-153.


MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile.

Butler MM, Shinabarger DL, Citron DM, Kelly CP, Dvoskin S, Wright GE, Feng H, Tzipori S, Bowlin TL.

Antimicrob Agents Chemother. 2012 Sep;56(9):4786-92. doi: 10.1128/AAC.00508-12. Epub 2012 Jun 25.


Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.

Wright GE, Niehaus DJ, van der Merwe L, Koen L, Korkie LJ, Kinnear CJ, Drögemöller BI, Warnich L.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):163-9. doi: 10.1016/j.pnpbp.2012.06.006. Epub 2012 Jun 13.


Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation.

Warnich L, Drögemöller BI, Pepper MS, Dandara C, Wright GE.

Curr Pharmacogenomics Person Med. 2011 Sep;9(3):191-207.


End of the Beginning and Public Health Pharmacogenomics: Knowledge in 'Mode 2' and P5 Medicine.

Ozdemir V, Fisher E, Dove ES, Burton H, Wright GE, Masellis M, Warnich L.

Curr Pharmacogenomics Person Med. 2012 Jan 1;10(1):1-6. No abstract available.


Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers.

Melchior DL, Sharom FJ, Evers R, Wright GE, Chu JW, Wright SE, Chu X, Yabut J.

J Pharmacol Toxicol Methods. 2012 Mar;65(2):64-74. doi: 10.1016/j.vascn.2012.02.002. Epub 2012 Feb 26.


N2-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases.

Lossani A, Savi L, Manikowski A, Maioli A, Gambino J, Focher F, Spadari S, Wright GE.

J Mol Biochem. 2012;1(1):21-25.


A novel agent effective against Clostridium difficile infection.

Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE.

Antimicrob Agents Chemother. 2012 Mar;56(3):1624-6. doi: 10.1128/AAC.06097-11. Epub 2011 Dec 27.


Psychiatric genetics in South Africa: cutting a rough diamond.

Wright GE, Niehaus DJ, Koen L, Drögemöller BI, Warnich L.

Afr J Psychiatry (Johannesbg). 2011 Nov;14(5):355-66. doi: Review.


Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications.

Drögemöller BI, Wright GE, Niehaus DJ, Emsley RA, Warnich L.

Pharmacogenomics. 2011 Dec;12(12):1717-28. doi: 10.2217/pgs.11.119.


7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.

Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4197-202. doi: 10.1016/j.bmcl.2011.05.093. Epub 2011 May 30.


Implementation of a comprehensive interdisciplinary care coordination of infants and young children on Berlin Heart ventricular assist devices.

Staveski SL, Avery S, Rosenthal DN, Roth SJ, Wright GE.

J Cardiovasc Nurs. 2011 May-Jun;26(3):231-8. doi: 10.1097/JCN.0b013e3181f29a2e.


P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs.

Yanachkov IB, Dix EJ, Yanachkova MI, Wright GE.

Org Biomol Chem. 2011 Feb 7;9(3):730-8. doi: 10.1039/c0ob00542h. Epub 2010 Nov 17.


Characterization of the genetic profile of CYP2C19 in two South African populations.

Drögemöller BI, Wright GE, Niehaus DJ, Koen L, Malan S, Da Silva DM, Hillermann-Rebello R, La Grange AM, Venter M, Warnich L.

Pharmacogenomics. 2010 Aug;11(8):1095-103. doi: 10.2217/pgs.10.90.


Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population.

Wright GE, Niehaus DJ, Drögemöller BI, Koen L, Gaedigk A, Warnich L.

Ann Hum Genet. 2010 Jul;74(4):340-50. doi: 10.1111/j.1469-1809.2010.00585.x.


Effect of combinations of antiviral drugs on herpes simplex encephalitis.

Gebhardt BM, Focher F, Eberle R, Manikowski A, Wright GE.

Drug Des Devel Ther. 2009 Dec 29;3:289-94.


Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.

Chang H, Yanachkov IB, Michelson AD, Li Y, Barnard MR, Wright GE, Frelinger AL 3rd.

Thromb Res. 2010 Feb;125(2):159-65. doi: 10.1016/j.thromres.2009.11.006. Epub 2009 Nov 27.


Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

Lossani A, Torti A, Gatti S, Bruno A, Maserati R, Wright GE, Focher F.

Parasitology. 2009 May;136(6):595-602. doi: 10.1017/S0031182009005964. Epub 2009 Apr 16.


Access to cancer services for rural colorectal cancer patients.

Baldwin LM, Cai Y, Larson EH, Dobie SA, Wright GE, Goodman DC, Matthews B, Hart LG.

J Rural Health. 2008 Fall;24(4):390-9. doi: 10.1111/j.1748-0361.2008.00186.x.


A method to assay inhibitors of DNA polymerase IIIC activity.

Butler MM, Wright GE.

Methods Mol Med. 2008;142:25-36. doi: 10.1007/978-1-59745-246-5_3.


Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience.

Malaisrie SC, Pelletier MP, Yun JJ, Sharma K, Timek TA, Rosenthal DN, Wright GE, Robbins RC, Reitz BA.

J Heart Lung Transplant. 2008 Feb;27(2):173-7. doi: 10.1016/j.healun.2007.11.567.


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